<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29233

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDSVVLAPLDSLESHLNSLITSLTQTNTFTNAPQIARDLVSDDDNLTASLNLLQRHQQNYARILNLRAEVVNLQEQLRDTIRQCVALRQEIGHIHPSILDSLDSDADGAEADQDTDSKVAEVDYQTLLSFAARIGKHNAAAAREAEAEAIRRKIAARNKASTATTTTNGVGPDSVGGKGDANENATAETEAELERINNTIALTRAQMGMAFPDANLLRVGALGQLQLLQERQQHTASTGGDGGDAEAQAAIDREVERMVRDTEDIAEPEHEADVPEEEHREWPSPEMSRRSIGGDGRPSGSQARGSITAHAPAPSQQPKRKLDLDFPSSDDEE
Length333
PositionMiddle
OrganismExophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.02
Grand average of hydropathy-0.668
Instability index50.85
Isoelectric point4.66
Molecular weight36047.98
Publications
PubMed=24496724
PubMed=28348446

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29233
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.48|      18|      18|      53|      70|       1
---------------------------------------------------------------------------
   53-   70 (31.24/20.67)	LQRHQQNYAR.ILNLRAEV
   73-   91 (24.25/14.59)	LQEQLRDTIRqCVALRQEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.84|      13|      51|     237|     249|       2
---------------------------------------------------------------------------
  237-  249 (24.46/15.22)	STGGDGGDAEAQA
  291-  303 (25.39/16.08)	SIGGDGRPSGSQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.99|      39|      46|     138|     179|       3
---------------------------------------------------------------------------
  138-  179 (58.63/42.82)	NAAAAREAEAEAIRRKIA.ARNKASTATTTTNGVgpdSVGGKG
  184-  223 (62.36/36.99)	NATAETEAELERINNTIAlTRAQMGMAFPDANLL...RVGALG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29233 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRRKIAARNKASTATTTTNGVGPDSVGGKGDANENATAETEAELERINNTIALTRA
2) LGQLQLLQERQQHTASTGGDGGDAEAQAAIDREVERMVRDTEDIAEPEHEADVPEEEHREWPSPEMSRRSIGGDGRPSGSQARGSITAHAPAPSQQPKRKLDLDFPSSDDEE
150
222
205
333










Molecular Recognition Features






MoRF SequenceStartStop




1) AIRRKIAAR
2) EHREWPSPEMSRRSIGGDGRP
3) QARGSITAHAPAPSQQPKRKLDLDFPSSDDEE
149
278
302
157
298
333