Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MAKPTSKTGRGGRGATRVSDTAKTNNTSSSTPPNTNQTQTTVAKRTRSGVRKAVQTSESVEATTSSTNLNVGTTTPETQLEEGINPPEKHNRPASTFVSLRVPSEGLRRSAASRGPFVTLKLAPSALRSVVEKSGSPSSANTPTSSQATDDYELVTGTAAAIGPSRELYQTDNHLGAGLVEGESTATTSDRATSPTTLDSRQTHSTLVAPHSQEVAASSQAMAPVKDTSSVHNTIKDIIQELTDIQIQTHGYVPETQDLLVDKMTELAESLSRLQNLTSTTASPNSYIHNVQIAPEIVDYVDDGRNPDIFTRDFVENVQRGNAVINGKQHAFAEFAKIYAKALKEGIPGVASQVDKVLANAGLELEPEEKANPGADADYSSINGVHKAEGI |
Length | 391 |
Position | Middle |
Organism | Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.564 |
Instability index | 39.09 |
Isoelectric point | 5.66 |
Molecular weight | 41404.02 |
Publications | PubMed=24496724 PubMed=28348446 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | kinase activity GO:0016301 IEA:UniProtKB-KW transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29228 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 57.57| 17| 17| 5| 21| 1 --------------------------------------------------------------------------- 5- 21 (28.06/14.37) TSKTGRGGRGATRVSDT 24- 40 (29.51/15.47) TNNTSSSTPPNTNQTQT --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.15| 13| 24| 154| 166| 5 --------------------------------------------------------------------------- 154- 166 (21.81/10.58) LVTGTAAAIGPSR 179- 191 (21.34/10.21) LVEGESTATTSDR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ASRGPFVTLKLAPSA 2) MAKPTSK | 112 1 | 126 7 |
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