<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29168

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSGGPAVRISIESVCEKQVQEVALDGTETYVPPLSMSQNLSKLAQRIDFSQGSDSEEVEGEGELREREWSKQEQEEEDDSKGTVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSVVKEKKYMALDPVSQDQTGRAQTPQVFQLLSKKKSLATAGQLLLKGAEKLSKSVAENLENQRQRDFNSELLRLRSQWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKVPEDYCPLDVQIPSDLEGSAYIKVSIQKQAHDIGDLGAFNLFRRPGHLSSPRSATVAGTQAWHMKLEAAQNVLFCKEIFAQLSREAVQIKSQIPHIVVKNQIISQLFPGLQLSISLCHSANEKKHQRVSPEKPKADDCLYVLEHNLHQMMREFHKQQLSSVVMPHPASAPFGHKRLRLAGPLAYDKTEISNLQHSEGLLEKIIKQAKHIFLRSRTARTIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVVTLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAITVASPNGENAISVRNGPESGCRVLIQFPRSQSKELPKNDVVQDAKWSHLRGPSKEVHWSRMEGRNFVYKMELLMAAMTPCP
Length654
PositionHead
OrganismTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Tetraodon.
Aromaticity0.06
Grand average of hydropathy-0.456
Instability index51.71
Isoelectric point7.68
Molecular weight73544.91
Publications
PubMed=15496914

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29168
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.86|      37|     129|      24|      65|       1
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   24-   65 (48.81/49.97)	LDGTETYVPplSMSQNLSKLAQRiDFSqgSDSEEVEGEGELR
  159-  195 (62.05/41.58)	LKGAEKLSK..SVAENLENQRQR.DFN..SELLRLRSQWKLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     379.83|     124|     161|     343|     476|       3
---------------------------------------------------------------------------
  343-  476 (200.17/126.40)	LQLSIS.....LCHsanekKHQRV...SPEKPKADDCLyvL....EHNLH...QMMR..EFHKQQLSSVVMPHPASAPFGHKRLRLAGPLAYDKTEISNLQHS..EGLLEKIIKQAKHIflrSRTARTIDSLASRIEDPQIQAHWSNI...NDVYE
  497-  642 (179.67/95.40)	LQLNIGveqirVVH.....RDGRVvtlSHQEQELQDFL..LsqmsQHQVHavqQLAKvmGWHVLSFSNHVGLGPVESIGNASAITVASPNGENAISVRNGPESgcRVLIQFPRSQSKEL...PKNDVVQDAKWSHLRGPSKEVHWSRMegrNFVYK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29168 with Med17 domain of Kingdom Metazoa
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