<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29180

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTEMFSTLFGQNEAQGPPGSSSLGFGPSKPPPPLPQSQVALAAQMPPQHGDEGPALRKPGAMNEPFYLLRELPVGNELTGNTNLITHYNLEHAYNKFCGKKVKEKLSNFLPELPGMIDCPGTQDGSSLRSLIDKPPVCGNSFSPLTGALLTGFRLHTGPVLLLPEQYRLMHIQPPKKKSKHKHKHHRPQDPLPQETPSDTDPKKKKKKRDDDPDHEPSHVVCVRPQNRHSPDHPGLAGSQPNSSSSLR
Length248
PositionHead
OrganismTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Tetraodon.
Aromaticity0.05
Grand average of hydropathy-0.855
Instability index59.09
Isoelectric point9.11
Molecular weight27228.64
Publications
PubMed=15496914

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29180
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.19|      16|      19|     181|     198|       1
---------------------------------------------------------------------------
  181-  198 (28.29/18.62)	HKHKHHRPQDplPQETPS
  203-  218 (29.90/13.61)	KKKKKKRDDD..PDHEPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.44|      17|      26|      14|      36|       2
---------------------------------------------------------------------------
   14-   32 (30.04/17.24)	AQGPPGSSSlgFGPSKPPP
   43-   59 (34.40/ 8.12)	AQMPPQHGD..EGPALRKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.74|      18|      21|      98|     115|       3
---------------------------------------------------------------------------
   98-  115 (32.08/18.23)	C.GKKVKEKLSNFL..PELPG
  119-  139 (24.66/12.47)	CpGTQDGSSLRSLIdkPPVCG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29180 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MFSTLFGQNEAQGPPGSSSLGFGPSKPPPPLPQSQVALAAQMPPQHGDEGPALRKPG
2) PEQYRLMHIQPPKKKSKHKHKHHRPQDPLPQETPSDTDPKKKKKKRDDDPDHEPSHVVCVRPQNRHSPDHPGLAGSQPNSSSSLR
4
164
60
248










Molecular Recognition Features






MoRF SequenceStartStop




1) PKKKKKKRDD
2) YRLMHI
202
167
211
172