<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29177

Description Mediator of RNA polymerase II transcription subunit 13
SequenceKIPEECVYRPSWTMGRELLNPVPVMTFLNKDSNIPSVGSAMDQDYTQTYTPQTHTPFMSNSAPPSNSGTGILPSPATPRFSAPTPRTPRTPRTPRGPSSVQGSLKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYLSDPIGEAQEPCSCGFSSVVNRRYGNGCGLFLEDELDIIGRGSDISREAEKRFEELRSSSLERAGAGRSEHVPDEIILLLQDQCTIPFSPILSLEQDPVARGPHGALVPPCVRVEERDYCSDCYMALEHGRQFMDNMSGGKVDEALVKSTCLHKWTKQNAVDVSALCSQDVLHVLLSLQPLLQDAIQKKKTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDIGYLVVCPDSEALLGNAKSFFRDLTAVYESCRLGPAPAHFQRAHPDGMVLVGTQRCQDPHGDQPVSDWFLKAAGTNSDAFTRLKLYAQVCRHNLAPYLASQALDSSLLTQPTSRRPHKRLAPPPASRAQGTQEAPPFPAAAPAVPVNGSASSGSLMTSAGQPGSGMPSSKPTTFPPFGSMSAQAQAGAPQSGQLGQQASTQNTSSSGDSSSSQAPGPTEPPESTLEREKVGVPTDGESHAIAYPPAIVVYIVDPFSYDEANGAAGPVPTHSSVWTLGLRCYLEMLQFLPPHIRNIISVQIVPCQYLLQPVRGDDRHIYAQHLKSLAFSVYAQCRRPLPTTTNVKSLTGFGPGLAIDTALRVPERSECLRLYTPPFILAPVKDKQTELGEFGEASQKYNVLFVGYCLSHDQRWLLATCTDLYGELLETGIINIDVPNRARRKKGSARRLGLQKLWDWCLGLVQMTSVPWRVVIGRLGRIGHGELKDWSILLSRRNLQSLSRRLKEMCRMCGISASDTPSILSVCLVAMEPQGSFFIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSAFVQVASSSYTNIDTNIDILNATTVTDGSDAIGIFDLLDQENELVDPDIINISPTTSPVHSPGSHYHHGGDGIKGQSTDRMESHEEVPNLLQQPLALGYLVSTVKAGPLPDWFWSACPQAQNQCPLFLKASLHLHSSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length1222
PositionMiddle
OrganismTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Tetraodon.
Aromaticity0.07
Grand average of hydropathy-0.251
Instability index55.69
Isoelectric point5.83
Molecular weight133603.91
Publications
PubMed=15496914

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29177
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.47|      15|      20|     440|     458|       1
---------------------------------------------------------------------------
  440-  458 (17.63/19.41)	RDigyLVVCPDSeALLGNA
  463-  477 (26.84/13.00)	RD...LTAVYES.CRLGPA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.07|      50|     230|      15|      64|       2
---------------------------------------------------------------------------
   15-   64 (87.80/49.87)	GRELLNPVPVMTFLNKDSNIP.SVGSAMDQDYTQTYTPQTHTPFMSNSAPP
  211-  246 (37.67/17.19)	............FLEDELDII.GRGSDISREAEKRFEELRSSSLERAGA..
  247-  290 (68.61/37.36)	GRSEHVPDEIILLLQDQCTIPfSPILSLEQD......PVARGP.HGALVPP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.29|      19|      21|     367|     386|       3
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  360-  378 (31.82/13.65)	PLLQDAIQKKKTVRSWGVQ
  380-  398 (36.47/21.82)	PLTWQQFHKMAGRGSYGTD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     367.88|      86|     244|     480|     565|       4
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  480-  565 (154.25/73.43)	HFQRAHPDGMVLVGTQRCQDPHGDQPV..SDWFLKAAGTNSDAFTRLKLYAQVCRHNLAPYLASQALDS...SLLTQPTSRRPHK....RLAPPP
  618-  686 (97.03/43.63)	............FGSMSAQAQAG.APQ..SGQLGQQASTQNTSSSGDSSSSQAPGPTEPP...ESTLER...EKVGVPTDGESHA.....IAYPP
  727-  815 (116.60/53.82)	QFLPPHIRNIISVQIVPCQ..YLLQPVrgDDRHIYAQHLKSLAFS...VYAQ.CRRPLPTTTNVKSLTGfgpGLAIDTALRVPERseclRLYTPP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.06|      30|     512|     179|     210|       5
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  179-  210 (53.71/35.67)	VYLSDPIGEAQEPCSCG....FSSVVNrrYGNGCGL
  690-  723 (51.36/28.14)	VYIVDPFSYDEANGAAGpvptHSSVWT..LGLRCYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.27|      13|      15|      97|     109|       6
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   97-  109 (22.60/10.45)	PSSVQGSLKYENS
  114-  126 (24.67/12.09)	PASTPSTCRPLNS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.24|      12|      18|     322|     333|       7
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  322-  333 (21.60/13.71)	VD.EALVKSTCLH
  341-  353 (17.64/ 9.83)	VDvSALCSQDVLH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     230.71|      68|     199|     860|     927|       8
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  860-  927 (121.71/68.10)	DLYGELLETGIINIDVPNRARRKKGSARRLGLQKLWDWCLG.LVQMTSVP....WRVVIGRL.GRIGHGELKDW
 1056- 1129 (109.00/60.23)	DQENELVDPDIINISPTTSPVHSPGSHYHHGGDGIKGQSTDrMESHEEVPnllqQPLALGYLvSTVKAGPLPDW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29177 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIINISPTTSPVHSPGSHYHHGGDGIKGQSTDRMESHEEV
2) LNPVPVMTFLNKDSNIPSVGSAMDQDYTQTYTPQTHTPFMSNSAPPSNSGTGILPSPATPRFSAPTPRTPRTPRTPRGPSSVQGSLKYENS
3) SSLLTQPTSRRPHKRLAPPPASRAQGTQEAPPFPAAAPAVPVNGSASSGSLMTSAGQPGSGMPSSKPTTFPPFGSMSAQAQAGAPQSGQLGQQASTQNTSSSGDSSSSQAPGPTEPPESTLEREKVGVPTDGE
1065
19
546
1104
109
678










Molecular Recognition Features






MoRF SequenceStartStop




NANANA