<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29183

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSARNVNFNPSKISSNFSSIIAEKLRYNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQFPNQGCSSPPPAMPSDVDTAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRFLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSMGPGAGGHPGHSILAQQGNALPPTPTSQPSGGSQPQTPFTDFYICPQHRPIVYGLSCMLQSIVLCCPSALVWHYSLTDCRNKTGSPLDLLPIAPSSLPMPGGNTALTQQVRTKLREIEEQVKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFEKSDFNNSLDLLYNRIFGSGQSKDSHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSVSSGSLSAATVPVFQDVLLQFLDTQAPTLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKDQEAGSNCKNEDTGLSESMEIDHNSSANFDEVQRDDNFSFADMFSPPMHCESKGSPSPEKPPPEQDSKAGSKDKGMDPAFPQLYDQPRHIQYATHFPIPQEESSSHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETEKTVYFFFIKPRPFPSTGGEEGQKRKKSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSNLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYNSCSHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPVFMVEAIANPSAHNFNHSMVGKILNDSKANRYSFVCNVLMDVCVDHRDPERVSDIGILCAELTAYCRYLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVKSGPVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHTSGLDDISEGGNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSSNPSGNGAVGSGGSTSNNNSTASKMKPILSSSERSGVWLVAPLIAKLSTAVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQLQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTIRVDRKVNKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPMSQEPEKKMMEAVKPEKSVPGVPSDSNKKKPSKKKKNSSNKTEDGVNRAPGGVSYGTNMPPELMQNHPYGRLPYGQQAMNMYTQNQPLPPDKGGPGLEPPYRPARNPQMNKMMPVRPNYTSMMSGMQGNMPGIMGLDKQYPMGFKPQPNMPQGQIRQQLQVQNQSLIGQQIRQMTPNQPYTPMQASQGYTTFGSHMGMQQHLSQGGGMAPSSYGSQNFQGTHPANNPAVVDPHRQLQQRPSGYVHQQAPGYPHNMQNTQRFPHQPIQQNPIMHGLGHMGGQGVHPSMRPNQMLPQTTSTKTQQQQVQPQQVPPQQQVARRQY
Length2080
PositionKinase
OrganismTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Tetraodon.
Aromaticity0.07
Grand average of hydropathy-0.487
Instability index52.50
Isoelectric point6.80
Molecular weight232850.17
Publications
PubMed=15496914

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29183
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     183.48|      36|      38|    1865|    1900|       1
---------------------------------------------------------------------------
 1852- 1883 (39.37/17.68)	..G..P.....GLEPPYR.parnPQMNKMMPVRP.NYTSMMSG
 1884- 1908 (29.29/10.94)	MQG..NMPGIMGLDKQYPM.gfkPQPNM...............
 1909- 1944 (44.99/21.44)	PQG..QIRQQLQVQNQSLI...gQQIRQMTPNQP..YTPMQAS
 1945- 1979 (31.17/12.19)	.QGytTFGSHMGMQQH......lSQGGGMAPSSY.GSQNFQGT
 2002- 2032 (38.66/17.20)	VHQ..QAPG.......YPH...nMQNTQRFPHQPiQQNPIMHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      14|      15|    1668|    1682|       2
---------------------------------------------------------------------------
 1668- 1682 (20.41/13.17)	TKgNKIAGFEK.EGLQ
 1685- 1699 (22.26/ 9.73)	TK.QKISPWDVfEGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.09|      15|      15|     863|     877|       3
---------------------------------------------------------------------------
  863-  877 (26.84/15.46)	LEQITSFALG.MSYHL
  879-  894 (23.25/12.47)	LVQHIQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.17|      11|     112|    1012|    1022|       4
---------------------------------------------------------------------------
 1012- 1022 (23.01/15.75)	NSIYCNIDPSD
 1121- 1131 (21.17/13.80)	NDLLCNVDVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.61|      40|     112|     695|     738|       5
---------------------------------------------------------------------------
  638-  677 (67.75/32.82)	PRSPSDEPSDESERKDQEAGSNCKNEDTGLSESMEIDHNS
  699-  738 (71.86/40.49)	PMHCESKGSPSPEKPPPEQDSKAGSKDKGMDPAFPQLYDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.90|      11|      97|    1742|    1752|       7
---------------------------------------------------------------------------
 1742- 1752 (22.14/11.23)	YLEPLPLPPEE
 1840- 1850 (22.76/11.80)	YTQNQPLPPDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.21|      24|     110|    1594|    1619|      13
---------------------------------------------------------------------------
 1570- 1593 (39.25/20.90)	LDIISSGTV..DMQSNNELFTTVLDM
 1594- 1619 (33.95/22.64)	LSVLINGTLaaDMSSISQGSMEENKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29183 with Med12 domain of Kingdom Metazoa
Unable to open file!