<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29294

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMASDDNNWRTQSFRQNVVSKIEEAIQRSGMQVARNSSEMETHVFLKAKNRDEYMNMVAKLILHVREMSQPKQNQGQPNMQVQNQNQSGPSTQVQPQQGQAPQGPNSQTGLAPDPINALQTLASQGSRNQMMNMGPQGQMQQQNVMQTQMGGMQSQLGQTGPIVSQGPQAQTATNLLQTLNQRPQMNMPMQNKLAGSMGMVGNQGQMGNNMGMGGMGNPMGSQLQNQLAGPSMQGQMMQNMSMSNNMAVPMSGANTMVGQMPCNQVGMGGQMPPNNMQGQMSGQMVGGMGNNQMVGMNMGHMQGRVQGKQEVGMLGAGYSRGPPPAQFLRQSPSPSAPSPGMPGPSPVSMGVMANTMPSPMSSLGGLAACGGSPSPSAPTHLAHHVSQQQRSVGMGMVQSPSPSLNTPQAALGAGSPGGEEAAYREKVRQLSKYIEPLRRMVHRMVSEGENVEKLKKMKNLLDILSNPNKRITLETLIKCEVVLEKLDFKRSEGVVVGLPGSGKEQIVNPLLEVVNNCLQSPLANHTLKRTFGSTLDALNGPEIKNVPPPYKAPKMAEPEMEIPDVLQGEIARLDSRFKATKKLFCGPTPGRVGDERAAGVRTQPGRVPAGPRARALSGIIASVR
Length624
PositionTail
OrganismBombyx mori (Silk moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Bombycoidea> Bombycidae> Bombycinae> Bombyx.
Aromaticity0.02
Grand average of hydropathy-0.564
Instability index57.55
Isoelectric point9.85
Molecular weight66725.93
Publications
PubMed=19121390

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29294
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     368.23|      46|      47|     223|     268|       1
---------------------------------------------------------------------------
   72-  111 (59.70/14.51)	.Q........NQ...GQPNMQVQ.NQNQ..S......GPSTQVQPQQG...QAP...QG.PN....................SQ.TGL.A
  118-  168 (52.91/12.01)	LQtlasqgsrNQMmnMGP..QGQMQQQ............NVMQTQMGGMQSQLG...QTgPI....................VS.QGP.Q
  169-  213 (55.42/12.93)	AQ.....tatNLL..QTLNQRPQM..NM..P......MQNKLAGSM.G...MVGnqgQM.G.....................NN.MGM.G
  223-  268 (93.68/27.05)	LQ........NQL..AGPSMQGQMMQNM..S......MSNNMAVPMSGANTMVG...QM.PC....................NQ.VGM.G
  271-  315 (57.78/13.80)	MP........PN......NMQGQMSGQMvgG......MGNNQMVGMNMGH.MQG...RV.QG....................KQeVGMlG
  327-  395 (48.73/10.47)	FL........RQS..PSPSAPSPGMPGP..SpvsmgvMANTMPSPMS...SLGG...LA.ACggspspsapthlahhvsqqqRS.VGM.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.14|      37|      44|     527|     563|       3
---------------------------------------------------------------------------
  500-  526 (29.87/10.56)	.....GSGKEQIVNPLLEVVNNCLQSP.LANHT....
  527-  563 (63.14/29.30)	LKRTFGSTLDALNGPEIKNVPPPYKAPKMAEPEMEIP
  573-  608 (59.13/27.05)	LDSRFKATKKLFCGPTPGRVGDERAAGVRTQP.GRVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.17|      29|      29|     425|     453|       4
---------------------------------------------------------------------------
  425-  453 (48.08/31.27)	EKVRQLSKYI.EPLRRMVHRMVSEGENV.EK
  455-  485 (37.09/22.68)	KKMKNLLDILsNPNKRITLETLIKCEVVlEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29294 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MASDDNNWRTQSFRQNVVSKIEEAIQRSGMQVARNSSEMETHVFLKAKN
2) NMVAKLILHVREMSQPKQNQGQPNMQVQNQNQSGPSTQVQPQQGQAPQGPNSQTGLAPDPINALQTLASQGSRNQMMNMGPQGQMQQQNVMQTQMGGMQSQLGQTGPIVSQGPQAQTATNLLQTLNQRPQMNMPMQNKLAGSMGMVGNQGQMGNNMGMGGMGNPMGSQLQNQLAGPSMQGQMMQNMSMSNNMAVPMSGANTMVGQMPCNQVGMGGQMPPNNMQGQMSGQMVGGMGNNQMVGMNMGHMQGRVQGKQEVGMLGAGYSRGPPPAQFLRQSPSPSAPSPGMPGPSPVSMGVMANTMPSPMSSLGGLAACGGSPSPSAPTHLAHHVSQQQRSVGMGMVQSPSPSLNTPQAALGAGSPGGEEAAYRE
1
55
49
425










Molecular Recognition Features






MoRF SequenceStartStop




NANANA