Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MYLALQSLELDLSKMAYMFWQATNASTLEKILHGSVGYLTLRSGGHLMNLKYYLSPYDLFDEETGIQINMGDNNVPRSLGMNVSVTIEGTTAMSKLPIAPLIMGSHPVDSKGTPSFSSVTNTNSVDLPACFFLKFPRPIPVSRSFIQRIQNCTGISLFDTAPPFVPLYELITQFELSKDSDSVPLNHNMRFYASLPGQQHCYFLNKDAPLPDGRCLQGTLLSKIPFRHPGQVPPVLDLIRHQVAYNTLIGSCVKRTVLKEDSPGLLQFEVCPLTDACFSVSFQHPVNDSLVCVVMDVQDSRQVSCKLYKGLSDALICTDEFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMGTGNVSGTTTPTSTFSGPITTLFSMGMKERHESVGHGEDFSKVSQNPILTSLLQITGNVGSTVGSSPTPPHHTPPPVSSPASNTKSHPMLMNLLKDNPTQDFSTLYGSSPLEKQNSASGSPRTDMGTGAPKQKKKRPRPGTDKPKHQTEDDFQKELISMDVDSQNTIFDVNMNADTLDTHITPATSQCNTPPIAYQQPIAYPQSSMPRMVRLSSSDSIGPDVTDILSDIAEQASKLPSTSDDCPPLGTPVRESSNSSTLFDPDVFQAGSNENPYTDPADLLADATHTPNSDSSNPLFPEGVDFNPDLLGSHSQSDFPYFDDSSHSGDAEDLKGFPSQALSSMGVQVMGSDGGENSFKGSSQTETVDFGAFPSAGKSLGSSDITEHSIGDQSPLMSTEDLGKDKSQKPRSKDGNGSGSSNMSGMGLDGKPGKRSRTPSSEGKSKEKPQKRKKTDPEGKSPSHSASSRPFTPPASTGGSKSPGSLGRSQTPPGGATPPIPKITIQIPKGTLTVGKPSSHSGQYTSSSSGSSSSSKSHHSHSSSSSTSSSSSTSSSSSGKVKSSKSDSSSSSKMSSGLYSGQSSSSSGQSKGSSQSMGKPGSSPITKHGLSSSSSGSKIKPQGKPSSSLMNPSLSKPNISPSHSRPSSGADKLSSPMKPVPGTPPSSKAKSPISSGSGSSHMSGSGSGSSMKTSSGMVSSGSLSQKTPPSSSSSTFSSSASSMSSSQNSHGSSKGKSPSRNKKPSLTAVIDKLKHGVGSVGPGGEDNGDGQMGVGSAPSGHSMPSKHSMSGGDFQGKREKSDKDKSKVSVSGGSGDPSSKKSSDSKNVGSTGVAKIIISKPDGGSPSIKAKVTLQKPGDGSGDGLRPQIPGSKSYGSPLFSGSTPKHERCSPSHSKSPAYTPQNVDSESESGSSVAEKSHQNSPSSEDDIRPLPEYSSEKHKKHKKEKKKAKDKDRDRDRDREKDREKKKSHSMKSESWSKSPISTDQSLSMTTSAMLSADRPSRASPGFLIGEDDDLMDVALIGN |
Length | 1401 |
Position | Middle |
Organism | Latimeria chalumnae (Coelacanth) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Coelacanthiformes> Coelacanthidae> Latimeria. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.682 |
Instability index | 55.59 |
Isoelectric point | 8.84 |
Molecular weight | 147446.07 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP29126 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 1087.41| 167| 167| 917| 1083| 2 --------------------------------------------------------------------------- 372- 494 (121.73/26.91) ...................................................................SS.PGYGMGTGNVS..........GTTTP.TSTfsgPIT....TLFSMGMKERHE.........svghGEDFSKVsQNPILT....SLLQITGNVGSTVGSS..P......TPPHHTPPPVS...SPASNTK.SHP.........MLMNLLKDNPTQDF.STLYGS....SP..LEKQNS 503- 693 (171.89/42.12) MGTGAP.KQKKKRPRPGTDKPKHQTEDDFQKELISM......DVDSQNtifdvnmnadtldthitpaTS.QCNTPPIAYQQ..........PIAYP.QSS...MPRMVRLSSSDS...IGPDvtdilsdiaeqasKLPSTSD.DCPPLGTP......VRESSNSSTLFD..PdvfqagSNENPYTDPA.......DLLA.DAT.........HTPNSDSSNPL.FP.EGVDFNpdllGS..HSQSD. 697- 802 (106.67/22.35) ........FDDSSHSGDAEDLKGFPSQALSS..M........GVQVMG...................SD.GGENSFKGSSQtetvdfgafpSAGKSlGSS...DITEHSI.........................GDQ...............SPLMSTEDLGKDK.....................SQKPRSKDGNGS.GSS.........NMSGMG............................. 805- 888 (90.46/17.43) .............................................................................................GKP.G.......KRSRTPSSEGKSKEKPQ.............KRKKT.............DPEGKSPSHSAS..SR..P......F.....TPPASTGGSK.SPGSlGRS.........QTPPGGATPPIPKI.TIQIPK....GT..LT.... 917- 1083 (282.92/75.77) SSSSST.SSSSSTSSSSSGKVKSSKSDSSSSSKMSS......GLYSGQ...................SS.SSSGQSKGSSQ..........SMGKP.GSS...PITKHGLSSSSSGSKIKPQ.............GKPSSSL.MNPSLSKPNISPSHSRPSSGADKLSS..P......MKPVPGTPPSSKAKSPISSGS.GSS.........HMSGSGSGSSMKTS.SGMVSS....GS..LSQKTP 1085- 1260 (196.33/49.53) SSSSSTfSSSASSMSSSQNSHGSSKGKSPSRNKKPSltavidKLKHGV...................GSvGPGGEDNGDGQ...........MG.V.GSA...P.SGHSMPSKHSMSGGDFQ.............GKREKS...DKDKSKVSVSGGSGDPSS...KKSS..D......SKNVGSTGV...AKIIISKPD.GGSpsikakvtlQKPGDGSGDGLRPQiPGSKSY....GSplFSGSTP 1270- 1384 (117.40/25.60) SKSPAY.TPQNVDSESESGSSVAEKSHQNSPS..SE......DDIRPL...................PE.YSSEKHKKHKK..........EKKK..........AKDKDRDRDRDREKDRE.............KKKSHSM.KSESWSKSPISTDQSLSMTTSAMLSAdrP......SRASPG............................................................... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.76| 22| 37| 213| 237| 3 --------------------------------------------------------------------------- 213- 237 (37.03/30.84) GRCLQGTLLSKipfRHPG....QVPPVLD 250- 275 (35.72/20.28) GSCVKRTVLKE...DSPGllqfEVCPLTD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EKHKKHKKEKK 2) KPSLTAVIDKLKHG 3) LRPQIP 4) PGFLIGEDDD 5) PIPKITIQIPKGTLTV 6) RPLPEYS 7) SIKAKVTLQK 8) VAKIIISK | 1314 1118 1240 1383 874 1306 1222 1208 | 1324 1131 1245 1392 889 1312 1231 1215 |
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