<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29206

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMLVCCKLEPELARNRQNAPNLPVPGDARQVEEYVFQKCMSKDEYMRTIAKVINAINCNSKSAAVPPALQPSPFHPPTGGAAGGGGQSGPGSAGRPAIPPDPQPTQAAARAAAAAAAAGGGAGAASVMAPPLGQPPPQMGSGAVSAGGGALSAAPPGGGSASMDDAMGGMQPAGNAQQMQQPFNPYGAPPQHAMHQQQQQHYQLQQQQHQQQAAAAAARSKAAAAAAAQMRAASAQPPPQQQPMHYGGMPGGAAPPPHNPYAQNPYGQMQPQPQHGYGGMGMGPGAPVDMGGVGGGSAGGGAALPAANTPEYQIMYNNKLRTLRPHCDNLRAKAQQCRIDGNAEAAGKLETMIGVLEGRRSVSLEYLGNLETWILRKADFLAHSPANMHGAHGTGGAGGMGGPPSGGGPMSEALSASMMLDQGQGPPPGMGGYGMPHPYGMQPQPQPQQHHMMGGWGMHPQMGMAGPGAGTGPQPHHLMMPPQQQHVGGGPMHAHAPYRGADAAEMSRPYPSAHMRPMPGHHTMGGGPPGMHMGAPGGPGGMLAPGQPPGVGGSGLDDLYSMDDILPTPSLEGGTQGASGAKPRLAEAAMRECHAISDRFEVEPLAERKIASHVVLKCKLKTHQIPPLRLLVPNMYPQGQVSVDREEIDITAYMYDDLQSSVYDRLARPGLRTITDFLDTWNSFVRLGIGSDKESTVRQWYLAQPPQGGSGAPGPSYGGGPPGGPAPGGGGGGTPMDSNNYDDLFSQYDDIINS
Length753
PositionTail
OrganismPristionchus pacificus (Parasitic nematode)
KingdomMetazoa
Lineage
Aromaticity0.05
Grand average of hydropathy-0.526
Instability index60.94
Isoelectric point6.54
Molecular weight77359.26
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29206
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     267.56|      33|      33|     428|     460|       1
---------------------------------------------------------------------------
  247-  284 (46.49/ 9.29)	GMpGGAApPPHnpyaqnP.YG.QMQPQ.....PQ..HGYGGMGMGPG
  395-  426 (47.37/ 9.66)	GA.GGMG.GP.......P.SGGGPMSE.....ALSASMMLDQGQGPP
  428-  460 (79.76/23.22)	GM.GGYG.MPH......P.YGMQPQPQ.....PQQHHMMGGWGMHPQ
  462-  494 (47.47/ 9.70)	GM.AGPG.A...........GTGPQPHhlmmpPQQQH.VGGGPMHAH
  707-  734 (46.47/ 9.28)	G...GSG.APG......PsYGGGPPGG.....P....APGGGGGGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     192.59|      33|      33|      95|     127|       2
---------------------------------------------------------------------------
   63-   95 (47.14/11.15)	AV..PP.ALQP..SPFHPPTG..G.AAGGGGqSGPGSAG.rP
   96-  129 (54.37/14.23)	AI..PP.DPQPTQAAARAAAA..A.AAAGGG.AGAASVM.aP
  130-  163 (44.57/10.06)	PLgqPP..PQMGSGAVSAGGG..AlSAAPPG.GGSAS.M..D
  508-  544 (46.51/10.88)	PY..PSaHMRPMPGHHTMGGGppG.MHMGAP.GGPGG.MlaP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.12|      10|     183|     556|     565|       3
---------------------------------------------------------------------------
  556-  565 (20.24/19.04)	DDLYS.MDDIL
  741-  751 (15.88/13.15)	DDLFSqYDDII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.87|      11|      17|     634|     644|       4
---------------------------------------------------------------------------
  634-  644 (22.65/15.22)	MYPQGQVSV.DR
  653-  664 (17.22/ 9.65)	MYDDLQSSVyDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.87|      10|      18|     343|     352|       5
---------------------------------------------------------------------------
  343-  352 (17.69/14.34)	EAAGKLETMI
  364-  373 (20.18/17.57)	EYLGNLETWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.82|      15|      17|     168|     183|       6
---------------------------------------------------------------------------
  168-  182 (30.37/ 9.49)	GMQPAGN.AQQMQQPF
  186-  201 (26.45/ 7.90)	GAPPQHAmHQQQQQHY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29206 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVPPALQPSPFHPPTGGAAGGGGQSGPGSAGRPAIPPDPQPTQAAARAAAAAAAAGGGAGAASVMAPPLGQPPPQMGSGAVSAGGGALSAAPPGGGSASMDDAMGGMQPAGNAQQMQQPFNPYGAPPQHAMHQQQQQHYQLQQQQHQQQAAAAAARSKAAAAAAAQMRAASAQPPPQQQPMHYGGMPGGAAPPPHNPYAQNPYGQMQPQPQHGYGGMGMGPGAPVDMGGVGGGSAGGGAAL
2) RQWYLAQPPQGGSGAPGPSYGGGPPGGPAPGGGGGGTPMDSNNYDDL
3) SPANMHGAHGTGGAGGMGGPPSGGGPMSEALSASMMLDQGQGPPPGMGGYGMPHPYGMQPQPQPQQHHMMGGWGMHPQMGMAGPGAGTGPQPHHLMMPPQQQHVGGGPMHAHAPYRGADAAEMSRPYPSAHMRPMPGHHTMGGGPPGMHMGAPGGPGGMLAPGQPPGVGGSGLDDLYSMDDILPTPSLEGGTQGASGAKPRLAEA
63
697
383
303
743
587










Molecular Recognition Features






MoRF SequenceStartStop




1) GGGGGTPMDSNNYDDLFSQYDDIIN
2) RAAAAAA
728
109
752
115