<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29292

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMTDGNLIMTANGLIDKSKELQKEILMEKLRSKTPQYKNLTETSKAVRTSMLDKRWGVDNADRMILQKCLDSLQHSIKITSLQNLIERLQCLSRQLGLKLVVGTSGVNLFISSDMFYLEILVESSGSVKDVKIHHEGKVKCKAFTALQSLEDDLCTLRQLQSFIKDPWAQVHKSPIGFLQKRRGGHAMRLTYFVSPYELLDKDAGLQPLTTELLTTGKPTASNGFASHGTPAYTPIGHSATVLLEGSTANKLQLSTIISNAQRSGKSNGPVYAPLVPQNSAMLPACFTLKLSQPTPLCSGLAKLIQATTEVEVSGDWANAKPLLGLVVQQAYDKLVPGKNIELNLSKGLFVNLPKQTQCYFVCERRGLEGCIVNSVPFTHPSHVAALLACLRQQALFNTLLASCVRLQTKLAVELEKVLMFEVSALSWQHISISLEHPLEECMATVELELSDPASPRASVYTLNSPARDHIDDYITRVLQKSHSIPITLRSLVKIWEREAAAKQMNGGYSALDSNFSCGVGGLDPGGEQLKHEPAHPHRALYPHPHHAGAYLSEQQHQLTMMCQDSNESKHQEERKSKKRKSDSDVWSTAQKKGKPGLSDMMDSDSESDNSDNYANEDDNTVNSNSSTEDLEGRESSASQNEFTSDLELSTMDAADALRNQDNRTSSDIDNSNDGDVEEIMRNSFQKSDHKRQKLKSKDSEMRRSSSSLLLDLTEGKSYMPSSVSITPIGSSSANPQPPSGAGISSMLCLDRRPGIEIIPISAAAPAALPSSITITPITSSQIKSMDDRIRSDRKSSKSGEERSKEKKKKRRRDDSMGPPEKVPPKQDPLTKPVSVSIKPTDGSPLRASSPNSLIRKFSPSPTHGRSVSITKSPSPSTVKGIGKPSGTSSHHSSPRHSPVQNSPKHLTGYSSPKNHSISSPKQSSSGSGKPSMSALKSATSGSPSAKSGTTGYDLTKKISKDNYSSSSSTSRDKEKKHSSLSFSSSDRSSPKLKNPMKIKQLEITPVTCDSAVTEPLISPPNIEVNKPNASQARNRKGSLSAVIDKLKSAQHCGGDSDSSSKSSGSSSSVGKFSEQKNSLPASGGKTSESKNQEYMVKPSSDGMKITINKTRSKESSSSSKLNYSSSKQSSPQLTPPSQGSPKTHTGLKPGVISGPASKKTQAMQSSKSSSLNTSSTPPKANMSPSDSSNPNMSKVPYSKSSSSSSSAGINLSKSASKSNSGSPKGSSSDLAKIIRDREREKARTKLMSNSEKSIFSSKSERHSSPSGSRDDVDGDRIKSSKDVNFRVEGLMKPLDTRNFQIPKLKDKNSPAAQYENRSMVNDFSRSLDQNKYPFSHYDNSNKGSESMQKSAYPLNVPKPLMNLGAMSPKTTGKSDQSDRPMEYSKATADSLTKGGSPQRNKDEAKDAYSSSYPLMPLDFKTDMAKGFATPKGAPEDRKGADSCMKPPASASVARSGATTPQEAAEMLLDFSSSSGSKVSGLVAVRPVYPASPALALQLAKSPAPSPLVAPSPHSNSPCITDDELIDEGLVGPGK
Length1534
PositionMiddle
OrganismBombyx mori (Silk moth)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Bombycoidea> Bombycidae> Bombycinae> Bombyx.
Aromaticity0.04
Grand average of hydropathy-0.682
Instability index60.74
Isoelectric point9.34
Molecular weight165354.98
Publications
PubMed=19121390

