<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29243

Description Uncharacterized protein
SequenceMTLNPPAEPRPPPLRRPPDAHRSALSGPTTKAHTPIERRAPSLQKKNDLHEDVRPAKRRKIEGDSTTSQASSASNETPVAQSPGSFHDPNVPRLRLVKPVVLNTDDHFGQGQQEGDDDYGDEVPELPARPWSHVQQSRKPEDPKPTHRSRVKIPVPNTPDSLRLPSSAPYIVSKKPAGYFPWTGKHPEDVLSESNVKQGFYDKPPNPPEKELNTAKGPLYNAFKHKAGVENLSLLFSFVLERKNRHGLISSASTFRPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIRGQVLLDQCLQGSVPLNRAIWFAKCVCANEIRTLKRKGTTPAIAVGTESKWLREWTVSVEQFVAAHLEQTKQQEWISNIEYALRLTTRLYMENLLDRDHYLDWILRSFHTADLAHTPFWLMVIHIYKEDLSYYRKRGRKLAEALADKFQLVNKPSALNTTSLRQKLRHTVRWLILAWPKCFLMPEKWPQIVDSVRACLDATSQHETQLLERLDFINARTMGQNKQASTTKHTAREMVVEILDSTHDSYELPKLAEQLSAACGDTTQLMTTCLEWVCTRFRHCRSRIYLFARLARRWQRMGHDIDNIILNYLSDCRNGCYADTVDQKALQHLAAQLSRSGLFPLAKYMQWLMVRGLPQKGALGSGLDSVSDNLENQADPSHLLLHVSLHNVKDHVINLRNSVLRGCGFNPESEDNVFHDCVQYIEQELASLAPGRKPSRVRKPEPAFSSIPWTVKSRLSMWLRGKVAEWARAIGNAPGGSAAPALPGSRVFNVEQFALVRKVLERMEDDAVLADVIGLLSSSPDEDVIAALVATIHFHADVFSAIGAFEVLQHRMCQVYLTWRASRPTMPLFTSTLLDLCTAYPVKAPTTRLLQQDFVKGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSEPNMNEQTMNGLFAVLVDRIEKQQKFGYDSETVVSFCHLLSRLRLCRRVQGDSLIQKWVARLVPSVDGNFGALLLQSLVGTHCTTFVGLVGVISESNSGVWKSPAARILLQHISLPTEGSLPDLVEYRARSRWLEYVQEYPSSALEILYEIGLESALAPIEKALLSSLVKDDTFRTSTISPAAQQWLLAALDRLLCRGAAGKTGDMRALVGSMNVFSHRFVQLRFWLASRTMPDQSTGYDQDELVQVLSEMLGRMLQEPPGSEEGHRWYAQLLESVDVGVANQLRHQVESEFLEALPKSLPNKAASPVTALFSSDVHHLSSITERAYLLCTSSTSPMPGFMAQLIDKLMQHLKALGVNPLAPASSTAAGPSPSPINTSAPQMMAPTYSPAAGSSEAGYGVISGMIMGHFRYLLQMVCLQRLALCSAVAPGANAKQAQAEQAQLLVRLASIATHPAITTAATDSADPEDQQKVKEVLDFTFDVMATIIDNVGDEVRMMGAKALKDKLQDRRMRHLFGSVNMMGSTQVRDVGQGLQMIKEGKGVLGDWKPRVWEILDNGSAKESETSLGLGLFGARHK
Length1505
PositionKinase
OrganismExophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.295
Instability index52.65
Isoelectric point8.63
Molecular weight167422.59
Publications
PubMed=24496724
PubMed=28348446

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29243
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.38|      18|      51|      88|     106|       1
---------------------------------------------------------------------------
   88-  106 (29.83/25.71)	DPNvPRLR.LVKPVVLNTDD
  142-  160 (32.55/22.63)	DPK.PTHRsRVKIPVPNTPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     237.67|      67|     191|    1106|    1177|       2
---------------------------------------------------------------------------
  832-  870 (29.55/12.23)	............................DVFSAIGAFEVLQH.RM.CQV....YLtWRASRpTMPLfTSTLLD........
 1106- 1177 (111.73/88.38)	STISPAAQQWLLAALDrllcrGAAGKTGDMRALVGSMNVFSH.RF.VQL....RF.WLASR.TMPD.QSTGYDQDELVQVL
 1302- 1373 (96.39/64.56)	SPINTSAPQMMAPTYS.....PAAGSSEAGYGVISGM.IMGHfRYlLQMvclqRL.ALCSA.VAPG.ANAKQAQAEQAQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.48|      48|     191|      10|      74|       3
---------------------------------------------------------------------------
   10-   38 (42.05/18.82)	.....................RPPPLRRPPDAHRSALSGPTTKAHTPIER
   39-   58 (12.48/27.33)	RAPSLQKKNDlHEDVRPAKR..............................
  236-  284 (74.95/51.05)	FSFVLERKNR.HGLISSASTfRPPPRVTLTEAKRKSWIADLANADVPLRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.22|      21|     559|     165|     185|       4
---------------------------------------------------------------------------
  165-  185 (42.84/28.65)	PSSAPYIVSK.KPA.GYFPWTGK
  725-  747 (32.38/19.55)	PGRKPSRVRKpEPAfSSIPWTVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.47|      18|      21|    1423|    1440|       9
---------------------------------------------------------------------------
 1423- 1440 (31.62/21.81)	VRMMGAKALKDKLQDRRM
 1447- 1464 (32.85/22.96)	VNMMGSTQVRDVGQGLQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.47|      57|     298|     883|     942|      10
---------------------------------------------------------------------------
  883-  942 (94.44/63.14)	RLLQQDFVKGDRGRAVAACSPYSD.GIAESL.QQAGATFvedFEAILQSEPNMNEQTMNGLF
 1183- 1241 (91.03/53.88)	RMLQEPPGSEEGHRWYAQLLESVDvGVANQLrHQVESEF...LEALPKSLPNKAASPVTALF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.99|      16|      17|     973|     988|      11
---------------------------------------------------------------------------
  973-  988 (30.39/24.45)	RLCRRVQGD...SLIQKWV
  990- 1008 (21.60/14.60)	RLVPSVDGNfgaLLLQSLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.82|      14|      15|     795|     808|      12
---------------------------------------------------------------------------
  795-  808 (22.13/13.22)	LERMEDDAVLADVI
  811-  824 (21.69/12.81)	LSSSPDEDVIAALV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.45|      14|      17|     619|     632|      14
---------------------------------------------------------------------------
  619-  632 (22.67/10.74)	KALQHLAAQ.LSRSG
  638-  652 (21.78/10.04)	KYMQWLMVRgLPQKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      13|     362|     581|     600|      16
---------------------------------------------------------------------------
  567-  581 (22.21/22.39)	WvcTRFRHCRSRIYL
  589-  601 (25.82/ 8.91)	W..QRMGHDIDNIIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29243 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTLNPPAEPRPPPLRRPPDAHRSALSGPTTKAHTPIERRAPSLQKKNDLHEDVRPAKRRKIEGDSTTSQASSASNETPVAQSPGSFHDPNVPRLRLVKPVVLNTDDHFGQGQQEGDDDYGDEVPELPARPWSHVQQSRKPEDPKPTHRSRVKIPVPNTPDSLRLPSSA
1
168










Molecular Recognition Features






MoRF SequenceStartStop




1) PDAHRSALSGPTTKAHTPIERRAPSLQKKNDLHEDVR
2) RLRLVK
18
93
54
98