<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29100
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | GMLQLGYSEPVVPPEMMPVNQNHMPQMQGGGTIPLSLLVEFVVHKTYHDITVMADLLPGKSDLERKIAVVQFATKYRQLFIRLFSLVKWASSVDKVVKCGDISSFLDHQAMLFVDTADKLYMMSNQLLIQARLPNFSIPTAVDVLTNGTYTRLPTCIRDRVIPPKAILPSEKRATLKRIEQIVLFRLVSEIIPPQIKDLTVERGIVHLTVPGKFRASLTLMGDSDLLPWRLIKLTLLKTTNQPVNIAKPQSPKPLIVQSVVNLRQTVNIGGGIGVQDGAFSQFDYSKVKSGCVPIPGLCSFLARFQDPKDSRYKSDLEKDNPPSPNSALNSSQNKFGLMEVASGSWSGSQPSVLSHAALHGLCSKLANIHPMQASKCSQIEQFFGSLIVKRHLEKCVRLVDIGAGSQSIRVVQENWTPEDLQTLEKYFDSRITCSPYRYNAVASFVNMIFAPAYILRDFMQVMQLELTGRVIAPGMQTNTKWNMNICLTSPPRIPITLLGMPSILVRDKVLLFVQLTQAVPQNNAPNTIVVPLLHDRQSKSVQILPHAMNAQTQATRNLQHTATLLTRLDELRIQQPINDQNFLSVAVHYLMENLTFP |
Length | 598 |
Position | Tail |
Organism | Ciona savignyi (Pacific transparent sea squirt) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Tunicata> Ascidiacea> Phlebobranchia>
Cionidae> Ciona.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.022 |
Instability index | 41.84 |
Isoelectric point | 9.34 |
Molecular weight | 66734.11 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP29100
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 246.87| 84| 295| 78| 196| 1
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21- 104 (90.20/51.21) QNHMPQMqgggTIPLSllVEFVVHKTYHDI.TVMAD..LLPG...KSDL..ERKiavvqfAT.....................kyrQLFIRlfSLVKWASSVD...KV.VKCGDISS
130- 196 (75.97/95.06) QARLPNF....SIPTA..VDVLTNGTYTRLPTCIRDR.VIPP...KAILpsEKR......ATLKRIEQIVlfrlvsEIIPPQI..................................
206- 282 (80.71/41.40) ..................VHLTVPGKFRASLTLMGDSdLLPWrliKLTL.............LKTTNQPV......NIAKPQS.pkPLIVQ..SVVNLRQTVNiggGIgVQDGAFSQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 77.83| 22| 63| 297| 319| 2
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297- 319 (36.42/24.34) GLCSFLARFQDPKDSRYkSDLEK
361- 382 (41.41/23.63) GLCSKLANIHPMQASKC.SQIEQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 132.22| 39| 52| 421| 464| 3
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421- 464 (65.91/44.47) LQTLEKYFDSRITCSPYRYNavasfVNMIFAPAYILRD....FMQVMQ
476- 518 (66.31/35.60) MQTNTKWNMNICLTSPPRIP.....ITLLGMPSILVRDkvllFVQLTQ
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