<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29126

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMYLALQSLELDLSKMAYMFWQATNASTLEKILHGSVGYLTLRSGGHLMNLKYYLSPYDLFDEETGIQINMGDNNVPRSLGMNVSVTIEGTTAMSKLPIAPLIMGSHPVDSKGTPSFSSVTNTNSVDLPACFFLKFPRPIPVSRSFIQRIQNCTGISLFDTAPPFVPLYELITQFELSKDSDSVPLNHNMRFYASLPGQQHCYFLNKDAPLPDGRCLQGTLLSKIPFRHPGQVPPVLDLIRHQVAYNTLIGSCVKRTVLKEDSPGLLQFEVCPLTDACFSVSFQHPVNDSLVCVVMDVQDSRQVSCKLYKGLSDALICTDEFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMGTGNVSGTTTPTSTFSGPITTLFSMGMKERHESVGHGEDFSKVSQNPILTSLLQITGNVGSTVGSSPTPPHHTPPPVSSPASNTKSHPMLMNLLKDNPTQDFSTLYGSSPLEKQNSASGSPRTDMGTGAPKQKKKRPRPGTDKPKHQTEDDFQKELISMDVDSQNTIFDVNMNADTLDTHITPATSQCNTPPIAYQQPIAYPQSSMPRMVRLSSSDSIGPDVTDILSDIAEQASKLPSTSDDCPPLGTPVRESSNSSTLFDPDVFQAGSNENPYTDPADLLADATHTPNSDSSNPLFPEGVDFNPDLLGSHSQSDFPYFDDSSHSGDAEDLKGFPSQALSSMGVQVMGSDGGENSFKGSSQTETVDFGAFPSAGKSLGSSDITEHSIGDQSPLMSTEDLGKDKSQKPRSKDGNGSGSSNMSGMGLDGKPGKRSRTPSSEGKSKEKPQKRKKTDPEGKSPSHSASSRPFTPPASTGGSKSPGSLGRSQTPPGGATPPIPKITIQIPKGTLTVGKPSSHSGQYTSSSSGSSSSSKSHHSHSSSSSTSSSSSTSSSSSGKVKSSKSDSSSSSKMSSGLYSGQSSSSSGQSKGSSQSMGKPGSSPITKHGLSSSSSGSKIKPQGKPSSSLMNPSLSKPNISPSHSRPSSGADKLSSPMKPVPGTPPSSKAKSPISSGSGSSHMSGSGSGSSMKTSSGMVSSGSLSQKTPPSSSSSTFSSSASSMSSSQNSHGSSKGKSPSRNKKPSLTAVIDKLKHGVGSVGPGGEDNGDGQMGVGSAPSGHSMPSKHSMSGGDFQGKREKSDKDKSKVSVSGGSGDPSSKKSSDSKNVGSTGVAKIIISKPDGGSPSIKAKVTLQKPGDGSGDGLRPQIPGSKSYGSPLFSGSTPKHERCSPSHSKSPAYTPQNVDSESESGSSVAEKSHQNSPSSEDDIRPLPEYSSEKHKKHKKEKKKAKDKDRDRDRDREKDREKKKSHSMKSESWSKSPISTDQSLSMTTSAMLSADRPSRASPGFLIGEDDDLMDVALIGN
Length1401
PositionMiddle
OrganismLatimeria chalumnae (Coelacanth)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Coelacanthiformes> Coelacanthidae> Latimeria.
Aromaticity0.04
Grand average of hydropathy-0.682
Instability index55.59
Isoelectric point8.84
Molecular weight147446.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29126
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1087.41|     167|     167|     917|    1083|       2
---------------------------------------------------------------------------
  372-  494 (121.73/26.91)	...................................................................SS.PGYGMGTGNVS..........GTTTP.TSTfsgPIT....TLFSMGMKERHE.........svghGEDFSKVsQNPILT....SLLQITGNVGSTVGSS..P......TPPHHTPPPVS...SPASNTK.SHP.........MLMNLLKDNPTQDF.STLYGS....SP..LEKQNS
  503-  693 (171.89/42.12)	MGTGAP.KQKKKRPRPGTDKPKHQTEDDFQKELISM......DVDSQNtifdvnmnadtldthitpaTS.QCNTPPIAYQQ..........PIAYP.QSS...MPRMVRLSSSDS...IGPDvtdilsdiaeqasKLPSTSD.DCPPLGTP......VRESSNSSTLFD..PdvfqagSNENPYTDPA.......DLLA.DAT.........HTPNSDSSNPL.FP.EGVDFNpdllGS..HSQSD.
  697-  802 (106.67/22.35)	........FDDSSHSGDAEDLKGFPSQALSS..M........GVQVMG...................SD.GGENSFKGSSQtetvdfgafpSAGKSlGSS...DITEHSI.........................GDQ...............SPLMSTEDLGKDK.....................SQKPRSKDGNGS.GSS.........NMSGMG.............................
  805-  888 (90.46/17.43)	.............................................................................................GKP.G.......KRSRTPSSEGKSKEKPQ.............KRKKT.............DPEGKSPSHSAS..SR..P......F.....TPPASTGGSK.SPGSlGRS.........QTPPGGATPPIPKI.TIQIPK....GT..LT....
  917- 1083 (282.92/75.77)	SSSSST.SSSSSTSSSSSGKVKSSKSDSSSSSKMSS......GLYSGQ...................SS.SSSGQSKGSSQ..........SMGKP.GSS...PITKHGLSSSSSGSKIKPQ.............GKPSSSL.MNPSLSKPNISPSHSRPSSGADKLSS..P......MKPVPGTPPSSKAKSPISSGS.GSS.........HMSGSGSGSSMKTS.SGMVSS....GS..LSQKTP
 1085- 1260 (196.33/49.53)	SSSSSTfSSSASSMSSSQNSHGSSKGKSPSRNKKPSltavidKLKHGV...................GSvGPGGEDNGDGQ...........MG.V.GSA...P.SGHSMPSKHSMSGGDFQ.............GKREKS...DKDKSKVSVSGGSGDPSS...KKSS..D......SKNVGSTGV...AKIIISKPD.GGSpsikakvtlQKPGDGSGDGLRPQiPGSKSY....GSplFSGSTP
 1270- 1384 (117.40/25.60)	SKSPAY.TPQNVDSESESGSSVAEKSHQNSPS..SE......DDIRPL...................PE.YSSEKHKKHKK..........EKKK..........AKDKDRDRDRDREKDRE.............KKKSHSM.KSESWSKSPISTDQSLSMTTSAMLSAdrP......SRASPG...............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.76|      22|      37|     213|     237|       3
---------------------------------------------------------------------------
  213-  237 (37.03/30.84)	GRCLQGTLLSKipfRHPG....QVPPVLD
  250-  275 (35.72/20.28)	GSCVKRTVLKE...DSPGllqfEVCPLTD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29126 with Med1 domain of Kingdom Metazoa
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