<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29230
Description |
Cyclin H |
Sequence | MAADYWTSTQRTYWTFTPEKLSSIRDDLERANAKTIEQFPFPDRRLMFIFLRDRLLQLGKRLPFRQQCMATALVYLHRYFLSTPMQNVNIYLLVATAFYLSSKTEESPHHIRLVAAEARQAWPELMPGDVFRLGEMEFCLISEMRSQLIVWHPYRTLIALKENQDLRLTNDELGLAWSIINDSYMTDLPLTCPPHLIAIIAMLLAVVFLPTAKASGTLRPISHESLVNPDSSAGPFSSLVGRHGQNLSGSFSAAVGNLQMSNNNQQFGQHSVNNNQGKSRAAQESSTTDRDKDKTIVAAIKDSEKLQNIITFLVESGIDVEQVINGIQEMISLYSVWEEYNEKTVREAVARCIKGRGLDG |
Length | 360 |
Position | Kinase |
Organism | Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.213 |
Instability index | 43.32 |
Isoelectric point | 6.27 |
Molecular weight | 40733.08 |
Publications | PubMed=24496724
PubMed=28348446
|
Function
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The SRB8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II.
Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The srb8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II.
ECO:0000256 ARBA:ARBA00002306
ECO:0000256 ARBA:ARBA00003882
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP29230
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 54.68| 17| 17| 79| 95| 1
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79- 95 (29.64/18.95) YFLSTPMQNVNIYL.LVA
98- 115 (25.04/15.06) FYLSSKTEESPHHIrLVA
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