<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29152

Description Mediator complex subunit 12
SequenceSIVLCCPSALVWHYSLTDCRNKTGSPLDLLPIAPSSLPMPGGNTALTQQVRTKLREIEEQVKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFEKSDFNNSLDLLYNRIFGSGQSKDSHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSVSSGSLSAATVPVFQDVLLQFLDTQAPTLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKDQEAGSNCKNEDTGLSESMEIDHNSSANFDEMFSPPMHCESKGSPSPEKPPPEQDSKAGSKDKGMDPAFPQLYDQPRHIQYATHFPIPQEESSSHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGKQVSITPSTFHPTNLSHTGGEEGQKRKKSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSNLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYNSCSHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPVFMVEAIANPSAHNFNHSMVGKILNDSKANRYSFVCNVLMDVCVDHRDPERVSDIGILCAELTAYCRYLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVKSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHTSGLDDISEGGNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSSNPSGNGAVGSGGSTSNNNSTASKMKPILSSSERSGVWLVAPLIAKLSTAVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQLQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTIRVDRKVNKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPMSQEPEKKMMEAVKPEKSVPGVPSDSNKKKPSKKKKNSSNKTEDGVNRAPGGVSYGTNMPPELMQNHPYGRLPYGQQAMNMYTQNQPLPPGGPGLEPPYRPARNPQMNKMMPVRPNYTSMMSGMQGNMPGIMGLDKQYPMGFKPQPNMPQGQIRQQLQVRLNQSLIGQQIRQMTPNQPYTPMQASQGYTTFGSHMGMQQHLSQGGGMAPSSYGSQNFQGTHPANNPAVVDPHRQLQQRPSGYVHQQAPGYPHNMQNTQRFPHQPIQQNPIMHGLGHMGGQGVHPSMRPNQMLAEQQQQQQQQQQAAQQQQQYLRQQALRQQQQQQQQQQQQQQVQPQQVPPQQQVQQQQQQQQQQVSAVPPPGQAQNQGLGMQPLPPQQPMGMQQTQQQQQTAALVRQLQQQLSSKSLSTCQRLRLPPNLAFTNTTSLFFADSQPGQGTGSYF
Length1818
PositionKinase
OrganismTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Tetraodon.
Aromaticity0.06
Grand average of hydropathy-0.540
Instability index55.36
Isoelectric point6.50
Molecular weight202815.48
Publications
PubMed=15496914

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29152
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     267.11|      22|      22|    1695|    1716|       1
---------------------------------------------------------------------------
 1519- 1541 (26.44/ 8.59)	P......QPNMPQGQI..RQQ...........LQVrLNQSLI
 1542- 1563 (28.99/10.24)	G......QQIRQMTPN..QPY...........TPM.QASQGY
 1611- 1630 (23.49/ 6.69)	........QQRPSGYV..HQQ...........APG.YPHNMQ
 1631- 1663 (27.23/ 9.10)	N......TQRFPHQPI..QQNpimhglghmggQGV.HPSMRP
 1664- 1693 (26.89/ 8.88)	NqmlaeqQQQQQQQQQaaQQQ...........QQY.LRQQAL
 1694- 1715 (44.07/19.95)	R......QQQQQQQQQ..QQQ...........QQV.QPQQVP
 1716- 1735 (37.99/16.04)	P......QQQVQQQQQ..QQQ...........QQV.SA..VP
 1736- 1751 (26.52/ 8.64)	P..........PGQAQ..NQG...........LGM.QP..LP
 1752- 1769 (25.49/ 7.97)	P......QQPMGMQQT..QQQ...........QQT.AA....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.05|      12|      15|     502|     513|       2
---------------------------------------------------------------------------
  502-  513 (23.40/16.98)	IQFIFDLM.EYSL
  519-  531 (14.65/ 7.50)	IDFAIQLLnELSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.78|      15|      15|     292|     306|       3
---------------------------------------------------------------------------
  292-  306 (24.73/12.65)	DTGLSESMEIDHNSS
  310-  324 (28.05/15.36)	DEMFSPPMHCESKGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.04|      18|      20|    1426|    1443|       4
---------------------------------------------------------------------------
 1426- 1443 (36.80/17.88)	GGVSYGTNMPP..ELMQNHP
 1445- 1462 (30.89/13.77)	GRLPYGQQAMN..MYTQNQP
 1497- 1514 (24.35/ 9.23)	SGMQ.G.NMPGimGLDKQYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.29|      16|      20|    1367|    1383|       5
---------------------------------------------------------------------------
 1367- 1383 (25.25/17.23)	PEEEEPLTPmSQEPEKK
 1390- 1405 (29.04/14.99)	PEKSVPGVP.SDSNKKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.98|      33|     101|     325|     372|       6
---------------------------------------------------------------------------
  339-  371 (64.25/51.06)	GSKDKGMDP.AFPQLYDQPRHIQYATHFPIPQEE
  441-  474 (55.73/22.53)	GQKRKKSKPeAFPTAEDIFSKFQHLSHFDQHQVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.07|      10|      15|    1285|    1299|       7
---------------------------------------------------------------------------
 1285- 1295 (13.68/ 6.90)	TKgNKIAGFEK
 1302- 1311 (18.40/15.04)	TK.QKISPWDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.92|      16|      20|    1172|    1191|       8
---------------------------------------------------------------------------
 1172- 1191 (16.32/30.34)	VQRSTQQTTewAVllLDIIS
 1197- 1212 (27.59/22.42)	MQSNNELFT..TV..LDMLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.97|      12|      15|     651|     662|       9
---------------------------------------------------------------------------
  651-  662 (22.31/14.57)	MVEAIANPSAHN
  667-  678 (20.66/12.88)	MVGKILNDSKAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.47|      36|     108|     606|     641|      10
---------------------------------------------------------------------------
  562-  592 (38.18/22.83)	..YHSCLILNpEQTAQVFDGLRIVVK......SGV....NPAD
  606-  641 (65.25/44.71)	DLYNSCSHLK.NKFGEIFSEFCSKVK......NSIYCNIDPSD
  709-  750 (54.04/35.65)	ELTAYCRYLS.AEWLGILKALCCSSNngncgfNDLLCNVDVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.06|      17|     108|    1463|    1481|      11
---------------------------------------------------------------------------
 1463- 1480 (31.64/16.15)	LPPGGpGLEPP.Y........RPARNP
 1576- 1601 (23.42/10.00)	LSQGG.GMAPSsYgsqnfqgtHPANNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.24|      15|      15|     860|     874|      16
---------------------------------------------------------------------------
  860-  874 (24.64/16.57)	DAELRGSGLSHTSGL
  876-  890 (23.60/15.50)	DISEGGNVSIETASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.10|      13|      17|     757|     769|      17
---------------------------------------------------------------------------
  757-  769 (22.70/18.52)	LATFVAI..LIARQC
  775-  789 (18.40/13.39)	LVRCVAIpsLLNAAC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29152 with Med12 domain of Kingdom Metazoa
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