<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29269

Description Mediator of RNA polymerase II transcription subunit 13
SequenceVKMSSCFVPNGASLEDCHSNLFCLADLTGIKWKRYVWEGPTSAPILFPVTEEDPILSSYSRCLKADVLSVWRRDQRPGRRELMIFWWGDDPNFADLIHHELADEEDGVWENGLSYECRTLLFKAIHNLVERCLMNRNFVRIGKWFVKPYEKDEKPVNKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYFVSEEHLTLAQQSNSPFQVILSPFGLNGTLTGQSFKLSDSATKKLIGEWKQFYPITSNLKEGLEEKQEEMDWEDDSLAAVEVLVAGVRMVYPACFVLVPQTDIPTPSAPGSSNCLGVHQVPASTRDPAMSSVTLTPPTSPEDVQTVDARSAQKWVKLSSVSDAFSSDSTSHHGGRIPRKLANQVVDRVWQECNMNRALTKRKYSATSNGLCEEETVDKIAFWDFVEATQRTNCICSRYTSFRYSCRIVVQKPTSISQKGLQQGTVPPVGQQQQAVAKHKANEKPEKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVITASDSQVRFSNLRTSDVAKTPQMHGTEMATSPQPPPLSPHPCDVADEGATKTPSTPQNQHFYHMPTPDPLVPPKAMEDRIEGLSQTFPAPFPEVIEPTMYVGTAVNLEEEDTDSTWKFYKVPKRKDMDFLPPQLPSEKFRDSYPLKPRLFLLYRLMVQCRKPLKVSDELVQQYQSKNQYLAAIVADQEPEMDPYAFVDGDEDFPFPDKKDRQNSEREVGKKHKDNNNKKTSNLTDDGAPNVGEDAMSLFSPSVKQALDAQRIPPHNRTASTSLFHENDLVVSYTDLDNLFNSDEDELTAVSEPSVPGSKRMLNGTDDKSNCKESKAGNLDPLSCIKTGTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLDGNGTTAGIQFRIEVDEGFCSPKPSEIKDYSYVYKPENIQPFVGCSMFAPLKTLPSQCLPAIKLPEECIYRQSWTVGKLELLPPGPTMPFIKEGYVYVVWIFTTYNIYRQTQRQFNIFQLHEGRLDSGHRTCALVTPESLMVLLPHSFPHAAGSFYCGLSNIYSESEEYISRRDSKMKSCRLNNTFFSHTSDMSIVSVYPSFWIKSLRPDQSVFCWKFLLLTSCATDQCDIFLLSKIIWLHYLQKQVSHNTNKVFCCIGSHAGHFPNYYIIVIIIIIETQQDESTRDTLLAVVLDHTSDTSPVIIVLLLLLLLLLETQQDESTADTLLAVVSDHTSDTSQVIILLLLLLLLLLLLLLLLFETQQDESTADTLLAVVLDHTSDTSQVIILLLLLLLLLLFETQEDKSTADTLLAVVLDHTSDTSQVIILLLLLLLLLLLFETQEDKSTADTLLAVVLDHTSDTSQVIILLLLLLLLLLFETQQDKSTADTLLAVVLTLDKRDSTVFDFAVSHPESPSGEMKMGYNIIITVESHLSKPGLSKPFLYNYYITLLRIELLFLSNLLYNMMFWCLICLIDFSLIPPYYPRYSLIQASAGPFSLDKQLQLPNDKINPTNSQIWAYRVSSIMLKLKEVISFLSFSSRSSQLVPCQYLLQPVKNEDRHIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMEMALKSPERPECIKLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDMYGELLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMSSVPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASSTYTTETGLELAFNTNNVGIFELLGTADDLDPDIINILPASPTGSPVHSPSSHFTHGGDMGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQLYNFIMNML
Length2016
PositionMiddle
OrganismAnolis carolinensis (Green anole) (American chameleon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Lepidosauria> Squamata> Bifurcata> Unidentata> Episquamata> Toxicofera> Iguania> Dactyloidae> Anolis.
