<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29131

Description Mediator of RNA polymerase II transcription subunit 15
SequenceEDAMRKAGTAHNKSGKDMENHVFMKAKSRDEYLSLVARLIIHFRDIREDKKSQAAVADPMNALQNLTGGAPPGAGPIGMGSRPPAPMGGMSSLGQMGQQMALQGQPGAGGMPSHGMQGVTAAQQTQLQMQQAVLQQQQFQAQQQQQAVLQEQQQQQFQAQQQQTAMQQQQQQLQAQQQAAAVQQQQLQAVQQQQQLLKIQMQQQQQQSQQQPQQQQRIVQMQQLQQLQQQQQQQQAVAAAAAQAMQPQQQLLRQQQQSMQQQMQQQQSQVQAQQAQLPPHSQQQTLVQQQQVMAGLNQQLKMHQAMHMRAQLVQQQQQVQQQQQQQQQQQQQQQQQQQQQQQPAAAAAAAVQQAAAQLGAAGGQIRQRFPPTSSVSAAPPVSTPSGGQQVPQANQSTVSMMSSPSPVQQAQTPQSMPPPPQPSPQPGQPTSQPNSVSSGPAPSPSSFLPSPSPQPSQSPATARTPQNFSVPSPLSTPGNPSSVMSPASSNQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLRNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGSPIAAPMVTPRKRKHEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKSLPNVPPLQLSVPSDYPDQSPQWIDNSQHYEANPFLQTVHRNMTSKMLQLPDKHSVTALLNTWAQSVRLACLSAA
Length753
PositionTail
OrganismLatimeria chalumnae (Coelacanth)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Coelacanthiformes> Coelacanthidae> Latimeria.
Aromaticity0.03
Grand average of hydropathy-0.831
Instability index88.60
Isoelectric point9.63
Molecular weight83100.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29131
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.47|      31|      31|     227|     257|       1
---------------------------------------------------------------------------
  155-  178 (45.07/ 7.66)	QQFQ.AQQQQT.......AMQQ..QQQQLQAQQQ
  227-  257 (60.29/13.47)	LQQQ.QQQQQAVAAAAAQAMQP..QQQLLRQQQQ
  259-  291 (45.11/ 7.68)	MQQQmQQQQSQVQAQQAQ.LPPhsQQQTLVQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.08|      13|      17|     314|     326|       2
---------------------------------------------------------------------------
  314-  326 (30.22/ 6.87)	QQQQQVQQQQQQQ
  330-  342 (28.87/ 6.14)	QQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.53|      24|      26|     404|     428|       3
---------------------------------------------------------------------------
  407-  435 (44.50/17.34)	VQQAQTPQSMPPPPQPSPQPGQptsqpNS
  436-  459 (40.03/12.99)	VSSGPAPSPSSFLPSPSPQPSQ.....SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.78|      28|      28|      78|     105|       4
---------------------------------------------------------------------------
   78-  105 (52.00/18.17)	GMGSRPPAPMGGMSSLG....QMGQQMALQGQ
  107-  137 (44.57/14.14)	GAGGMPSHGMQGVTAAQqtqlQM.QQAVLQQQ
  195-  216 (38.21/10.69)	Q...LLKIQMQ...QQQ....QQSQQQPQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.30|      40|     136|     460|     503|       5
---------------------------------------------------------------------------
  361-  406 (60.58/25.39)	AGGQIRQRFpptsSVSaaPPVSTPSGGQQV..P.QANQS.TVSMMSSPSP
  460-  503 (56.72/34.70)	ATARTPQNF....SVP..SPLSTPGNPSSVmsPaSSNQSeEQQYLEKLKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.23|      27|      28|     528|     554|       6
---------------------------------------------------------------------------
  510-  545 (39.26/20.84)	PLRRMinkidknedRKKD..LSKMKSLLDILTDPSKRC
  546-  574 (43.97/24.18)	PLKTL.........QKCEiaLEKLRNDMAVPTPPPPPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.38|      18|     133|     579|     596|      10
---------------------------------------------------------------------------
  579-  596 (32.12/20.31)	QQYLCQPLLDAVLANIRS
  706-  723 (34.27/22.19)	QHYEANPFLQTVHRNMTS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29131 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQQQQQQQQQQQQQQQPAAAAAAAVQQAAAQLGAAGGQIRQRFPPTSSVSAAPPVSTPSGGQQVPQANQSTVSMMSSPSPVQQAQTPQSMPPPPQPSPQPGQPTSQPNSVSSGPAPSPSSFLPSPSPQPSQSPATARTPQNFSVPSPLSTPGNPSSVMSPASSNQSEEQQYLEKLKQ
2) REDKKSQAAVADPMNALQNLTGGAPPGAGPIGMGSRPPAPMGGMSSLGQMGQQMALQGQPGAGGMPSHGMQGVTAA
324
47
503
122










Molecular Recognition Features






MoRF SequenceStartStop




NANANA