<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29043

Description Mediator complex subunit 14
SequenceMAPVQIGTDGQLVPLGGPVLSGPQPPPTGGGATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLDILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYTCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLSVWNQQVLGRKTGTASVYKVTIKIDESDGSKPLQISHEPPLPSCDSKLIERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKANNPSDNAFIETALPTLIIPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKSINDNMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCTNVLHLSNSASHPVDSLSKHKLFVKLTRLPQYYIAVEMFEMPNSPTALQYKYSFLSVSQLEGEDGPLCAQLLQPFKPNLEQLAQDTIKGKGARPGTKRKAASAKISGEHGDPEPKKPKRSGEMCAFNKELAHVVAMCDTNMPFIGLRVELANMEIPNQGVQVEGDGSSHAICLLKIPPCKSVGEETRRALERSLLDCTFRLQGRNNRTWVAELVLANCPLNSTHSKEQASTRHIYLTYENPLSEPVGGRKVVEMFLNDWTAISQLYQCVLNFSRTLPDMPSYLSLFSEVRLYNYRKLVLCYGATKGSSVTIQWNSSSQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVMQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSATHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLTMFVDSNQDARRRSVNEDDNPPSPVGVDVADTLMNQLQAQQQPQPMRATAGGVYPPLTSPPPNYHANVAPSPSMMPTQSPGTGMDPSSPYAMVSPSHRGQWPGSPQFSGPSPGARIHSMSPGNPSLHSPIPDPHSPRAGTSSQIMPTSMPPPRKLPQRPWAASIPTILTHNALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEANLSIVNSNEPGVIMFKTDMLKCRVALNPKNYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAGQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRLPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQGECTIFASVHELMANLTLPPCTRQ
Length1400
PositionTail
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.06
Grand average of hydropathy-0.187
Instability index49.50
Isoelectric point8.74
Molecular weight155697.46
Publications
PubMed=21551351

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29043
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     316.09|     102|     454|     593|     894|       1
---------------------------------------------------------------------------
  593-  705 (158.46/322.55)	KGARPGTKR...KAASAKI.SGEHGDPEPKKPKRSgemcAFNKELAHVVAMCDTNMP...FIGLRVELANmeIPNqgvqVEGDGSSHaICLLKIP.PC...KSVGEETRRALERSLLDCTFR..LQ
 1053- 1167 (157.63/38.48)	RGQWPGSPQfsgPSPGARIhSMSPGNPSLHSPIPD....PHSPRAGTSSQIMPTSMPpprKLPQRPWAAS..IPT....ILTHNALH.VLLLPSPtPClvpGLAGSYLCSPLERFLGSVIMRrhLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     248.27|      70|     454|     822|     894|       2
---------------------------------------------------------------------------
  822-  894 (114.37/61.02)	RFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPnVMQLLQVLYDTQAPLNAInkLPTV.PM.LGLTQRTNTAYQ
 1010- 1035 (25.65/ 6.08)	......PPLTSP..PPNYHANVAPSPSMMPTQSP.........................................
 1284- 1350 (108.25/50.11)	QFCLTIPPSAPPIAPPGTIAVVLKS.KMLF.....FLQLTQRLPVPQDPVSII..VPIVyDMaTGLTQQADIPRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29043 with Med14 domain of Kingdom Metazoa
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