<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29119
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | EYLLSCLERLQKVLSAASLPSLFNHLESVAKQKGLDTHLSPTSTACYITSDLFYLEIQIEPDGHVIDVIIAHHGETPESCEELVQLLRMKNFDDFAKSLEGLSNLYQVPGDRKIKTKVYQVLKSLEMDLNTMADMYRFRKSNADRVTTILQGPVGYFVPRNGGNPTTLEYFISPYDQLEKRLEPGTIIIFSSTAQISGMKVFVTVEGISTSCKLPITPLIQNSQQDIDRGIPTFAPLTEEVNNELPACFFLKFPEPFPMLIDLIQKIQNLTGLSVMEQSASVSFYELLAKSEMKSPIDPNKILNLFQMHVILYNLHHSYVLYMDKEKPLLGTLVSKIPFTHPMQVSSILDILRHQAAYNLLVGSCISEKRTKNAAPELHHFEVHSLNGTSFSVSFWHPFSDNLTHVVFDVLNSRQISCELHTEPAAAASLGCSEEFISRVVHYCMSIPITMRAILKKAAKIPEDCNMLTETV |
Length | 472 |
Position | Middle |
Organism | Latimeria chalumnae (Coelacanth) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Coelacanthiformes> Coelacanthidae> Latimeria.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.027 |
Instability index | 45.28 |
Isoelectric point | 5.80 |
Molecular weight | 53090.71 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP29119
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 87.26| 30| 34| 184| 215| 1
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186- 215 (51.33/35.45) TIIIFSSTAQIS.GMKVFVTV.EGIST...SC...KLP
217- 254 (35.93/16.75) TPLIQNSQQDIDrGIPTFAPLtEEVNNelpACfflKFP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.51| 15| 34| 261| 276| 2
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261- 276 (21.60/18.90) IDlIQKIQNLTGLSVM
297- 311 (27.91/19.26) ID.PNKILNLFQMHVI
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