<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29273

Description Mediator complex subunit 12
SequenceMAAFGVLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFNDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFSEWTQIITKFLWEQLQKIADYHRQLMAQSSCGSPSNLMPQEVEHSLKQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLAMLLDSTGGHQAHHLSAQAAPPLPSTPTPQPAAGNPPPSPFSDLLLCPQHRPVVFGLSCILQSIVLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGVNTGFMQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGAGPSKDSHEISPDDDAVVALLCEWAVSHKRSGRHRAMVVAKLLEKRHSEIEAERCGDSEVVDEKGSISSGSLSAVNAPVFQDVLMQFLDTQAPMLTEPANENEKVEFFNLVLLFCELVRHDVFSHNMYMCTLISRGDLAIDHGPRPPSPFDDAAEDHDRKEGEGNSGIKLEDTGLSECQMDIDHNSSAIFDDMEKTDFSMFSPPMHCEAKASPSPEKLDPEKESKLLLLKDRAADGLLASLYDQPRHIQYSTHFPIPQEESSSHECNQRLVVLFGVGKQRDEARHAIKKITKDILKVLNRKSTAETGTWPSFSGGEEGQKRKRNKPEAFPTAEDIFAKFQHLSHFDQHLVTSQVSRNVREPPALPLGMSYHLPLQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPLFMIDTIENPSAHNFTYTNLGKSLTDNPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKLLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDSSKPLVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMEDDKKPAGRMVSIETASLEVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSLLELQLMIKQTANNQEMNSLLENIAKATIEVFQQSAETNSASNGIVNLGGSTSLVPTSTKAKPILSSLERSGVWLVAPLIAKLPTSVQGYVLKAAGDELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRKVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVALEPEKKVAEPAKVEKASANTASSAAEPKKKASKNKKRAQPTNKNEDYMMAAGRGVPYGGGMPADLLHHQTANSMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPQIGKLVPSRPPYTGVLPTSMSSMMSIDQAYKSSVYRQQQPPVPQGQLLRQQLQAKLQGQGMVGPQPLRQMAPTPSYGAVQPSQGYTPYVSHIGLQQHPSQSGAMVPPSYSSQTYQNAHPGSNPTFVDPTRTMQRPSGYVHQQAPGYVHSLSAAQRFPHQSMQAAPMMSGVNHMGAQGVPAGIRPSQLLSGQMKQNRKGKRCREQRSQPQRESCVALLQRRKRGIQQIWGHTHTHTHTYIPQQQQQQQPPPQPQPPPQQPQPQPQVPSVPQPQAQGQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQQNSNPFGRY
Length2173
PositionKinase
OrganismAnolis carolinensis (Green anole) (American chameleon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Lepidosauria> Squamata> Bifurcata> Unidentata> Episquamata> Toxicofera> Iguania> Dactyloidae> Anolis.
Aromaticity0.07
Grand average of hydropathy-0.445
Instability index53.38
Isoelectric point7.53
Molecular weight242727.84
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29273
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.41|      26|     109|    1724|    1750|       2
---------------------------------------------------------------------------
 1724- 1750 (43.97/21.80)	PRSYYLEPLPLP...PEEEEPPTPVALePE
 1829- 1857 (41.43/16.91)	PVGLYAQNQPLPaggPRLDTSYRPVRM.PQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.25|      17|     109|     208|     224|       3
---------------------------------------------------------------------------
  208-  224 (29.76/11.01)	QLMAQSSCGSPSNLMPQ
  319-  335 (32.39/12.68)	HLSAQAAPPLPSTPTPQ
 2102- 2114 (23.10/ 6.76)	....QQPPPQPQPPPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.40|      30|     109|    1253|    1297|       4
---------------------------------------------------------------------------
 1066- 1095 (57.18/29.25)	ILCAELTGYCK.....LLSAEWLG..VLKALCCSSNN
 1253- 1289 (46.21/54.41)	IETASLEVYAKyvlrsICQQEWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     260.43|      51|     227|    1893|    1944|       6
---------------------------------------------------------------------------
 1893- 1944 (91.53/49.51)	QQQPP.....VP.......QGQLL.RQQLQAK..LQGQGMVGP....QPLRQMAP..TPSYgAVQPS...QGYTPY
 1950- 1994 (46.40/19.24)	LQQHP.....SQ.......SG.................AMVPPsyssQTYQNAHPgsNPTF..VDPTrtmQRPSGY
 1996- 2047 (53.27/23.29)	HQQAPgyvhsLS.......AAQRFpHQSMQAApmMSGVNHMGA....QGV........PA..GIRPS...QLLSGQ
 2116- 2170 (69.24/32.71)	QPQPQ.....VPsvpqpqaQGQFQ.RQGLQQT..QQQQQTAA......LVRQLQQ..QLS..NTQPQ...QNSNPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.37|      83|     227|    1358|    1454|       7
---------------------------------------------------------------------------
 1132- 1234 (107.15/51.28)	LLEDLIRcAAIPSLLNAACSEQDSEPgarltcriLLHLFKTPQLNPcQQDSSKPLVgirSSCDRH...LLAASQNRIVDGAVFAVLKAVfvlGDaEL.KGsgfSHPG
 1362- 1448 (127.23/81.52)	LLENIAK.ATIEVFQQSAETNSASNG........IVNLGGSTSLVP.TSTKAKPIL...SSLERSgvwLVAPLIAKLPTSVQGYVLKAA...GD.ELeKG...QHLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.11|      48|     229|     228|     296|      11
---------------------------------------------------------------------------
  229-  289 (67.33/82.60)	SLKQWDYNEKLAMfmfqdGMLDRHEFLTWVLECFEkirpGEDELLKLLLPLLlqYSGefVQ
 1451- 1498 (83.78/42.69)	SRKERDRQKQKSM.....SLLSQQPFLSLVLTCLK....GQDEQREGLLTSL..YSQ..VQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.58|      32|     229|     369|     402|      12
---------------------------------------------------------------------------
  369-  402 (55.94/37.86)	IVLCCpsALVWHYSLTD.....SRIKTGS.PLDHLPIAPS
  597-  634 (49.64/27.13)	VLLFC..ELVRHDVFSHnmymcTLISRGDlAIDHGPRPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.20|      19|      23|    1637|    1659|      13
---------------------------------------------------------------------------
 1639- 1659 (25.75/28.61)	ItCEPQGSLIDTKgNKIAGFD
 1661- 1679 (34.45/17.80)	I.FKKEGLQVSTK.QKISPWD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29273 with Med12 domain of Kingdom Metazoa
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