<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29256

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGSNAKSSGTGFGSHIPSIEEKNKQIQQETMMEKLRAKYRNKPKSYEEIKKSVRMYFIEKHYPLDPLCKATLQSALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQLLFISTDMFYVEILLDAAGSLSDVKVHHECKIEQQSSELVACLKSGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIQSLYQLHLQGHSGDSYSLMTSSSVGLVLPRRGGHPMRLTYFCPPLHLPEGDPKLASGDFTIDQVMRSSYGLSATINLEGSSANKLQTLPTVTLVRDAQTGLEVPTYAQLNQNNSLLMPATFVLRLNKPMPVCLESLKALGLPGLDSVATPPGPPTTVLNLIVQTASKQAIKNTQRGLYVNLPKETHCYFFTDNRKLQGTLVSSLPFTEPAQVPRIVAFLKKQALFYTLLASCVREQQKQYNDMDSTVILEVTAVSFNQITVELQHPYEESLATVDFLLEDGQPTCSVYCLTNEYELLSQKLTRTARKVVSIPMVIYKLLKCWDEEHEFKLHGAIGPGSGSGAIGGGGMSGGGPVSGVGNNFSQFSMDTPTPSDGSLPGGGFANINNLKMDAKSRSLADAFAASTSAAAAIAGLINLKRETDPQSGSSASGTTVSGSSSSSGSAKTSDHDIADKYKNIWKDKTPNLKHCVSITPIPGDGKSGSAGGVSGVEVQRTGGIEIIPLNAQAAIAGGGVTASSSATPTTITITPITGKDPSKDSTKKSTAASAGVGVAAKRPHESSTSSSSTSGCSGSGSSMSSSASSGSSDTQKEKKRKKKRDDSPMGPPEKIYSRQNSPAGGADASATGGVVRKFSSPSSSPKAGGGGQGLMAGVPTARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAATILSPKGDKSSSAVGNTSSGPSASSGSSGATGLVRSFASVGAPPPPPPIPPLASSSGSISSSQSLKKEKTSSASGSSSTSSSATAGVASGGGISPASVAAAVAALKSSQQQMKSVASLSHLAAGGGLGSYAAPSGAGASGAAAVVVGAGAGAGAGASGLELSALRKGMAGGAVSPFSL
Length1080
PositionMiddle
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.262
Instability index51.57
Isoelectric point9.26
Molecular weight111517.46
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867
PubMed=26109357
PubMed=26109356
PubMed=25589440

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29256
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     164.92|      29|      30|     562|     590|       1
---------------------------------------------------------------------------
  533-  560 (27.97/ 6.73)	....PGSGSGAIGGG.G.MSGggpVSG...VGNNFSQ
  562-  590 (45.08/15.80)	SMDTPTPSDGSLPGG.G.FAN...INN...LKMDAKS
  734-  760 (29.67/ 7.63)	D..STKKSTAASAGV.G.VAA...KRP...HESSTSS
  829-  856 (29.36/ 7.47)	SS..PSSSPKAGGGGqGlMAG...VPT...ARPSPK.
  872-  900 (32.83/ 9.31)	SPKSPF.GTHS.PKH.G.SSG...KPSmstLK.SAAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     235.11|      59|     140|     623|     683|       2
---------------------------------------------------------------------------
  643-  716 (73.51/21.65)	SDHDIADKYKNIWKDKTP..NLKHCVSITPI.PGDGKSGSA.GGVsgvevqrtggieiiplnaQAAiAG..GGVTASS....SA
  782-  824 (38.22/ 8.48)	SDTQKEKKRKK.KRDDSPmgPPEKIYSRQNS.PAGGADASAtGGV.......................................
  933-  985 (66.95/21.95)	TG..LVRSFASVGAPPPP..P.....PIPPLaSSSGSISSS.QSL..................KKE.KT..SSASGSSSTSSSA
  996- 1055 (56.43/16.14)	SPASVAAAVAAL.KSSQQ..QMKSVASLSHL.AAGGGLGSY.AAP................sgAGA.SGaaAVVVGAGAGAG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     258.67|      84|      95|     155|     247|       3
---------------------------------------------------------------------------
  155-  247 (124.78/98.31)	LKSGdfaDFTVQlEGLSSIYQLNAEPKVKKKAFVALQAMET.....DIQSLYQLHLQGHSGDSYSLMTSSSvgLVLprRGGHPMRLTYFC.PPLHLPeG
  251-  340 (133.88/78.02)	LASG...DFTID.QVMRSSYGLSATINLEGSSANKLQTLPTvtlvrDAQTGLEVPTYAQLNQNNSLLMPAT..FVL..RLNKPMPVCLESlKALGLP.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.95|      19|     140|     621|     639|       4
---------------------------------------------------------------------------
  622-  639 (30.95/10.50)	GSSASGTTVSGSS.SSSGS.
  761-  779 (25.33/ 7.18)	.SSTSGCSGSGSSmSSSASS
  912-  930 (34.67/12.69)	SSSAVGNTSSGPS.ASSGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.54|      33|     321|      41|      77|       5
---------------------------------------------------------------------------
   41-   77 (51.18/58.83)	RNKPKS.YEEIKKSVRMYFIEKHYPLdplcKATLQSAL
  368-  401 (54.37/46.69)	KNTQRGlYVNLPKETHCYFFTDNRKL....QGTLVSSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29256 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKHCVSITPIPGDGKSGSAGGVSGVEVQRTGGIEIIPLNAQAAIAGGGVTASSSATPTTITITPITGKDPSKDSTKKSTAASAGVGVAAKRPHESSTSSSSTSGCSGSGSSMSSSASSGSSDTQKEKKRKKKRDDSPMGPPEKIYSRQNSPAGGADASATGGVVRKFSSPSSSPKAGGGGQGLMAGVPTARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAATILSPKGDKSSSAVGNTSSGPSASSGSSGATGLVRSFASVGAPPPPPPIPPLASSSGSISSSQSLKKEKTSSASGSSSTSSSATAGV
2) RETDPQSGSSASGTTVSGSSSSSGSAKTSDHDIADKYKN
662
615
989
653










Molecular Recognition Features






MoRF SequenceStartStop




1) LELSALRK
2) LKSAATAAT
1061
895
1068
903