<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29232
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSDSKTISLLIPSEAPAQSQDWSIQIQKIVAQKGHFRHVTERGLVSRTKDKAVDSQEKQAANEIQGENEDETRQKHQESLWKGREQMLERLSYAQNEILCALDFISLLISKQSVPAQSSMSPALKEAVPVGTLAARMLKPKPLPSSVQQRLALTSEGWRLQSFRSASKKLSEASSRLRSDAERQTEYWAQIAGLTAAGWAVSRVPRDSKAVGVHFGFPESAPQFRDRGFALLRQSEDGSVTLDKHALRGKRKWLHVYVSRDGVRTGAFSPKRPTKSHSESISEQLTELRDSMFEEELFYEICREARIVANQGVSTRAQAVDLEVGDGCRISLLFSEKPDTEVAGNADANTIAEFVATSLRLLLTAAHEQNLAKRSHKPLPMTIKPRPLPEYTLIRPILTHLRHKAEAASFWGDCRTLLRPFVQAGVPVSIVPAGSGNDLSQPLHTETPYSILSGLMHPAQAACKVTLTGERIMTVDLHTFLGPPLHGSRYETSSLDFGFSNLPHLHHETKEAVMLFLRRVLLLDLVKHTQDLALESQDVQNSDHDTLRKWTLCRPHHGEFALYKSGEVVEKMKIGILPDSVNIRWSSLDKGTTSRQVLWSWTASGCTKADGAEVWPHVETTFDEAIGQIIKG |
Length | 632 |
Position | Head |
Organism | Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.402 |
Instability index | 49.56 |
Isoelectric point | 8.33 |
Molecular weight | 70395.15 |
Publications | PubMed=24496724
PubMed=28348446
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP29232
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 56.98| 16| 39| 153| 168| 1
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153- 168 (28.54/14.44) LTSEGWRLQSFRSASK
194- 209 (28.43/14.35) LTAAGWAVSRVPRDSK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.63| 27| 39| 417| 444| 3
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417- 444 (43.67/30.25) LLRPfVQAGVPVS.....IVPAGSGNDLSQPLH
455- 486 (44.95/26.27) LMHP.AQAACKVTltgerIMTVDLHTFLGPPLH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.42| 13| 96| 7| 19| 4
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7- 19 (24.17/14.80) ISLLIPSEA.PAQS
105- 118 (19.26/10.37) ISLLISKQSvPAQS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.14| 23| 50| 536| 558| 5
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536- 558 (44.73/27.81) SQDVQNSDHDTLRKWTL..CRPHHG
587- 611 (37.41/22.15) SLDKGTTSRQVLWSWTAsgCTKADG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.93| 22| 109| 281| 303| 6
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281- 303 (34.79/31.00) ISEQLTELRDSMfEEELFYEICR
394- 415 (42.14/31.55) IRPILTHLRHKA.EAASFWGDCR
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