<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29235

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDHPEDFAPEAFFDQNPLQQIQHIDPATDLGSVPNVSLPPNLAVIEQLHRRWYSGCLERVAWSRLGHLASISEDGCTVYLECLLYEHDAKTWRLNERHALTTIFEDAVSLAWSSTGAELAVVDIKGRVWVYTASHVAINRLVLGRRGDLDEPGESSQPIGMTWLNQDRQDRPKNVVVLAAKNDSRWVHTNARAKPLGPYWPRAVVVVHRSGLLTLCFQRADGQYSRINTHLSPHDNTLYTHASFAPTVEGKLLIALHSFKHQISVRFLSIDWTGVRQSPGTLPVLTVDFVSAKVASQPTGSATLGDVYDPDSWRLTHVEVVPTSDVEKAVQTPPTILAVASGINRGVNITDHGYLVSSMIKRWTVTLVEQKLHPLFDQLPSKGTNKTTSPPVYTFQRQPDKEEQIVTRVHPMEGHAALVVTTQEGRTDFLNPEDLSPVSYAASVTETSSLAQAGFIFPFVPNAPFPAFSPSACIRADITPEGKTQIVTMEHTLDHGQEAQQPLDPNIDVAIAALNLSFARACWTNATIDDILMCALHNIPASFRPVIVSSMYRALFRDNEFVSERTQGSELERVFHKQVMGRVMAYHAGLTAYCPQLPTIAPTEGRTGWSLSAQWAWMANNIRHTATLLFMNLRDVQNLNLVMTQDFTDMLCSNLRWGLSVVRFIISTILEVGDRETNPDMFDSKDIGRVGDTKGDGSQGLVALLLNIHCSRQFLVAFVRAVRAYAKSTEPKSQHHVQVLQCIQQQTVNKGITFPAVEALLEARWPSPGDIEGDIPGTAVRQLDMMATGTVHPAYEGTIKLILNKLLNSPAGLRAKNLIDRLKLYTDHVDLDYVFLNRHVLGHLEDQSKETPVIYDVHRKRPILKGGPDPSGTGVLMVRRCVRCGSFSEDINVALKEWPKQVGGLLARCVCDGQWVLEAWKGDGE
Length925
PositionTail
OrganismExophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.08
Grand average of hydropathy-0.179
Instability index42.76
Isoelectric point6.22
Molecular weight102750.83
Publications
PubMed=24496724
PubMed=28348446

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29235
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     838.63|     341|     464|       7|     398|       1
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    7-  259 (296.15/254.08)	......................................................................................................................................................................................................................FAPEAFF..DQNP..LQQIQHIDPATDLGSVPNVSLPPNLAV.IEQLH...RR..WYSGCLERVawsrlghlasisedgctvyLECLLYEHDAKTWRLNERHALTTIFEDAVSLAWSSTGAELAVV...DIKGRVWVYTASHVA.......INRlVLGRRGdldepgeSSQPIGMTWLNQD.R..........QDrPKNVVVLAAKNDSRWVHTNAR..............................akplgpyWPRAVVVVHRSGLLTL........CFQRAD.GQYSRINTHLSPHDNTLYTHASFAPTVEGKLLIALHSF
  260-  398 (82.94/84.40)	KHQISVRFLS.IDWTGVRQSPgTLPVLTVdFVSAKvasQPTGSATLGDVydPDSwRLTHVEVVPTSDVEKAVQ.TPPTI....LAVASGInRGVNITDHGYLVSSMIKRWTVTLVEQKLHPLFDQlpSKGTnkttsPPVYTFQRQ........................................................................................................................................................................................................................................................................................................................................................................................................
  468-  725 (263.30/163.02)	.................................................................................................................................................pdkeeqivtrvhpmeghaalvvttqegrtdflnpedlspvsyaasvtetsslaqagfifpfvpnapfpaFSPSACIraDITPegKTQIVTMEHTLDHGQEAQQPLDPNIDVaIAALNlsfARacWTNATIDDI...................LMCALHNIPASFRPVIVSSMYRALFRDNEFVSERTQGSELERVfhkQVMGRVMAYHAGLTAycpqlptIAP.TEGRTG.......WSLSAQWAWMANNiRhtatllfmnlRD.VQNLNLVMTQDFTDMLCSNLR.....................................WGLSVVRFIISTILEVgdretnpdMFDSKDiGRVGDTKGDGSQGLVALLLNIHCSRQFLVAFVRAVRAY
  732-  914 (196.23/122.49)	KSQHHVQVLQcIQQQTVNKGI.TFPAVEA.LLEAR...WPSPGDIEGDI..PGT.AVRQLDMMATGTVHPAYEgTIKLIlnklLNSPAGL.RAKNLIDRLKLYTDHVDLDYVFLNRHVLGHLEDQ..SKET.....PVIYDVHRK..............................................................................................................................................................................................................................................................................................rpilkggpdpsgtgvlmvrrcvrcgsfsedinvalkeWPKQV.....GGLLAR........CV..CD.GQ....................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29235 with Med16 domain of Kingdom Fungi
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