<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29274

Description Mediator of RNA polymerase II transcription subunit 13
SequenceVNWDISSLPTCFKNNFLQAELTGIKWRRYNFEGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPNCKELWIFWWGDEPNLVDVIHRELHMVEEGLWENGLSYECRTLLFKAIHNLLESQRCLMDKNFVRIGKWFIRPYEKDEKPINKSEHLSCAFTFFLHKSNVCTSVEIAQHLPIYLINEEHLRMAQSSPVPFQVLISPYGLSGTLTGQAYKMSDPATQKLMEEWQYFYPVVLKKKEGFKEEQRYDDDFPVAVEVIVGGVRMVYPSAFVLIAQNDIPISPSTLAPGAHNSMAQQGAGNMKDAHSCGMFLTPPISPEQIVIGDSGSIPSMVSYSAAAPDGMGSVQGSKISEKIPSIFHKRIIQRTWKEWILNKSQSKRAPMMKGGTLTNCAAWDFIDPVKRVYCTCSRHRLFRQRYLGFCRLPSLSHSSSSTSLPFASKHKITERQEKLDKNQKRSLLPFHYRPAVTEELCTEQDPPVHKLTLAGMEPSLEASGIRKYEKPFSLPPRHSSKQSHLNPMDSPHSPASPLPPTLSPQPRGQEAESLYPPSIPVTPILYHSGLELQPLLSTEGRTVHGGQRLPLTEDVGDTGVYSGLVRNQESLNMWQGYTLPSSGNTEFRPPELHCERYDIHVNTPFQSTALKSSPPRLLAQPNKRFKIVEEPSSVPAMHYFDLYPLNRRRPGKGLRDVSDPYTFQDGDIKYSFTRAKKGKLGADREFLKKNKSDDGTGPKDISVAGHSTSMSDGKDAMSIFRSAPKTDTRHDNAATRAGSSSLMQVTDLAPSLHDLDNLFDNSDEDDNEAVSPSHCSKVPLQGTEERSLAKDTRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMCYKDGIGSETLTTLGMLESPAFSMTTNQLTEFKIEVEDGLGSPKPEEIKDFSYVHKTSTFQPFLGSSAFAPLKMLPSQCLLPLKIPEACVYRPSWALPPKTEHLSLPPNTTFIRDGYTNIPSVGSLADQDYLQMNTPQMSTPVTLNSVAPASNGGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTSRPLNSVEPATVQPILEAHSLYVTLILSDSVLNIFKDSNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIVNRKLGYNSGLFIEDELDIFGKTSDIGQIAERRLMLSQSPLTPQLGEGSKKVQEFPISLLLLLQSQHTQPFTSMNCLYYMSATNRQTLPSTNWNYDRVRAESNDSWVECFNALEQGRQYVDNPIGGKVDEALVRSATIHSWPHSNVLDISTLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWETIQHVQGPLTWQQFHKMAGREVRSSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGRQDVAYIVVCPENEALLNGAKTFFRDLSTVYEMCRLGQHKPICKVLHDGIMQVGRTAAQKLTDEVVSDWFNAPWGSEDTDNHSKLKLYAQVCRHHLAPYLATLQLDSSLLMPPKQTTPSSQERTKPGRPMVPSHSTPFAVPGPPPVGSSFTSTPSARTTNLPVGSSSAPRLSASSLAPSIKPANTTSSSGFSSGLPQGQNLAAGANPTERSQGSSLSGGDTEAGHSSSQQNQEGTESTAERERMGVSLDPEPVDSHAYPPAVVIYMVDPFTYTAEEESASANFWVLSLMRCYTEMMDSLPEHMRDSFILQIVPCQNMLQTTKGEQVLYLQHLKSLAFSAYCQCRRPLPTQNHIKSLTGFGPAANTETTLKNPEWPSPIQLYSPPFILAPIKDKQTELGETFGEASQQCNVLFVGYCLSHDQRWLLASCTDVHGELLDTCVINIYLPNSHRSKRSKVSPRKIGLQKLWEWCTGIIQMSSLPWRVVIGRLGRLGHGELKDWSILLGESSLQTISKQLKEVCRMCGISSTDSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPNNDDMFDLPFPEDMDNDIGILMTGNLHSSPTSSPVPSPCSPGVGVGPSFQHSRSQGERLLSREAPEELKQQPLALGYFVSTARAENLPQWFWSSCPHAQNQCPLFLKASLHHHISVAQMDELLPPRNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNLLS
Length2195
PositionMiddle
OrganismAnolis carolinensis (Green anole) (American chameleon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Lepidosauria> Squamata> Bifurcata> Unidentata> Episquamata> Toxicofera> Iguania> Dactyloidae> Anolis.
