Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MAELSTDQVRALDQTRQRLLALQTSLIALRSDITTQSSLPSWPALQTHANLISNNLQTIAAQLAEHREAFQSTVAFPLPQFPGKERAFILETLLRTKLEPNVEDWVEEGESIALRLRKGDPSGISEADLNALWQWAPTAANKEARKQKWGADFTLEEKQRGVSNVVTGLRRELVEPPDEEDEEGDEDEEYEVTDEEEEEDDGNKMEVEQTKSENKPGGTTESATVLRTATQMPLQSVHKFMVTGR |
Length | 245 |
Position | Head |
Organism | Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.733 |
Instability index | 62.37 |
Isoelectric point | 4.55 |
Molecular weight | 27499.10 |
Publications | PubMed=24496724 PubMed=28348446 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29227 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 128.15| 45| 74| 61| 110| 1 --------------------------------------------------------------------------- 61- 110 (66.49/46.20) AQLAEHREAFQST..VAFPLPQfpgKERAF..ILETLLRTKLEP.NVEDwvEEGE 136- 185 (61.66/30.30) APTAANKEARKQKwgADFTLEE...KQRGVsnVVTGLRRELVEPpDEED..EEGD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ESATVLRTATQMPLQSVHKFMVTGR 2) IALRLRK 3) KMEVEQTK | 221 112 204 | 245 118 211 |
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