<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29111

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNHPAVSGDEHGSAKNVNFNSDKINSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTHLSKKVPIFSKKEEVFGYLAKYSVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKIAEFYRQTSNSSCGSPIPATPLEIEQTMKQWEYNEKLAMFMFQEGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLMLQYSGEFVQSSYLSRRLAYFCTRRLALLLNDGTAGSGPGGHQPHVMSAQTGNALPPTPTPQPTPGNQPQTAFTDFCICAQHRPVVYGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPITPSNLPMSGGNTAFTQQVRGRLREIEQQIKERGQAVEVRWSFDKCQETTAGGFTIGRVLHTLEVLDSHSFERSDFNNSLDSLYNRIFGLGQSKDGHEISPDDDVVVTLLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSISSGSLSAASVPVFQDVLMQFLDTQAPMLTDPSNENEKVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLVSEAHVPRPRSPFDEPGEEADRKEQEGNNSIKLEDAGLNESMDIDPNSSTMFDEVEKSDFPVFSPPMHCESKASPDPEKPDLEKDGKVTQKGKVPDVTILSLYEQPRHIQYATHFPIPQEESCSHECNQRLVVLYGVGKQRDEARHGIKKITKDILKVLNRKSTAETGGFCPLFLFLLQHPNIDLLQRGEEGQKRKRNKPEVFPTAEDIFTKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVHHVQFIFDLMEYSFNISGLIDFAIQLLNELSVVEAELLLKSSNLVGSYTTGLCLCIVAVLRRYHSCLILNPDQMAQVFDSLCGVVKHGVNPSDCSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNSIYCNIDPSDSNMLWEPEYMIETIENPSAHSFTHSALVNRLNENPAKRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTAYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQESSKSSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFNHSGGIDELAEDELGAKKPGGRAVSIETASLDIYAKYVLKSICQQEWVGERCLKSLCEDSSALQDPVLTNIQAQRLLQLICYPHRQLDSEEGDNPQRQRIKRILQNLDQWTMRQSSLELQLMIKQSITSEMNSLLENIAKATIEVFQKSAEMNSNNATANSGGTGSNSASTTIPNSISTTKSKPILSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQTVYTFRHIRAVFHCVHIQVALVYNSTFLFSQVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTIRVDRRVSKFEEQQRLLLYHTHAKPKPRSYYLEPLSVSAEEEEPPTPVAVEPEKKLAEPAKVDKTCNSSGGTEDKKKKQKKKRNQSISKSEDYGMNTSRVVPMGTGLAADLLHHQPMHPYSRVNYGQSSMGVYTQNQPLPAGGPRLDATYRPSARVPMKISNRPPYSGIMPPVMPGIGGIMSLDQQSYKQGGYRPQPPPSQGQLLRQQLVAKLQNQAMGSHRQMNPTSSYGSLQAPQGYTPYGSHLGLQQQLPQAAGMVLPTYSGQAFPGSNPALIDSVRQIQQRPSGYVHQQAPGYSHSLQNPQRFTHQPMQQAPMMSGISHMASQGMHTGMRPNQLIAEQQQQQQQQQQQQQFMRQQQLLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAAAAAAAAAAAQAAVVQPQAQPPSQPQFARQGMQQTQQQQQTAALVRQLQQQLSNTQPQQNTNLFGHY
Length2199
PositionKinase
OrganismLatimeria chalumnae (Coelacanth)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Coelacanthiformes> Coelacanthidae> Latimeria.
Aromaticity0.07
Grand average of hydropathy-0.461
Instability index54.22
Isoelectric point6.97
Molecular weight246020.47
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29111
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     127.34|      18|      18|    2091|    2108|       1
---------------------------------------------------------------------------
 2075- 2097 (27.21/ 8.13)	QQQQQQQfmRQQQllrQQQQQQQ
 2098- 2116 (33.95/11.98)	QQQQQQQ..QQQQ..qQQQQQQQ
 2117- 2134 (33.38/11.65)	QQQQQQQ..QQQQ...QQQQAAA
 2155- 2172 (32.80/11.32)	SQPQFAR..QGMQ...QTQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     197.06|      29|      29|    1990|    2018|       2
---------------------------------------------------------------------------
 1864- 1884 (27.47/ 8.54)	...QPLPA.............GGPRL...DAT................YRP..SARVP
 1893- 1920 (32.70/11.58)	YSG.IMPP.............VMPGIggIMSLD....QQS........YKQ..GGY..
