<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29249

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSPGSPSNSKNYNSNNSNNNSNNRFYQQQQQQQQYHFQQQQQQLQYQNQHQQFLFQQQQQNYHRQQHSLLHHHHHHHHQAYQQNTINPANQQQQLTPRLQTNPSYPQPLIHHRQLQKNNSSSSKQHSPNYLRSQAQLIPNGSPLPLPPPPIIPQTVSTTTNQSNRHHHHQQQQQQHRQNHHHRDSNRRNYRQSSFRTNLTLPHHPSLPKPPNPERSQTIPLLSLTNNQTQAHQQQQQQQQQQQQQHPHPHHPHHHPQPSTSSTTTPTTTPTSSSFSKSNTNNPNSSTHIRHIHSPSTSTLQSSLPPDEQLGLGGPQAAGYFSPSAIELNPWRGCSPCKWKVPLLNTGLPNSPARDHTNLATIDEELDQTHSSVSHLEQDEWKIRWAKLSLVAQQEASHDQLKPQIANQLHSLRLHFVFDSEGQQSVQGLVVWVYEIPGRLGPKQSYEQPPPLIDPILKTYQTFENHTPIINQPSPIKACQSVISYGVLSYSQLFPNLFTRSTTSNSKPLLPHLSHPAKNRTANDFLVDDSSQTNTIPAYANLLRALNQHIITLAVQSPDSTPFPGACPTRWIRWGPDRLLSVPRDDSLEHLYRNLNRDSTRLMGAILTTAPALVVELKSWLSSRVAMCQPSFTARRLAPMPPLPQHNIPPGFPLILAPFPNLRAQYVRMFGRFNHSLVRCKSGTSSQSSNFSSTRSSWLSDSPSIPNASWISQQKRICRAELKHFEKLKQTWRLAAPFMEAYPETHPTSATNANQRNFESWVVCKITTNNSEAVNPETNDSQEIELVWPVDHCLLDLESWIESAEQNPPPPPTESDPPASLTPSSRICFPRARLANSLMISAYEPTDELAENAGSYIDWVAQERELQRRAAAAAGKEKTPQKTESPPSMTGGRAGLGLNRGRGSGYPSPRFQRHTSTSTARASPVPPHLITPRMSKKRLRDDGDDRSSSQNSTIFPPSIIPFDCGIVTASDRGDSATVDFASNGLSDENGMDIYHDSTATNLPDPPTSQPQEECSISTVIRDEQQPLSNDTLHQSSSVVLAPSSQPGTTSYQFVSAQQGSGSGSTASTISYNTNLFEQPTPGSVSISGLTPGRLNGFTPDANNNFNNNFNNNNNNHPSTQTAHYSSPINQNHHSTTTDPAGPSEADQLAISENALRTLSLMSSSDSGPSDKLFRFVEPVGYESVRFSHTHTVVDDHYTRRGGKYALPPSPHSFSSPEDEQGDDALDIVDQEVLRRARGPLLVHVSKKLMRAIDPRAKVARTLFNSAFRTSDSQQSFSRAEPLTSSAIALTTQGGTGYTESPATPRSWVPIGSSNDSSDGSTFSEDEDEPDGNEFIRSIDARDRGSYSSTTSSCSSDDERIMAIDREYQHAIAAKIEQIERSLKDVLEIQYRSKFFSIQPSSNHSSRPPQNLSPEDRTIKPKHIPPAVRKKLKNWVSQLATQLEHDPNLEVLLETVLPSTSSPKVTTNDTRKTTEDYRVVLDLASMPIINGFDYYRPLVDDEYEIQENRTQNSTTQKKKAEEEEEKEEKKKLGKQQMKVKEVEEGDQRPYLIKKFTKAPASIVVKINEGKQKIAFSLISQLFKYWIKLGFEPVSGQRDSVLSVIFPRPLPRHAHQPKTNSKDPSLVDSGAETLFVNSQQDKHPLSHLNLPSIHHWLLELAHTYKSCRLGELSIGKIHEKMKSLGVGEREIVGLDGRPVTRLLISRHQLLDDRPASLISFAMRLYDSMKIHVHRFTAPGLSFDPYLTPAPIRPGECQPPSESEDSSSDAGELPDRAGQLHHSTDEHKQPRTDGRSRHRRPSDRKLLSGHAFFLTGIQKPTQLNIRWPPSGIDVSARHRMLHIGYLVGPQRAWVLVSMVDELGQQHQLVLKFPASPASSDSSLPSHAPAQKQKASLSRELDEHRLEMQIVSSVWKVSRKIILSTNVEWRVVITKLGRIKPIEYEAWCELLSQTLPASEVAFHVTLSSVMMSDVPMLRRVGAGEGPSTTRLSTTRRESVTEGGGGGEGASDLEMGEVEGPEEGEEGVGDRAEGVEEGGGGGGVEKLGGGPEPVWVVHESTLRPHSSFDPQSPSSSMPRSVNATIVHSLSSSYIYSHQCPVSPGSLDSFPSGTTPSGRGGRFRVDLLGTAASPASVYQANLFQHREEIVHSLVLLSRLKHLRSSSSSSSQHHPSHSGPSDRPSTDVDVDEDDDETKAAGADLALLPGHLSSLIVLARLLNSHLHRLSDLFLLDQTHLPSALLSPSAFKQHDLDGQLDPFNHQLDQLDPLILLHN
Length2269
PositionKinase
OrganismPuccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) (Black stem rust fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.06
Grand average of hydropathy-0.739
Instability index56.99
Isoelectric point6.81
