<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29278
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | RPVAGGAMDLAYVCEWEKWPKSTHCPSVPLACAWSCRNLVAFTTDLRNDDQDLTRMIHILDTEHPWEVHSISSEHSEPITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESPVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCHIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRSVDEPAVKRPRATGPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSGHALEVHPGLRHLLFLLEYCMVTGYDWWDILLHVQPGMVRA |
Length | 496 |
Position | Tail |
Organism | Equus caballus (Horse) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.066 |
Instability index | 44.73 |
Isoelectric point | 6.57 |
Molecular weight | 54324.98 |
Publications | PubMed=19892987
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | catalytic activity GO:0003824 IEA:InterPro
|
GO - Biological Process | positive regulation of transcription, DNA-templated GO:0045893 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP29278
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 201.99| 49| 200| 82| 131| 1
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82- 131 (82.77/56.35) LEWDQSGSRL.L..SADADGQIKCWSM.ADHL.ANSWESPVGSLVEGD.PIVaLSW
133- 174 (57.10/33.73) ....HNGVKLaL..HVEKSGAS...SF.GEKF.SRVKFSPSLTLFGGK.PME..GW
281- 334 (62.12/37.32) LARDMSEQVL.LcaSSQTSSIVECWSLrKEGLpVNNIFQQISPVVGDKqPMI.LKW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 105.23| 30| 391| 34| 69| 5
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34- 69 (51.85/54.27) WSCRNLVAFttdlrnDDQDLTRMIHILDTEHPWEVH
433- 462 (53.38/40.21) WTSLALVGI......DNHGKLSMLRISPSGHALEVH
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