<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29107

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFSGDEYGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQINAKDNYWLVTARSQSAIHNWFTDLAGSKPLTILTKKVPILSKKEDIFAYLAKYLVPVLRAAWLIKMTCAYYAAISEAKVKKRQAMDPNVEWTQILTRYLREQLSKIAEFYHMTSNQGSNVATIPPEVEQAMKQWEYNEKLAFYMFQDGMLERHEYLTWILDVAEKVRAADEELLKLLLPLMLQYSEEFVQSAYLSRRLAYFCTRRLSLMLSESPNLISAHSPHVIIGSNNLPLAAPSPTTTGAVVSPMQSAFSDFLSCAQHRPLIYGLSCMLQTITLCCPSALVWNYYTSESKSSNPGSPLDFLQVAPSSLPIPGGNSVFNQQVRAKIHEIEQQIKQRGRAIEVRWSFDKCQESVAGFPIYKVLHILEVLDRHCFDRSDSSNSLDTLYHKIFWPNQSKDSQEILPNGEAVVTLLCEWAVSCKRFGKHRAVAVAKLLEKRQVEVEAERCGESEVLDEKESISSVSLAGSSLPVFQNILLKYLDTQGPVLTDPNNETEKTEFINLVLLFCEFIRHDVFSHDAYMCTLISRGDLSSMISAAGPRSPAGENPSEHYRKDHELKQEIFSPMPGEPLTYENVNCLDRRIAVIEEMAWRTEKQKELVFSSTYDLPRHLQYATHFPIPLDDSSSHECNQRVILLYGVGKHRDEARHQLKKITKDILKILNKKSTTETALTDDGQKTKKSKQETFPTLETVFTKLQLLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMESALNINGLLDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCLCIVAVLRSYHTCLIQYSDQTAQAFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMMDFIENPSVHNINYSMLGKILSDSATNRYSFVCNVLMNICMGHQDANRINDIANFCAELTACCTILSSEWLGVLKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLAIFIAILIAHQCFSLEDVVQHVALPSLLTAACGDPDAEPGARMTCRLLLHLFQSPQVNSFPQASGKEVPGILSSCDRHLLAAAHNSIEVGAVFAILKAILMLGDAEIGSSNVNSSSNEGFSVASLLAPVGGLDQINDDHKTSKSGGRAFSRETASLSEYARYALRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECMEGENLQRQNIKRILQNLDQWTLRQSWLELQLMIKQCTKEPGSASVAEMNILLDDIAKATIEVFQQSAELNSNPTSSGIGIFSTNNVSSADSNNARQNGKKAFLSSSERKGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQRPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILINWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTSDWALLLLQIITSGTVDIQTNNELFTAVLDMLGVLINGTLAFDLSNASQGGSEENKRAYMNLVKKLKKELGDKHSESIDKVRQLLPLPKQTYDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGHKNPTPLSWAWFGTVRIDRKVIKYEEQQHLLLYHTHPKPKPRSYYLDPLPLPSEEEEDEPPTPVSQEPEKKQAELLEQNASTLEEEKKTKGRKRKTKSNSRPDDYPENNNLYRAPPNYPPMISQTIPHPQPVSSWGYSLYGQPQQQHFYLQNQPLPPGGHRLEPMSQFAPTNMTDTKQALSNMLQRRSGSVIQPHSIHAVSPQQQLLQMKLLQQQQQQRLLRQQLQAKPFQQGQPVDQAGVFVQQVQPLTPLSQYPGMQHAQTLPLGYTTYSSLIPLQQQSGSAVLSPNYVTRTYQPAHTNPLLLERLRQLQQQPSGYIQQQTSAYLQPFAGSQSLTHQPLQQNSLIGGLDSVGSTAPLPNLGSVQMSQEQIRQRQQQLRQQRLLQVRENICIYPDKKLPLKGTLLQQQQQNQQGLGIQAMQSQQSLFSRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQASNPYGHPQHY
Length2154
PositionKinase
OrganismLatimeria chalumnae (Coelacanth)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Coelacanthiformes> Coelacanthidae> Latimeria.