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29292
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     173.13|      41|      41|     885|     925|       1
---------------------------------------------------------------------------
  769-  821 (38.18/ 9.28)	PSSI..TIT.......PITSSQiksmDDRIRSDRKSSK..........SGeerSKEK...KKKRRrddsmGPPEK
  901-  945 (58.61/18.49)	NSPK..HLT.......GYSSPK....NHSISSPKQSSS.........gSG...KPSMsalKSATS.....GSPSA
  946-  992 (41.67/10.86)	KSGT....T.......GYDLTK....K..ISKDNYSSSsstsrdkekkHS...SLSF...SSSDR.....SSPKL
 1098- 1138 (34.67/ 7.70)	PSSDgmKITinktrskESSSSS....KLNYSSSKQSSP..........QL...TP.................PSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     185.79|      38|      38|    1155|    1192|       2
---------------------------------------------------------------------------
  699-  736 (39.21/11.37)	SEMRRSSSSL....lldlTEGK.SY..M.PS.SVSITPIGSSS..ANPQ
  843-  882 (34.77/ 9.22)	SPLRASSPNS..lirkfsPSPT.HGR......SVSITKSPSPStvKGIG
 1155- 1182 (35.95/ 9.79)	..................PASK.KTQAMQSSKSSSLNTSSTPP..KANM
 1183- 1220 (46.29/14.81)	SPSDSSNPNM.....skvPYSK.SS...SSSSSAGINLSKSAS..KSNS
 1292- 1334 (29.57/ 6.69)	KPLDTRNFQIpklkdknsPAAQyENRSMVNDFSRSLD....QN..KYPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     184.77|      30|      30|    1352|    1381|       3
---------------------------------------------------------------------------
 1352- 1381 (53.84/31.18)	YPLNVP...KPLMNLGAMS.PKTT...GKSDQ.SDRPM
 1383- 1403 (28.81/12.04)	YSKATA...DSL..........TK...GGSPQ.RNKDE
 1412- 1444 (36.42/17.86)	YPL.MPldfKTDMAKGFAT.PKGA...PEDRKgADSCM
 1459- 1487 (32.05/14.52)	TPQEAA...EMLLDFSSSSgSKVS...GLV...AVRPV
 1488- 1517 (33.64/15.73)	YPAS.P...ALALQL.AKS.PAPSplvAPSPH.SNSP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.92|      74|     261|      28|     107|       4
---------------------------------------------------------------------------
   28-  107 (113.52/89.58)	KLRSKTPQYKNLTETSKAVRTSMLDKRWGvdNAD...RMILQKCLDSL..QHSIKITSLQ....NLIERLQC..LSRQLGLKLVVgtsgVN
  289-  373 (106.40/68.81)	KLSQPTPLCSGLAKLIQATTEVEVSGDWA..NAKpllGLVVQQAYDKLvpGKNIELNLSKglfvNLPKQTQCyfVCERRGLEGCI....VN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      89.67|      17|     261|    1073|    1089|       5
---------------------------------------------------------------------------
  552-  568 (26.23/12.97)	SEQQH..QLTMMCQDSNES
  572-  588 (20.35/ 8.14)	EERKS..KKRKSDSDVWST
  589-  607 (17.75/ 6.01)	AQKKGkpGLSDMMDSDSES
 1073- 1089 (25.34/12.24)	SEQKN..SLPASGGKTSES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.45|      34|      43|     608|     645|       6
---------------------------------------------------------------------------
  608-  645 (53.39/36.59)	DNSDNYANEDDNTVN..SNSSTEDLEgresSASQNEF.TSD
  652-  688 (50.05/25.76)	DAADALRNQDNRTSSdiDNSNDGDVE....EIMRNSFqKSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29292 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKSPAPSPLVAPSPHSNSPCITDDELIDEGLVGPGK
2) LPSSITITPITSSQIKSMDDRIRSDRKSSKSGEERSKEKKKKRRRDDSMGPPEKVPPKQDPLTKPVSVSIKPTDGSPLRASSPNSLIRKFSPSPTHGRSVSITKSPSPSTVKGIGKPSGTSSHHSSPRHSPVQNSPKHLTGYSSPKNHSISSPKQSSSGSGKPSMSALKSATSGSPSAKSGTTGYDLTKKISKDNYSSSSSTSRDKEKKHSSLSFSSSDRSSPKLKNPMKIKQLEITPVTCDSAVTEPLISPPNIEVNKPNASQARNRKGSLSAVIDKLKSAQHCGGDSDSSSKSSGSSSSVGKFSEQKNSLPASGGKTSESKNQEYMVKPSSDGMKITINKTRSKESSSSSKLNYSSSKQSSPQLTPPSQGSPKTHTGLKPGVISGPASKKTQAMQSSKSSSLNTSSTPPKANMSPSDSSNPNMSKVPYSKSSSSSSSAGINLSKSASKSNSGSPKGSSSDLAKIIRDREREKARTKLMSNSEKSIFSSKSERHSSPSGSRDDVDGDRIKSSKDVNFRVEGLMKPLDTRNFQIPKLKDKNSPAAQYENRSMVNDFSRSLDQNKYPFSHYDNSNKGSESMQKSAYPLNVPKPLMNLGAMSPKTTGKSDQSDRPMEYSKATADSLTKGGSPQRNKDEAKDAYSSS
3) MAKGFATPKGAPEDRKGADSCMKPPASASVARSGATTPQEAAEMLLDF
4) MPSSVSITPIGSSSANPQPPSGAGISSMLC
5) VGGLDPGGEQLKHEPAHPHRALYPHPHHAGAYLSEQQHQLTMMCQDSNESKHQEERKSKKRKSDSDVWSTAQKKGKPGLSDMMDSDSESDNSDNYANEDDNTVNSNSSTEDLEGRESSASQNEFTSDLELSTMDAADALRNQDNRTSSDIDNSNDGDVEEIMRNSFQKSDHKRQKLKSKDSEMRRSSSSLLLDLTEGK
1499
768
1423
719
519
1534
1411
1470
748
716










Molecular Recognition Features






MoRF SequenceStartStop




1) ELIDEGLV
2) FQIPKL
3) KYPFSHYD
4) LAKII
5) LVAVRPVYPASPALALQLAK
6) YPLMPL
1523
1299
1331
1230
1481
1412
1530
1304
1338
1234
1500
1417