<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29108

Description Mediator complex subunit 14
SequenceMAPVQLDSNQLVPAGAPTSAPPPPPPGTPAAAAAATPGVRLSVLIDFLLQKTYHEITVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWAGNAGKVEKCAMISSFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQITLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQAQMLIRERWGDLVKVERYLPGKCLTLSVWNQQILGRKTGSASVHKVNIKIDENDVSKPLQISHEPPLPVCDSKLMERAMKIDHLSVEKLLIDSVHSRSHQKLQELKAILKSFNPGDSSFIETALPTLVVPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQTTLDDIEKSINDDMKRIIPWLQQLKFWLGQQRCKQSVKHLPTVCTETLHLSNSASHPIGNLSKNKLFVKLTRLPQYYIVVEMFEIPGCPTQLEYKYYFLSVSQSDGDDSPPIALLLQQFKPNIEELALDPKSGKQTKAGMKRKLSGDQTAVEPKKPKRSGEMCAFNKVLAHLVAMCDTNMPFIGLRCELFNMEIPHQGVQIEGDGCSHAIRLLKIPPCKGVCEETQKALDRSLLDCTFRLQGRNNRTWVTELIFANCPLNSTNVKEQGLTRHVYLTYENPLSEPVGGRKIVEMFLNDWYSIARLYECVLEFARSLPEIPSHLNVFSEIRMYNYRKLVLCYGSTKGSSVNLEYQRLTNTFMCLESMVSNLSCSSTHFCDLHFLWSSFFFVKNVMISLQVLFDTQAPLNAINKLPTVPMLGLTQRINSAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQPPPQQQQPFGKQPAASGTYPLTSPPTSYHNAVTPSPSMMHTQSPGNLHAANSPSGALRAPSPASFGPTPSPSSLGITMGQTSNFASPHGTLDPSSPYTMMSPSQRAGNWPSSPQVSGPSPAARMPGMSPANPSLHSPIPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALHVLLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEPLQLINSSEPGVIMFKTDALKCRVALNPKTCQTLQLKVTPENAGPWLQEELQVLEKFFETRVAGPPFKANTLLAFTKLLGAPTHILRDCVRIMKLELFPDQAAQLKWSVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKLAVPQEPISIIVPVVYDMASGTTQQADIPRQQSSSGAAAMMVSNILKRFAEMHPPRPGECTIFAAVHDLMANLTLHPTGRS
Length1445
PositionTail
OrganismLatimeria chalumnae (Coelacanth)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Coelacanthiformes> Coelacanthidae> Latimeria.
Aromaticity0.07
Grand average of hydropathy-0.143
Instability index55.00
Isoelectric point8.71
Molecular weight160369.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
blood vessel morphogenesis	GO:0048514	IEA:Ensembl
embryonic viscerocranium morphogenesis	GO:0048703	IEA:Ensembl
neural crest cell differentiation	GO:0014033	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl
ventricular system development	GO:0021591	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29108
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     230.15|      54|      56|    1001|    1055|       1
---------------------------------------------------------------------------
 1001- 1048 (86.20/29.05)	........FGKQPAASG...TYP.LTSP.PTSYHN..AVTP.SP.SM.MHTQSPGNL....HAANSPSGA
 1049- 1105 (78.10/26.69)	LRAPSPasFGPTPSPSSlgiTMG.QTSN.FASPHG..TLDPsSPyTM.M...SPSQ.....RAGNWPSSP
 1107- 1166 (65.85/20.94)	VSGPSP..AARMPGMSP...ANPsLHSPiPDVSHSprAGTS.SQ.TMpTNMPPPRKLpqrsWAASIP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     504.32|     120|     122|     672|     793|       2
---------------------------------------------------------------------------
  542-  668 (162.31/108.29)	VEMFEIPGCPTQLEYKYYFLSVSQSDGddspPIALLLQQFKPNIEELALD..P.KSGK.............QTKAGMKRK..LSGDQTAVEPKKPKRSGEMcaFNKVLAHLVAMCDtnmpfiglrCEL.FN...MEIP.HQGV.QIE...GDGC
  672-  793 (197.41/142.45)	IRLLKIPPCKGVCEETQKALDRSLLDC....TFRLQGRNNRTWVTELIFANCPLNSTN.............VKEQGLTRHVYLTYENPLSEPVGGRKIVEM..FLNDWYSIARLYE.........CVLeFArSLPEIPSHLNV.FSE...IRMY
  797-  916 (144.60/95.53)	KLVL....CYGSTKGSSVNLEYQRLTN....TF.........MCLESMVSNLSCSSTHfcdlhflwssfffVKNVMISLQVLFDTQAPLN.AINKLPTVPM...LGLTQRINSAYQ.........C...FS.ILPQSPTHIRLaFRNmycIDIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     305.99|      83|     149|     285|     372|       4
---------------------------------------------------------------------------
  285-  372 (139.27/98.94)	CLHSFCLSLQLEVLHSQ..AQMLIRE........RWGDLVKVERYLPGKCLTLSVWNQQI...LGRKTGSASVHKVNIKIDEndvskPLQISHEPPLPVCD
  382-  430 (35.69/15.47)	IDHLSVEKLLIDSVHSR..SHQKLQElkailksfNPGDSSFIETALP....TLVV..............................................
  436-  522 (131.02/83.03)	CGRSECLHIFVD.LHSGmfQPMLYGI........DQTTLDDIEKSINDDMKRIIPWLQQLkfwLGQQRCKQSVKHLPTVCTE.....TLHLSNSASHPIGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     233.58|      54|     154|    1169|    1224|       5
---------------------------------------------------------------------------
 1169- 1224 (86.28/64.24)	LTHSAL..HVLLLPSPTPGL....V.PGLAGSYLCSPLERFLGsvIMRRHLQRIIQQEPLQLI
 1234- 1288 (67.76/43.41)	FKTDALkcRVALNPKTCQTLqlkvT.PENAGPWLQEELQ......VLEKFFETRVAGPPFK.A
 1324- 1375 (79.54/52.67)	LKWSVQ..FCLTIPPSAPPI....ApPGTPAVVLKSKMLFFLQ...LTQKL..AVPQEPISII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29108 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQPPPQQQQPFGKQPAASGTYPLTSPPTSYHNAVTPSPSMMHTQSPGNLHAANSPSGALRAPSPASFGPTPSPSSLGITMGQTSNFASPHGTLDPSSPYTMMSPSQRAGNWPSSPQVSGPSPAARMPGMSPANPSLHSPIPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWA
959
1162










Molecular Recognition Features






MoRF SequenceStartStop




NANANA