 1922- 1968 (25.14/ 7.19)	..PQPPPSqgqllrqqlvaklQNQAM...GSHR....QMNptssygslQAP..QGYTP
 1969- 1987 (26.66/ 8.07)	Y......G.............SHLGL..QQQLP....Q............A..AGMVL
 1990- 2018 (55.02/24.56)	YSGQAFPG.............SNPAL..IDSVR....QIQ........QRP..SGYVH
 2021- 2050 (30.07/10.05)	APGYSHSL.............QNPQ.......RfthqPMQ........QAPmmSGISH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.05|      54|     237|     263|     316|       3
---------------------------------------------------------------------------
  263-  316 (91.87/62.87)	KIRPGEDELLKLLLPLMLQY..SGE...FVQSSYLSRRLAYFCTRRLA...LLLNDGTAGSG
  501-  562 (76.18/50.79)	EISPDDDVVVTLLCEWAVSYkrSGRhraMVVAKLLEKRQAEIEAERCGeseVVDEKGSISSG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.86|      26|      64|     328|     353|       4
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  328-  353 (52.18/31.94)	QTGNALPPTP.TPQPTPGNQPQTAFTD
  394-  420 (44.68/26.05)	KTGSPLDLLPiTPSNLPMSGGNTAFTQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.91|      22|     237|    1369|    1403|       5
---------------------------------------------------------------------------
 1347- 1368 (38.84/24.01)	RQRI....KRILQNLDQWTMR..QSSLE
 1374- 1401 (24.07/21.54)	KQSItsemNSLLENIAKATIEvfQKSAE
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.54|      14|      17|    1684|    1700|       6
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 1684- 1700 (16.85/20.71)	KIAGFDsIFkkEGLQVS
 1704- 1717 (28.68/18.69)	KISPWD.LF..EGLKHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.68|      14|      27|    1178|    1194|       7
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 1178- 1194 (22.57/21.15)	GARLTC.RillHLFKTPQ
 1208- 1222 (20.11/10.23)	GIRSSCdR...HLLAASQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.23|      19|      61|     635|     653|       8
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  635-  653 (35.31/18.32)	HV.PRPRSPFDE.PGEE.....ADRK
  673-  697 (19.50/ 6.78)	DIdPNSSTMFDE.VEKSdfpvfSPPM
  698-  717 (28.42/13.29)	HC.ESKASPDPEkPDLE.....KDGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.03|      16|      30|    1482|    1497|       9
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 1482- 1497 (27.47/17.68)	KERDRQKQKSM.SLLSQ
 1509- 1525 (23.56/13.90)	KGQDEQREGLLtSLYSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.46|      28|      30|    1288|    1316|      10
---------------------------------------------------------------------------
 1096- 1116 (28.33/11.52)	..KSLSA.EWLG..VLKALCC.....SSNNG...
 1288- 1316 (49.20/28.73)	VLKSICQQEWVGeRCLKSLCE.....DSSALQDP
 1317- 1345 (35.93/16.39)	VLTNIQAQ.....RLLQLICYphrqlDSEEGDNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.17|      11|     108|    1012|    1022|      11
---------------------------------------------------------------------------
 1012- 1022 (23.01/13.59)	NSIYCNIDPSD
 1121- 1131 (21.17/11.94)	NDLLCNVDVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.52|      13|      17|    1037|    1049|      12
---------------------------------------------------------------------------
 1037- 1049 (24.95/15.14)	ENPSAH.SFTHSAL
 1055- 1068 (20.58/11.11)	ENPAKRySFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.47|      16|      28|    1734|    1761|      15
---------------------------------------------------------------------------
 1734- 1761 (17.19/34.20)	VSKFEEQQrlllyhthakPKPRSyyLEP
 1764- 1779 (29.28/15.05)	VSAEEEEP..........PTPVA..VEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.33|      23|      37|     183|     208|      16
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  183-  208 (34.48/34.61)	PcIEWTQIITKylWEQLQKIAEFYRQ
  222-  244 (43.86/28.65)	P.LEIEQTMKQ..WEYNEKLAMFMFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.13|      18|      21|    1571|    1589|      19
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 1572- 1589 (31.08/21.00)	QQTTEWAVLLLDIIS...SGT
 1593- 1613 (26.05/11.39)	QSNNELFTTVLDMLSvliNGT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.95|      25|      28|    1628|    1652|      22
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 1628- 1652 (40.22/30.61)	ENKRAYMNLVKKLRKELGDRQSESL
 1653- 1677 (42.73/33.12)	EKVRQLLPLPKQTRDVITCEPQGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.62|      19|      27|    1526|    1544|      23
---------------------------------------------------------------------------
 1526- 1544 (34.70/22.87)	VQQTVYTFRHIRAVFHCVH
 1550- 1568 (32.92/21.32)	VYNSTFLFSQVGGMFDTVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29111 with Med12 domain of Kingdom Metazoa
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