<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29182

Description Mediator complex subunit 14
SequenceMAPVQIGSDGQLVPLGGPVLSGPQPPPTGGGATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLSVWNQQVLGRKTGAASVYKVTIKIDESDGSKPLQISHEPPLPSCDSKLIERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKANNPSDNAFIETALPTLIIPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKSINDDMKRIISWLQQLKFWLGEQRSRQSVKHLPTVCTNVLHLSNSASHPVGSLSKHKLFVKLTRLPQYYIVVEMFEIPNSPTALQYKYSFLSVSQLEGEDGPLCAQLLQHFKPNLEQLTQDTIKGKGARPGTKRKMSGEHGDPEPKKPKRSGEMCAFNKELAHVVAMCDTNMPFIGLRTELSHMEIPNQGVQVEGDGSSHAICLLKIPPCKSVGEETRRALERSLLDCTFRLQGRNNRTWVAELVLANCPLNSTHSKEQASTRHIYLTYENPLSEPVGGRKVVEMFLNDWTAISQLYQCVLNFSRALPDMPSYLSLFSEVRLYNYRKLVLCYGATKGSSVTIQWNSSSQRFHLALGTVGPNSGCSNCHNIILHQLQELFNKSPNVMQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSATHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVDVIDSLMNQLQAPQQPQPQPMRAAAGGVYPPLTSPPPNYHANVTPSPSMMPTQSPGNIHTSGSPSGVLRAPSPFGPTPSPSSLGIAMGQTSFASPHGTGVDPSSPYAMVSPSHRGQWPGSPQFSGPSPGARIHSMSPGNPSLHSPIPDPHSPRAGTSSQIMPTSMPPPRKLPQRPWAASIPTILTHNALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEANLSIVNSNEPGVIMFKTDMLKCRVALNPKNYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVHIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRLPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQGECTIFTSVHELMANLTLPPCTRQ
Length1436
PositionTail
OrganismTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Tetraodon.
Aromaticity0.06
Grand average of hydropathy-0.192
Instability index52.71
Isoelectric point8.72
Molecular weight159287.25
Publications
PubMed=15496914

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
blood vessel morphogenesis	GO:0048514	IEA:Ensembl
embryonic viscerocranium morphogenesis	GO:0048703	IEA:Ensembl
neural crest cell differentiation	GO:0014033	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl
ventricular system development	GO:0021591	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29182
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     294.36|      76|      79|     980|    1057|       1
---------------------------------------------------------------------------
  980- 1057 (139.18/66.83)	SLM..N.QLQAPqQPQPQPMRAAAGGVYPPLTSPPPNYHANVTP.SPSMMPTQSPGN.IHTSGSPSgVLRAPSP.F.GPTPSPSS
 1064- 1107 (50.75/17.19)	..............................QTSFASPHGTGVDPsSPYAM..VSPS...HRGQWPG......SPqFsGPSPGARI
 1109- 1178 (104.43/43.59)	SMSpgNpSLHSP.IPDPHSPRAGTSSQIMPTSMPPPRKLPQ.RP.WAASIPTILTHNaLH.......VLLLPSP...TPCLVP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.84|      43|      78|     384|     430|       2
---------------------------------------------------------------------------
  384-  430 (60.14/48.45)	VEKLLIDSVHaRSHQKLQELKAILKANNPSDNAfieTALPTLIIPIL
  465-  507 (75.71/47.62)	IEKSINDDMK.RIISWLQQLKFWLGEQRSRQSV...KHLPTVCTNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.95|      70|     508|     729|     889|       3
---------------------------------------------------------------------------
  809-  889 (107.18/193.70)	IQWNSssqRFHLALGTVGPNSGCSNCHNIILHQlQELFnkspnVMQLLQVLYDTQAPLNAInkLPTV.PM.LGLTQRTNTAYQ
 1315- 1386 (117.77/46.39)	LKWNV...QFCLTIPPSAPPIAPPGTIAVVLKS.KMLF.....FLQLTQRLPVPQDPVSII..VPIVyDMaTGLTQQADIPRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.73|      46|      73|     575|     624|       4
---------------------------------------------------------------------------
  575-  624 (75.51/64.02)	LQHFK.PNleQLTQdtIKGKGARPG...TKRKMSGEHGDPEPKKPKRSGEMCAF
  648-  697 (72.22/48.44)	LSHMEiPN..QGVQ..VEGDGSSHAiclLKIPPCKSVGEETRRALERSLLDCTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     206.83|      58|      73|      98|     157|       5
---------------------------------------------------------------------------
   98-  157 (91.56/76.64)	KVEKCAMISSFLDQ...QTILFVDTADRLASLarDALVHAR..............LPSFAI..PFAIDVLTTGSYPRLP
  172-  231 (77.17/57.18)	KSEKQTTLNQ.LNQilrHRLVTTDLPPQLANL...TVANGR..............V.KFRVegEFEATLTVMGDDPDIP
  246-  295 (38.10/23.51)	TGDGRALVHSL..Q...VNFI.............HELVQARlcadekplqdmyncLHSFCL..SLQLEVL.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.36|      29|     210|     538|     569|       6
---------------------------------------------------------------------------
  538-  569 (44.13/41.47)	VVEMFEipNSPTALQYKYS.FLSVSQlEGEDGP
  749-  778 (50.24/33.98)	VVEMFL..NDWTAISQLYQcVLNFSR.ALPDMP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29182 with Med14 domain of Kingdom Metazoa
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