<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29242

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGERPTANGEHFSNGIQQDTLKAEQSGGEIKKEHYSSGFSAPGGEQTPQSHAANGDTHANDPSKDDSKTGVDEAPTDILNLIPKDHYLPIAALIGRAAQSCWNGLTELVEELASIQVPEQPAEQTKVLPNNLPNNQTRENLDKKERLLRFANDQKADFIKLLVLLQWSKNVEDVSKTISINFWLMKRRQAYWDVIASLAALKQESAGFQIPNPDLKGAAEVLSTGRMRNFPTLGYIPQKDLSDKQILRILRTLDRSLSVRLTLSDDLPPQLRRYRVHDGRVTFTVANEFEVDLSVLDDKPDAPFRMVDFRFGFSPSPHIPDHLRAEIELYANTNIDRDGLRGCYLFLHELTLSYKLAEFHKQAVELARGQWTGNLRVEMIRRNLVIQYWPERPIGKSWIEIGIASGRTKKSGQTQDAIPFLEIKSIRQGKRAEALHLHLDDSVVSFEDVLRQIIAQHSVQILNSIYDKLVPTPLFANAELLLEQTSSEKDPEECQLTMQVSQSSRVQIKVEPVTGVLLISPVSERSERLQYELNRIQGVPEEIVSKLLNFRCSVREASVLAGITATSWEALKAFKFNQAELKALFGSPVVRINMFRQLPWGLDYTLAVTHGQAGDHWWLLQQLSSSGVNLQPRFRVIRSQRIEIAEELSAEHFEQLAEYATGLICLQRNVDYLKQKGEKVELPPLPTFGRTYTLPEISYDLDLSRPAFAGKDTSAPKAAHPEASEPAMAANSSRSMKLRFGGLDRAMSKVTMIGQFQTHASSAVLKHIDSSILDPDVTLNYEDRAVSIRIDTAVAEPGVPEIVAKAVDVEKTVSTVEQIHRLPGLQLKNLSKSAFTITYHADPPKEYGLTMTFTRGSDVPRLEFLPPEDNPHTLLNEFYSKHFAAGRSSFSSQVRDFFTSLTVTLPLLTFLCRLQDRHGLDSKDTQVPSTADGQKSALRVHVLPRTTTAFALQYFTAAGQAPSDVAGPGSNPHMLARLEILPHLNVPEKPMWLVRAALEDFQSYSRPSYSSPALRNKLRQEIFSRTDNGGKWLALDTAAVCKADAPETLLQAIHDLFCTWVKERMAGEGEVDNISNKQQQQQQQTGRPNNMAPNNLNLNAATTGGTMPNLSLPAKFSQSVKAPLSAANKMQQAQQQQKQQQQPHFGMNMNMNGPPPNGAIKATPHQWPPPSANLMNMGRNTSGSNNAAAKGNSSSGGGNNPQGNKDVITID
Length1212
PositionTail
OrganismExophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.444
Instability index47.83
Isoelectric point6.69
Molecular weight134711.90
Publications
PubMed=24496724
PubMed=28348446

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29242
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.59|      36|      44|    1124|    1159|       1
---------------------------------------------------------------------------
 1077- 1111 (41.51/20.05)	.....NKQQQ.QQQQTGRPNNMAPNNLNLNaattgGTMPNL
 1124- 1159 (69.09/38.24)	PLSAANKMQQAQQQQKQQQQPHFGMNMNMN.....GPPPNG
 1169- 1204 (59.00/31.58)	PPPSANLMNMGRNTSGSNNAAAKGNSSSGG.....GNNPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.12|      15|      45|     861|     875|       2
---------------------------------------------------------------------------
  861-  875 (30.96/18.08)	PRLEFLPPEDNPHTL
  907-  921 (26.16/14.05)	PLLTFLCRLQDRHGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.16|      40|      46|     457|     502|       3
---------------------------------------------------------------------------
  455-  494 (66.55/58.96)	IAQHS.VQI.LNSIYDKLVPTPLFANAE.LLLEQTSSEKDPEE
  501-  543 (52.61/31.06)	VSQSSrVQIkVEPVTGVLLISPVSERSErLQYELNRIQGVPEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.62|      33|      52|     621|     654|       4
---------------------------------------------------------------------------
  621-  654 (51.01/39.15)	LQQlSSSGVNLQ..PRF.RVIRSQRIEIAEELSAEHF
  674-  709 (48.61/32.29)	LKQ.KGEKVELPplPTFgRTYTLPEISYDLDLSRPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.62|      20|      46|     776|     798|       5
---------------------------------------------------------------------------
  776-  798 (29.55/30.17)	PDVTL.NYEDRAVSIridTAVAEP
  824-  844 (32.08/22.38)	PGLQLkNLSKSAFTI...TYHADP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.55|      25|      29|     258|     284|       9
---------------------------------------------------------------------------
  258-  284 (40.32/28.27)	LSVRLTLSDDLPPQlrRYRVHDGRVTF
  290-  314 (46.23/26.60)	FEVDLSVLDDKPDA..PFRMVDFRFGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.71|      12|     692|     316|     328|      10
---------------------------------------------------------------------------
  317-  328 (23.46/19.53)	SPHIPDHLRAEI
 1012- 1023 (21.25/ 9.29)	SPALRNKLRQEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.54|      20|      32|      33|      52|      11
---------------------------------------------------------------------------
   33-   52 (36.64/27.39)	KEHYSSGFS.APGG..EQTPQSH
   65-   87 (23.90/14.68)	KDDSKTGVDeAPTDilNLIPKDH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29242 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EGEVDNISNKQQQQQQQTGRPNNMAPNNLNLNAATTGGTMPNLSLPAKFSQSVKAPLSAANKMQQAQQQQKQQQQPHFGMNMNMNGPPPNGAIKATPHQWPPPSANLMNMGRNTSGSNNAAAKGNSSSGGGNNPQGNKDVITID
2) MNGERPTANGEHFSNGIQQDTLKAEQSGGEIKKEHYSSGFSAPGGEQTPQSHAANGDTHANDPSKDDSKTGVDEAPT
1069
1
1212
77










Molecular Recognition Features






MoRF SequenceStartStop




1) GGEIKKEHYSSGF
2) TLKAEQ
28
21
40
26