<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29245

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTALEFPNNCSTNVYTLNDFGEIAYIVCTVATPPNHDSAAIPTPGSTLARLRKTERQFREASILAALDVDTCQLFTFYKKVDIANARDQKTLLSKFGYVLRSNTCTIAYKTAARLPDLIKPEQARLYRLFTTAVVSSIKLLPNGDSALQPVGPNVYLVEGTPSDGLDWPQSSRRWSLYSVDLQIITSGHVILTLGKHASMSFLRLLEVYGDSARARRLSEQSAAVYLVPGGQVARLIRREAGDKSNKTGKPGQRLEQGQALDIWKGVWKELLPQWLKENMNMTIDEDVVWIEAEVPLQEVDASTPTDQTSPRLREAGDGQIMWRPVYWPASLCFVVDDQNDTPLETPKSDADPMQFVQDWLTGTGQQSGVGLKSGKLQHETLEDDDEPLFADDGPFDVPEHLQSFGPPAFPNSHSIYPTPPDVTMTHHTPGLSSVDGIGVTPANFALGPSETAKQHDTEMQDFGVVSASSQLANFDDEDLFEEIPDANFDQEGNGDEPNWDFFDQPGIGNKSNPMVTSHRDDFISITSENHEERNELEDSFTRGDAEMEVSGRTSGLDDPSDAERPSTLQEIMEARSASPVKGGSISHKDEAGGRPTSSKRTGSPRPVRGTQPNPSGRRRGSSIYDGVQGATTLSNHDRKYTADGDYWFDPNPAIPTPKNISAHTAVFHMSSSTSSESGSSVDGHDASVALDNAEQKSPPIPRKWTEYQPGSPPTTGQADEVRRESINLEAQQLLDLLKVSLVEPPSPSDFQLHKALRNIQGVTPSKLLQVAQILVEQVSQTSLMKAGHYIDRLPETSNDYMEVNIDLSGINTFTQASTVQQLINIKPDSTSTNCKGRVLKLPTSQICVRRADQPLFASASIMEFWDTLNLQPESGAKVVTAFCLHPSGGSVAEGCSNFLQRMTDTYNSCALGKHSTGRIPGVTEDGLCAWGWNVHSQGDFHKTCRRFGRALAQASDLHDTIIVYMVARDKSVESYLQTCEAFLSLFESFRQSLGDRQNSFDVALQIVPLSFIADPETLVVPPQSAYVKLAIEVYNRIPPGELSGSPAAGGSAVVLAQPENSVHFRLSPTFSSPLSKYGPCLHLAYSVTADHRWITAAWTDELGRVALSMTYCLRKQNSPRERPRREIFQEMWEISHDIMGKMHSTWRLAIAREGYYEPAELQDWEQVIKGPSPPHKQCLALLISIQLQPALRVFPPSMQTKTGPQGMQNTYGTPASTPQASITSPDQLVPATPTPGGSSIMSVPTPNEPGFDPNTDSDLTLVDPTEESWGIILPYGVNQTANMVDLRPALVSCMLIKRKGTKVEDGCLAIEVNLISTLSAAIESAETSTDGLLEDLMTQYRRLVTLAMTRGCVDPLHECVPWHIITAAKGSHALDKVL
Length1380
PositionKinase
OrganismExophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.403
Instability index47.63
Isoelectric point5.07
Molecular weight151348.97
Publications
PubMed=24496724
PubMed=28348446

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29245
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.97|      16|      16|     930|     945|       1
---------------------------------------------------------------------------
  911-  929 (18.21/ 9.23)	C.ALG..KHSTGRIpgvteDGL
  930-  945 (34.50/25.42)	C.AWGWNVHSQGDF.....HKT
  946-  962 (22.27/13.26)	CrRFGRALAQASDL.....HDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     351.46|     106|     184|     968|    1081|       2
---------------------------------------------------------------------------
  968- 1070 (142.94/88.53)	................VARDKSVESYLQTCE...AFLSLFESFRQSLGDRQN.SFDVALQIVPLSFiaDpetlVVPPQSAYVKLAIEVYNRIP....................PGEL.......SG.SPAAGGSAVVLAQPENSVHFRLSP
 1073- 1197 (157.47/86.90)	SSPLSKYGPclhlaysVTADHRWITAAWTDElgrVALSMTYCLRKQNSPRERpRREIFQEMWEISH..D....IMGKMHSTWRLAIAREGYYE....................PAELqdweqviKGpSPPHKQCLALLISIQLQPALRVFP
 1198- 1255 (51.05/19.73)	PSMQTKTGP....................................................................................qgmqntygtpastpqasitsPDQL......vPA.TPTPGGSSIMSVPTPNEPGF..DP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.92|      20|     183|      38|      62|       3
---------------------------------------------------------------------------
   38-   62 (30.04/25.42)	DSAAI.PTPGSTLARLRKterqfREA
  222-  242 (30.89/15.10)	QSAAVyLVPGGQVARLIR.....REA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     564.34|     132|     184|     298|     431|       4
---------------------------------------------------------------------------
  298-  408 (165.86/86.31)	.....................................................LQEVDASTPTDQTSPR.LR.EAGdGQIMWR....PVYwPASLCFVVDDQNDTPLETPKS...DAD.....PMQFVQDWLTGTGQQ.....SGVGLKSGKLQHETLEDDD..E.PL....FADDGPFDVPEHLQSFGP
  409-  506 (103.04/46.09)	PAFPNSHSIYPTPPDVTMTHHTP.........................................................................................glsSVDgigvtPANFALGP.SETAKQhdtemQDFGVVSASSQLANFDDEDlfE.EIpdanFDQEGNGDEP.NWDFFDQ
  507-  652 (155.83/73.52)	PGIGNK.....SNPMVT.SHRD.dfisitsenheerneledsftrgdaemevsGRTSGLDDPSDAERPStLQ.E.....IMEArsasPVK.GGSISH.KDEAGGRP.TSSKR...TGS.....PRPVRGTQPNPSGRR.....RGSSIYDGVQGATTLSNHD..R.KY....TA.DGDYW.......FDP
  654-  755 (139.61/65.09)	PAIPTPKNISAHTAVFHMSSSTS.................................................sESG.SSVDGH........DASVALDNAEQKSPPIPRKWT...EYQ.....PGS.....PPTTGQA.....DEVRRESINLEAQQLLDLL..KvSL....VEPPSPSDFQLH......
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29245 with Med13 domain of Kingdom Fungi
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