Aromaticity0.07
Grand average of hydropathy-0.382
Instability index56.96
Isoelectric point6.94
Molecular weight242097.05
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29107
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     382.08|      52|      92|    1826|    1877|       1
---------------------------------------------------------------------------
 1630- 1677 (30.72/12.22)	......................................................PLPKQTYDV.itcEPMGSLI...DTkgnkiagfDSIDKKQG....L.....QVSTKQ.KVSP
 1687- 1768 (42.54/20.56)	PtplswawfgtvridrkvikyeE..QQHlllyhthpkpkprsYYL......DPLPLPSEEEED....EP........PT........PVSQEPEKKQAEL.....LEQNAS.TLEE
 1826- 1877 (96.14/58.40)	P.....................Q..QQH..............FYL......QNQPLPPGGHRL....EPMSQFA...PT........NMTDTKQALSNML.....QRRSGS.VIQP
 1885- 1923 (30.42/12.01)	P.....................Q..QQL..............LQMkllqqqQQQRLLRQQLQA....KPFQQGQ...P...........VDQAG......................
 1925- 1971 (51.27/26.73)	..........................................FVQ......QVQPLTPLSQ.Y....PGM.QHAqtlPL........GYT.TYSSLIP.L.....QQQSGSaVLSP
 1972- 2012 (56.13/30.15)	N.....................Y..VTR..............TYQ......PAHTNPLLLERL....RQLQQ.Q...P..................SGYI.....QQQTSA.YLQP
 2023- 2050 (39.89/18.69)	P.....................L..QQN..............SLI.............GG..L....DSVGSTA...P.................LPNL..........GS.V.QM
 2053- 2102 (34.97/15.22)	E.....................QirQRQ..............QQL......RQQ.......RLlqvrENICIYP................DKKLPLKGTLlqqqqQNQQGL.GIQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.47|      28|     150|      79|     112|       2
---------------------------------------------------------------------------
   79-  112 (39.34/39.97)	EKLKLNTFQDtGkkkpqINAKDNY..WL..VTARSQSA
  234-  265 (42.13/25.38)	EKLAFYMFQD.G.....MLERHEYltWIldVAEKVRAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.58|      18|     150|     895|     924|       3
---------------------------------------------------------------------------
  905-  923 (31.73/39.43)	QAFeGLCGVVKHVVNPS....EC
 1097- 1118 (29.85/ 6.14)	QCF.SLEDVVQHVALPSlltaAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.97|      22|     151|    1357|    1387|       4
---------------------------------------------------------------------------
 1135- 1159 (37.33/15.14)	LHLF.QSPQVNSFPQASGkevPGILS
 1364- 1386 (35.64/20.27)	IEVFqQSAELNSNPTSSG...IGIFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.39|      43|     160|     473|     528|       9
---------------------------------------------------------------------------
  473-  528 (57.45/67.80)	RSDSSNSLDTLYHKifwPNQSKdsQEIL.P.NGEAvvtlLCEWAVSCkrfgKHRAVAV
  637-  681 (71.93/44.29)	RSPAGENPSEHYRK...DHELK..QEIFsPmPGEP....LTYENVNC....LDRRIAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.61|      54|     189|     842|     896|      11
---------------------------------------------------------------------------
  842-  896 (86.02/63.62)	ALNINGLLDFAIQLLNELSVVEAELL..LKSSSLAGSYTTGL..CLCIVAV..LrSYHTCL
 1027- 1086 (85.58/58.38)	ANRINDIANFCAELTACCTILSSEWLgvLKALCCSSNHVWGFndLLCSVDVsdL.SFHDSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.19|      14|     193|    1394|    1407|      12
---------------------------------------------------------------------------
 1394- 1407 (25.61/16.51)	DSNNARQNG....KKAFL
 1587- 1604 (20.57/11.66)	DLSNASQGGseenKRAYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.55|      39|     189|    1293|    1335|      22
---------------------------------------------------------------------------
 1296- 1335 (67.77/57.41)	YPHGIK.ECMEGENLQ.RQNIK........RILQN.....LDQWTLRQSwLELQL
 1478- 1507 (24.40/ 9.68)	........CLKGQDEQ.REGLL........TSLQNqvnqiLINW..REE......
 1509- 1554 (48.37/26.03)	YQDDIKaRQMMHEALQlRLNLVggmfdtvqRSTQW.....TSDWAL....LLLQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29107 with Med12 domain of Kingdom Metazoa
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