Molecular weight252410.28
Publications
PubMed=21536894

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
chromatin binding	GO:0003682	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29249
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.66|      15|      15|      29|      43|       1
---------------------------------------------------------------------------
   40-   57 (25.18/10.40)	QQQQlqyQN....QHQQFLFQQ
   58-   79 (21.64/ 7.83)	QQQNyhrQQhsllHHHHHHHHQ
  236-  246 (19.84/ 6.51)	QQQQ...QQ....QQQQH....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.40|      13|      15|    1682|    1696|       2
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 1682- 1696 (14.75/16.11)	LGVGeREIVgLDGRP
 1700- 1712 (23.65/12.84)	LLIS.RHQL.LDDRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.77|      27|      68|     804|     833|       3
---------------------------------------------------------------------------
  804-  821 (23.06/10.32)	....................................................AEQNPPPPPTESdPP......ASL
  822-  896 (19.61/10.69)	TPSSRicFPRARlanslmisayeptdelaenagsyidwvaqerelqrraaaaAGKEKTPQKTES.PPsmtggrAGL
  906-  927 (23.10/ 6.35)	YPSPR..FQRHT....................................ststARASPVPP................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.84|      14|      18|    1047|    1064|       4
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 1047- 1060 (24.70/ 7.61)	GTTSYQF.VSAQQGS
 1067- 1081 (21.14/12.37)	STISYNTnLFEQPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     618.34|     164|     193|     266|     457|       5
---------------------------------------------------------------------------
   94-  214 (194.18/76.70)	.............QL.................TPRLQTNPSY..PQPLIHH......rqlQKNNSSSSK..Q..............HS.PNYLRSQ.AQLIPN...............GSPLPLPP....PPI...IPQTVSTTTNQSNRHHHH....QQQ.QQQHRQ.NHHHRDSNRRNYRQSSFRTNLTLPHHPSLPKPPN...............PE
  215-  421 (230.24/132.35)	RSQTIPLLSLTNNQTqahqqqqqqqqqqqqqhPH...PHHPHHHPQPSTSSTTtPTT...TPTSSSFSKsNTNNP..NSSTHIRHIHS.PSTSTLQ.SSLPPDeqlglggpqaagyfsPSAIELNPwrgcSPCkwkVPLLNTGLPNSPARDHTNlatiDEElDQTHSSVSHLEQDEWKIRWAKLSLVAQQEASHDQLKPQIANQLHSLRLHFV...FDSE
  422-  558 (193.92/76.59)	GQQSVQGLVVWVYEI.................PGRLGPKQSYEQPPPLIDPILkTYQ...T.....F...ENHTPiiNQPSPIKACQSvISYGVLSySQL...........................................FPNLFTRSTTS.........NSKPLLPHLSHPA.KNRTANDFLV..DDSSQTNTIPAYANLLRALNQHIItlaVQSP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.75|      12|      18|    1977|    1993|       6
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 1977- 1988 (21.83/ 6.00)	GAGEGPSTTRLS