Aromaticity0.08
Grand average of hydropathy-0.194
Instability index49.15
Isoelectric point5.53
Molecular weight226046.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29269
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     387.98|      37|      37|    1267|    1303|       1
---------------------------------------------------------------------------
 1161- 1196 (52.73/31.19)	...IIVIIIIIETQQDESTRDTLLavVLDHTSDTSPVII
 1197- 1234 (71.08/44.80)	VLLLLLLLLL.ETQQDESTADTLLavVSDHTSDTSQVII
 1247- 1279 (58.45/35.43)	......LLLLFETQQDESTADTLLavVLDHTSDTSQVII
 1280- 1318 (75.13/47.81)	LLLLLLLLLLFETQEDKSTADTLLavVLDHTSDTSQVII
 1320- 1358 (75.13/47.81)	LLLLLLLLLLFETQEDKSTADTLLavVLDHTSDTSQVII
 1359- 1395 (55.45/33.21)	LLLLLLLLLLFETQQDKSTADTLLavVLTLDKRDSTV..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     629.41|     206|     267|      74|     340|       2
---------------------------------------------------------------------------
   82-  331 (320.08/284.75)	LMIFWWGDDPNFADLIHH......ELADE.EDGVWEnglsyEC..RTLLFK....AIHN.LVERCLMNrnfvRIGKW.FVKPYEKDEKPVNKSEHLSCSFTFFLHGDSNVctSVEINQHQPVYFVSEEHLTLAQ........QSNSPFQVILSPFGLNGTLTGQSFKLSDSATKKLIgewkqfypIT........SNLKEGLEEKQEEMDweddslaavevlvaGVRM.VYPACFVLVPQ.TDI......PTPSAPGSSNclgVHQVPasTRDPamssvtLTPPTSPED
  344-  588 (309.33/193.23)	VKLSSVSDAFSSDSTSHHggriprKLANQvVDRVWQ.....ECnmNRALTKrkysATSNgLCEEETVD....KIAFWdFVEATQRTNCICSRYTSFRYSCRIVVQKPTSI..SQKGLQQGTVPPVGQQQQAVAKhkanekpeKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLV........ITasdsqvrfSNLRTSDVAKTPQMH..............GTEMaTSPQPPPLSPHpCDVadegatKTPSTPQNQH...FYHMP..TPDP......LVPPKAMED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     343.76|     117|     896|     593|     738|       3
---------------------------------------------------------------------------
  612-  738 (179.30/147.39)	GTAVnLEEEDTDSTWKFyKVpkRKDMDFLPPQlPSEkFRD.SYPLKPR.........LFL.LYRLMVQCRKPLKVSDELVQQYQSKNQYLAAIVADQEPEmDPYAFVDGDEDFPFPDKKDRQNserEVGKKHKDNNNK
  887-  960 (72.55/26.89)	GGTV.LDGNGTTAGIQF.RI..EVDEGFCSPK.PSE.IKDySYVYKPEniqpfvgcsMFApLKTLPSQCLPAIKLPEECI..........................................................
 1567- 1632 (91.91/39.90)	...................................................................QCRRPLPTSTN.VKTLTGFGPGLAMEMALKSPE.RPECIKLYAPPFILAPVKDKQT...ELGETFGEAGQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.16|      42|     812|    1051|    1132|       4
---------------------------------------------------------------------------
 1007- 1048 (78.74/31.15)	NIFQLHE...GRLDSGHRTCAL....VTPESLMVLLP..HSF....PHAAGSFYC
 1052- 1106 (55.42/88.88)	NIYSESEeyiSRRDSKMKSCRLnntfFSHTSDMSIVSvyPSFwiksLRPDQSVFC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.44|      12|     230|    1459|    1471|       5
---------------------------------------------------------------------------
 1459- 1471 (22.01/18.67)	WCLiCLIDFSLIP
 1692- 1703 (25.43/16.13)	WCL.GLVQMSSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.04|      16|     811|    1107|    1132|       6
---------------------------------------------------------------------------
 1116- 1132 (26.59/30.78)	ATDQCDIFLLSKiIWLH
 1930- 1945 (30.44/ 9.51)	AQNQCPLFLKAS.LHLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.19|      13|     588|     809|     821|       8
---------------------------------------------------------------------------
  809-  821 (24.56/13.58)	AVSEPSVP.GSKRM
 1399- 1412 (21.63/11.00)	AVSHPESPsGEMKM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29269 with Med13 domain of Kingdom Metazoa
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