<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29238
Description |
Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MSDAKDDLTDKAHFDPTWIAWNGGYLHSNNVLFYFATSPFFDQVSGNQSLFTQWAGTPNQNDILGTRAKFEANLRHQRGIQYVVQHDPLEEKVMVDGPNGRENSNVWVIRKQNRENEDDRSVTVLGYYYIVNDVIYQAPSVANVLNYRMLNTVLSLDKVFSTPADLSYFSPAHGHTYHKPVQKSLAQSISGPSQQSKESTPMPTSQASSSEKPTGGPVQPHEDSNGEARTVWDALRMTLQYGKEYMDEVPLVGEPGHFRFSRQKDLTNGHAKGLAAPSNVGTPGQSRAPSAVPPITTGPTSAPKDAKNGEKVGAAPDAPPKPKRRKSRPGDSSP |
Length | 334 |
Position | Head |
Organism | Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.761 |
Instability index | 42.09 |
Isoelectric point | 7.17 |
Molecular weight | 36704.24 |
Publications | PubMed=24496724
PubMed=28348446
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP29238
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.12| 21| 36| 161| 182| 1
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161- 182 (36.65/20.54) STPADLSYFSPAHGHTyHKPVQ
199- 219 (39.47/18.03) STPMPTSQASSSEKPT.GGPVQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 111.58| 33| 37| 261| 294| 2
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261- 294 (56.76/35.48) SRQKDLTNGHAKGlAAPSNVGTPGQSRA.PSAVPP
301- 334 (54.82/30.12) SAPKDAKNGEKVG.AAPDAPPKPKRRKSrPGDSSP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.41| 14| 44| 79| 98| 3
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60- 73 (22.60/17.57) QNDILGTRAKFEAN
85- 98 (24.81/ 9.41) QHDPLEEKVMVDGP
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