 1998- 2009 (20.91/14.13)	GGGGGEGASDLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     475.92|     157|     193|    1089|    1274|       8
---------------------------------------------------------------------------
 1089- 1266 (237.63/171.93)	LTPGRLNGFT..PDANNNFNNNFNNNNNNHPSTqtahYSSpinqnhhstttDPAGPsEADQLAISENALRTLSLMSSSDSGPS........DKLFRFVEPVGYESVRFShTHTVVDDHYtrRGGKYAL.PPSPHSFSSPEDEQGDDAlDIVDQEVLRRARGPLLVHVSkKLMRAI..DPRAKV.ARTLFNSA
 1289- 1459 (238.29/133.90)	LTTQGGTGYTesPATPRSWVPIGSSNDSSDGST....FSE...........DEDEP.DGNEFIRSIDARDRGSYSSTTSSCSSdderimaiDREYQHAIAAKIEQIERS.LKDVLEIQY..RSKFFSIqPSSNHSSRPPQNLSPEDR.TIKPKHIPPAVRKKLKNWVS.QLATQLehDPNLEVlLETVLPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.03|      16|      17|    1764|    1779|       9
---------------------------------------------------------------------------
 1763- 1778 (26.57/12.53)	SSSDAGELPDRAGQLH
 1779- 1794 (28.46/14.00)	HSTDEHKQPRTDGRSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.40|      17|      17|    1515|    1531|      10
---------------------------------------------------------------------------
 1515- 1531 (25.15/17.42)	QKKKAEEEEEKEEKKKL
 1534- 1550 (27.24/19.54)	QQMKVKEVEEGDQRPYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.42|      26|     193|    1845|    1876|      12
---------------------------------------------------------------------------
 1845- 1876 (39.42/31.44)	GPQRAWVLvsmVDELGQQHQlvlKF.PASPASS
 2045- 2071 (47.00/23.09)	GPEPVWVV...HESTLRPHS...SFdPQSPSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.19|      57|      62|    2097|    2157|      13
---------------------------------------------------------------------------
 2097- 2157 (95.85/61.99)	SPGSLDSFPSGTTPSGRGGR.FRVDLLGTAASPASVYQANLFQHreeiVHSLVLLSRL..KHLR
 2160- 2219 (90.33/50.14)	SSSSSQHHPSHSGPSDRPSTdVDVDEDDDETKAAGADLALLPGH....LSSLIVLARLlnSHLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.44|      12|      17|    1015|    1026|      16
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 1015- 1026 (21.01/10.63)	SISTVIRDEQQP
 1035- 1046 (20.43/10.11)	SSSVVLAPSSQP
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.04|      14|      15|     679|     692|      18
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  679-  692 (25.24/12.83)	RCKSGTSSQS.SNFS
  695-  709 (21.80/ 9.84)	RSSWLSDSPSiPNAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.53|      10|      21|    1643|    1652|      20
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 1643- 1652 (18.30/10.21)	LSHLNLPSIH
 1667- 1676 (17.24/ 9.11)	LGELSIGKIH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29249 with Med13 domain of Kingdom Fungi
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