<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29232

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDSKTISLLIPSEAPAQSQDWSIQIQKIVAQKGHFRHVTERGLVSRTKDKAVDSQEKQAANEIQGENEDETRQKHQESLWKGREQMLERLSYAQNEILCALDFISLLISKQSVPAQSSMSPALKEAVPVGTLAARMLKPKPLPSSVQQRLALTSEGWRLQSFRSASKKLSEASSRLRSDAERQTEYWAQIAGLTAAGWAVSRVPRDSKAVGVHFGFPESAPQFRDRGFALLRQSEDGSVTLDKHALRGKRKWLHVYVSRDGVRTGAFSPKRPTKSHSESISEQLTELRDSMFEEELFYEICREARIVANQGVSTRAQAVDLEVGDGCRISLLFSEKPDTEVAGNADANTIAEFVATSLRLLLTAAHEQNLAKRSHKPLPMTIKPRPLPEYTLIRPILTHLRHKAEAASFWGDCRTLLRPFVQAGVPVSIVPAGSGNDLSQPLHTETPYSILSGLMHPAQAACKVTLTGERIMTVDLHTFLGPPLHGSRYETSSLDFGFSNLPHLHHETKEAVMLFLRRVLLLDLVKHTQDLALESQDVQNSDHDTLRKWTLCRPHHGEFALYKSGEVVEKMKIGILPDSVNIRWSSLDKGTTSRQVLWSWTASGCTKADGAEVWPHVETTFDEAIGQIIKG
Length632
PositionHead
OrganismExophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.06
Grand average of hydropathy-0.402
Instability index49.56
Isoelectric point8.33
Molecular weight70395.15
Publications
PubMed=24496724
PubMed=28348446

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29232
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.98|      16|      39|     153|     168|       1
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  153-  168 (28.54/14.44)	LTSEGWRLQSFRSASK
  194-  209 (28.43/14.35)	LTAAGWAVSRVPRDSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.63|      27|      39|     417|     444|       3
---------------------------------------------------------------------------
  417-  444 (43.67/30.25)	LLRPfVQAGVPVS.....IVPAGSGNDLSQPLH
  455-  486 (44.95/26.27)	LMHP.AQAACKVTltgerIMTVDLHTFLGPPLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.42|      13|      96|       7|      19|       4
---------------------------------------------------------------------------
    7-   19 (24.17/14.80)	ISLLIPSEA.PAQS
  105-  118 (19.26/10.37)	ISLLISKQSvPAQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.14|      23|      50|     536|     558|       5
---------------------------------------------------------------------------
  536-  558 (44.73/27.81)	SQDVQNSDHDTLRKWTL..CRPHHG
  587-  611 (37.41/22.15)	SLDKGTTSRQVLWSWTAsgCTKADG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.93|      22|     109|     281|     303|       6
---------------------------------------------------------------------------
  281-  303 (34.79/31.00)	ISEQLTELRDSMfEEELFYEICR
  394-  415 (42.14/31.55)	IRPILTHLRHKA.EAASFWGDCR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29232 with Med17 domain of Kingdom Fungi
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