<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29061
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MQAEIGLEVYETPCKLPITPLIANNHPTDETSKPRFAEINQHNSVPLPACYSLKLHPPVPILDHIVKQIEQETKLPVLYKDKSTSYLSLIQKDDECCKVTFGSVTHRHHLDFSHVEGLLVHQVRFTSPEHVVAVINLLRKQCYLNTVLTSCMRKSKKAQG |
Length | 160 |
Position | Middle |
Organism | Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Tunicata> Ascidiacea> Phlebobranchia>
Cionidae> Ciona.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.284 |
Instability index | 41.79 |
Isoelectric point | 8.21 |
Molecular weight | 18146.84 |
Publications | PubMed=12481130
PubMed=15114417
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP29061
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 142.80| 42| 63| 29| 70| 1
---------------------------------------------------------------------------
29- 70 (73.30/40.31) DETSKPRFAEINQHNSVPLPACYSLKLHP.PVPILDHIVKQIE
94- 136 (69.50/37.91) DECCKVTFGSVTHRHHLDFSHVEGLLVHQvRFTSPEHVVAVIN
---------------------------------------------------------------------------
|