<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29236

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMHEFALYGLVSKDDHHRMLQQLAGYTRMQPQHTIEIHLVFKPRTPAGLERLPSAGGTQGVLQQDVQKLKNMLNAGLYYLQLVGEVVPPPKLKGTEKGDVAMSDANGDANPTKSTPGTAVVNWHLDFKDTPEPGKQAVSTRLISRIPINDGDYIQFMNNFGYEYVSRYLVVGDNFYDYDTTLFVHKVLRLPQVSADGAIADTSFLSNISELPKLDGSGGYMLQASIDVVDGNHPELKERATRQLLGHKEALKQAVELTPGDRLALDTRLPVSSGRA
Length275
PositionHead
OrganismExophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.377
Instability index33.79
Isoelectric point6.13
Molecular weight30326.03
Publications
PubMed=24496724
PubMed=28348446

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29236
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.90|      18|      20|     178|     196|       1
---------------------------------------------------------------------------
  178-  196 (26.95/23.19)	DTTlFVHKVLRLPQVSADG
  200-  217 (30.95/21.44)	DTS.FLSNISELPKLDGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.73|      24|      26|      46|      69|       2
---------------------------------------------------------------------------
   19-   41 (24.32/13.73)	..LQQL..AGYTRMQPQHTIEihlVFK
   46-   69 (40.67/27.88)	AGLERLPSAGGTQGVLQQDVQ...KLK
   74-   92 (32.74/21.02)	AGLYYLQLVG...EVVPP..P...KLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.73|      18|      20|     103|     120|       3
---------------------------------------------------------------------------
  103-  120 (30.21/19.31)	DANGDANPTKSTPGTAVV
  125-  142 (30.52/19.58)	DFKDTPEPGKQAVSTRLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.04|      18|      26|     221|     238|       4
---------------------------------------------------------------------------
  221-  238 (29.59/19.34)	LQASIDVVDGNHPELKER
  250-  267 (28.45/18.34)	LKQAVELTPGDRLALDTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29236 with Med18 domain of Kingdom Fungi
Unable to open file!