<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29401

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTAELGQQTVELSTLVTRAANDSYASLKELVDKCKSSELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIHHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCIEDVGTQYALTEEQQKPALKKLDTLVRSKLLQVSIPKEFSNIMVSDGTAMLRLDGEFKVLITLGYRGHLSLWRILHLELLVGEKDKPVKLEATRRHLLGDDLERRMAAAENPFSVLYSVLHELCVALVMDTVIRQVQVLRQGRWKDAIRFELISEGHGASSSSALNPDGESDSSAMRTPGLKIVYWLDFDKNAGASESGTCPFLKIEPGSDLQIKCLHSSFVIDPLMGKEAEFVLDQSCIDVERLLLRAICCNKYTRLLEIKRELVKNVQVCRTADDVVLQSQMGELDIEYKQKDDKCCSKDSEGHEVLCVRAYGSSFFTLGINIRNGRFLLQSSQNIVVSSALLECEEALNQGSMTAAEVFISLRSKSLLHLFASIGRVLGLEVYEHEFNTVKIPKNVSNGSAMLLMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPNPSVKDNLSGELNQVLRIKEIDIGQMQVHEDEMNLSLVDWGKLRSVLPNAVCPNQTSGHEFFSDIRLENSIQIARGHPSGFSSLVDEVFGLEKGSSTPPFSVKNLSSSVNTSLPSQYGSVPMTLHSLKAGSPSPKWEVGMQMPLVSNVTKASSATNHYSGSLFSSGSVKGPVQSSSVGSIPTGQGRNSAGTKLSASKSEQDLASLKSLHSVDSSSSAAMDEEQLRVFSDNSNDALAGSRSSRLLSPPRPTGSRMSIPNSRPNGPQVESFKAAGSGSCATTPVSQTLESTVSYNTGEDVTSKNDRKSGKRTASDMLTLIPSLQGVESNSGICKKRKISDSAGCQLSLPQGVMSAEIIPRTEGYSYGSLIAEANKGNVPSSIYVAALLHVVRHCSLCIKHARLTSQMDALDISYVEEVGLRSGSSNIWFRLPLARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGINNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRKLLGVRAEEKSEELVTSSDTKTPSTKVALDTADKLTEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGGEVSPLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQNGSYISSHGLLLSNSTTNVGLPTSGPGANTVMPTASGLTSQTLSMLAASGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGMANSNNPNPGSGSQMMAANGNRINLPISAAMPRTGNQVASLNRVGNALAGSSNLALMTSAVSLRRPPGTVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQNSNPAPEELSQSEISEICDYFSRRVASEPYDASRVASFITMLTLPVAVLREFLKLIAWKKGLSQAQVGDVVSAQKPRIELCLENHSGLNMDENSESSSAFRSNIHYDRLHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESPNVSFIGMNGSHGGRACWLRVDDWEKCKQRVARTVEVNGNSAADVSQGRLKLIADSVQRNLHMCIQGLRDGSGVTTSSGAA
Length1814
PositionTail
OrganismGlycine max (Soybean) (Glycine hispida)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.06
Grand average of hydropathy-0.159
Instability index41.61
Isoelectric point7.52
Molecular weight197449.02
Publications
PubMed=20075913

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29401
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.26|      44|      46|     566|     611|       1
---------------------------------------------------------------------------
  566-  611 (66.54/55.81)	KLLETQPNPSVKDNLSG.ELNQVLRIkEIDIGQMQVHEDEMNlSLVD
  614-  658 (72.71/51.11)	KLRSVLPNAVCPNQTSGhEFFSDIRL.ENSIQIARGHPSGFS.SLVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.01|      40|      49|    1011|    1053|       2
---------------------------------------------------------------------------
 1011- 1053 (69.06/60.63)	HIclRLGRPGCM..YWDVKInDQHFRDLWELQKGINNTPWGSGVR
 1063- 1104 (60.96/41.16)	HI..HYDPDGVVlsYQSVEV.DSIKKLVADIQRLANARTFALGMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     440.14|     157|     354|       5|     194|       3
---------------------------------------------------------------------------
    5-  194 (217.48/250.43)	LGQQTVELSTLVTRA.ANDSYASLKELvdkckSSELSdtdKKISILKFLSKT..QQRMIRLNVLSKwcQQvplIHHCQQLAStvSNHD.MCFtQAADSLFF.....MHEG...LQQARAPVydVPSAI....DILLTGSYQRLPKCIedvgtqyaltEEQQKPALKKLDTLVRSKLLQV........SIPKEfsnimVSDGTAML...............RLDGEFKVL
  369-  564 (222.66/164.65)	LDQSCIDVERLLLRAiCCNKYTRLLEI.....KRELV...KNVQVCRTADDVvlQSQMGELDIEYK..QK...DDKCCSKDS..EGHEvLCV.RAYGSSFFtlginIRNGrflLQSSQNIV..VSSALleceEALNQGSMTAAEVFI..........SLRSKSLLHLFASIGRVLGLEVyehefntvKIPKN.....VSNGSAMLlmgfpdcgssyfllmQLDKDFKPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.45|      13|      20|    1401|    1420|       4
---------------------------------------------------------------------------
 1401- 1415 (20.45/24.05)	PGSGSQMmaANGNRI
 1424- 1436 (23.01/ 6.25)	PRTGNQV..ASLNRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.75|      22|      51|     846|     867|       5
---------------------------------------------------------------------------
  846-  867 (37.73/23.51)	SGSCATTPVSQTLESTVSYNTG
  900-  921 (39.02/24.59)	SGICKKRKISDSAGCQLSLPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.65|      41|     349|    1157|    1202|       6
---------------------------------------------------------------------------
 1157- 1202 (68.09/56.64)	LW.FSFGSGVLARFVVEWESGKEGCTMHVSPDQlwPHTKFledFING
 1508- 1549 (66.56/40.67)	LWlFAQLPELLKEILGSILKENEGALLNLDPEQ..PALRF...FVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.19|      45|     183|    1254|    1305|       7
---------------------------------------------------------------------------
  662-  706 (78.98/39.50)	GLEKGSSTPPFSVKNLSSSVNTSLPSQYGSVPMTLHSLKA.GSPSP
 1256- 1301 (73.21/45.98)	GLLLSNSTTNVGLPTSGPGANTVMPTASGLTSQTLSMLAAsGRGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.47|      14|      20|     771|     789|       8
---------------------------------------------------------------------------
  771-  789 (15.87/16.10)	EQDLASLKslhsvDSSSSA
  793-  806 (23.60/10.83)	EEQLRVFS.....DNSNDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.24|      13|      20|    1448|    1460|       9
---------------------------------------------------------------------------
 1448- 1460 (22.95/14.49)	LMTSAVSLRRPPG
 1471- 1483 (22.30/13.82)	LNTAIIGLGDDGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29401 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPVQSSSVGSIPTGQGRNSAGTKLSASKSEQDLASLKSLHSVDSSSSAAMDEEQLRVFSDNSNDALAGSRSSRLLSPPRPTGSRMSIPNSRPNGPQVESFKAAGSGSCA
2) VSQTLESTVSYNTGEDVTSKNDRKSGKRTASDMLTLI
742
854
850
890










Molecular Recognition Features






MoRF SequenceStartStop




NANANA