Aromaticity0.08
Grand average of hydropathy-0.382
Instability index57.57
Isoelectric point6.24
Molecular weight243151.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29274
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.96|      30|      32|    1125|    1156|       1
---------------------------------------------------------------------------
 1095- 1123 (23.71/ 9.23)	...VTLILSDSvlnifkdSNFDSC.CICACN..MN..
 1126- 1155 (55.91/31.38)	GADVGLYIPDS.......SNEDQYRCTCGFSAIVNRK
 1157- 1184 (45.34/23.58)	GYNSGLFIED.........ELDIFGKTSDIGQIAERR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.72|      24|      25|    1570|    1593|       3
---------------------------------------------------------------------------
 1553- 1571 (25.11/11.55)	.....PSARTTNLPVGSSSAPRLS
 1572- 1595 (39.01/23.31)	ASSLAPSIKPANTTSSSGFSSGLP
 1597- 1618 (31.59/17.03)	GQNLAAGANPTERSQGSSLSGG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.65|      21|      25|     999|    1020|       4
---------------------------------------------------------------------------
 1008- 1035 (26.77/14.37)	LNSVAPASNGGAG..........vlpspaTPrFSVPTP
 1036- 1072 (27.88/11.17)	RTPRTPRTPRGGGtasgqgsvkydstdqgSP.ASTPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.02|      23|      23|     429|     451|       5
---------------------------------------------------------------------------
  429-  451 (38.20/21.39)	RLPSLSHSSSSTSLPFASKHKIT
  453-  475 (39.81/22.63)	RQEKLDKNQKRSLLPFHYRPAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.38|      22|      25|     627|     649|       6
---------------------------------------------------------------------------
  627-  649 (38.29/28.28)	PPELHCE...RYDIhVNTPFQSTALK
  652-  676 (34.09/19.38)	PPRLLAQpnkRFKI.VEEPSSVPAMH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.95|      23|      24|    1361|    1383|       7
---------------------------------------------------------------------------
 1361- 1383 (41.19/24.80)	SPEPLPIPTLLVGY....DKDFLTISP
 1384- 1410 (37.75/22.03)	FSLPFWERLLLDPYggrqDVAYIVVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.70|      20|      24|      59|      78|       8
---------------------------------------------------------------------------
   18-   41 (27.10/15.92)	QAELTGIkWRRynfEGHGDCGPII
   59-   78 (38.64/26.34)	QANLLCV.WRR...DVKPNCKELW
   85-  104 (33.96/22.12)	EPNLVDV.IHR...ELHMVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.15|      20|      24|    1957|    1976|      12
---------------------------------------------------------------------------
 1957- 1976 (32.63/17.59)	VFGRSTALNLQSSQLNTPQD
 1982- 2001 (33.53/18.28)	ILVFPTSATIQVAPANYPNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.64|      12|      24|     679|     690|      13
---------------------------------------------------------------------------
  679-  690 (23.41/16.01)	DL.YPLNRRRPGK
  705-  717 (17.23/ 9.42)	DIkYSFTRAKKGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.66|      17|      18|    1880|    1897|      14
---------------------------------------------------------------------------
 1880- 1897 (25.98/21.37)	WRVVIGR..LGRLGHgELKD
 1898- 1916 (23.68/13.46)	WSILLGEssLQTISK.QLKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.44|      14|      24|    1459|    1473|      19
---------------------------------------------------------------------------
 1459- 1473 (23.12/17.17)	KLTDEVVSDWFnAPW
 1485- 1498 (27.33/15.39)	KLYAQVCRHHL.APY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.07|      20|      23|    1671|    1690|      20
---------------------------------------------------------------------------
 1671- 1690 (35.43/22.40)	YTAEEESASANF...WVLSLMRC
 1691- 1713 (32.64/20.03)	YTEMMDSLPEHMrdsFILQIVPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.10|      10|      24|     903|     912|      21
---------------------------------------------------------------------------
  903-  912 (18.03/ 8.16)	LGSPKPEEIK
  927-  936 (17.07/ 7.29)	LGSSAFAPLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29274 with Med13 domain of Kingdom Metazoa
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