<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29042

Description Mediator complex subunit 14
SequenceMAPVQIGTDGQLVPLGGPVLSGPQPPPTGGGATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLDILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYTCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLSVWNQQVLGRKTGTASVYKVTIKIDESDGSKPLQISHEPPLPSCDSKLIERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKANNPSDNAFIETALPTLIIPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKSINDNMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCTNVLHLSNSASHPVDSLSKHKLFVKLTRLPQYYIAVEMFEMPNSPTALQYKYSFLSVSQLEGEDGPLCAQLLQPFKPNLEQLAQDTIKGKGARPGTKRKISGEHGDPEPKKPKRSGEMCAFNKELAHVVAMCDTNMPFIGLRVELANMEIPNQGVQVEGDGSSHAICLLKIPPCKSVGEETRRALERSLLDCTFRLQGRNNRTWVAELVLANCPLNSTHSKEQASTRHIYLTYENPLSEPVGGRKVVEMFLNDWTAISQLYQCVLNFSRTLPDMPSYLSLFSEVRLYNYRKLVLCYGATKGSSVTIQWNSSSQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVMQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSATHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLTMFVDSNQDARRRSVNEDDNPPSPVGVDVADTLMNQLQAQQQPQPMRATAGGVYPPLTSPPPNYHANVAPSPSMMPTQSPGNIHTSGSPSGVLRAPSPFGPTPSPSSLGIAMGQTSFASPHGSQIMPTSMPPPRKLPQRPWAASIPTILTHNALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQELSIVNSNEPGVIMFKTDMLKCRVALNPKNYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAGQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRLPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQGECTIFASVHELMANLTLPPCTRQ
Length1374
PositionTail
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.06
Grand average of hydropathy-0.159
Instability index49.58
Isoelectric point8.71
Molecular weight152900.45
Publications
PubMed=21551351

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP29042
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.62|      36|     241|    1022|    1068|       1
---------------------------------------------------------------------------
 1022- 1063 (54.00/41.97)	PSMMPtQSP..GNIHT..SGSPSGVLRAPSPfGPTPSPsslGIAmG
 1083- 1122 (58.62/21.75)	PRKLP.QRPwaASIPTilTHNALHVLLLPSP.TPCLVP...GLA.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.31|      32|     241|      58|      92|       2
---------------------------------------------------------------------------
   58-   92 (49.39/46.68)	ELLPRKTDM...ERKIEIVQfasRTRQLFVRLLALVKW
  293-  327 (52.93/40.10)	EVLHSQTLMlirERWGDLVQ...EERYVPAKYLTLSVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     311.20|     101|     326|     832|    1000|       4
---------------------------------------------------------------------------
   95-  206 (150.14/74.98)	NA.GKVEKCAMISsfLDQQTilfvDTADRLASLARDALVHARLpSFAIPFAIDVLTTGsypRLPTCIRD.........KIIP...PDPITKSEkQTTLNQLNQILRHRLVT.TDLPPQLANLTVAN
  867-  981 (161.05/144.13)	NAiNKLPTVPMLG..LTQRT....NTAYQCFSILPQSATHIRL.AFRNMYCIDIYCRS...RGVVAIRDgayslfdntKIVEgfyPAPGLKTF.LTMFVDSNQDARRRSVNeDDNPPSPVGVDVAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29042 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQDTIKGKGARPGTKRKISGEHGDPEPKKPKRSGE
2) NQDARRRSVNEDDNPPSPVGVDVADTLMNQLQAQQQPQPMRATAGGVYPPLTSPPPNYHANVAPSPSMMPTQSPGNIHTSGSPSGVLRAPSPFGPTPSPSSLGIAMGQTSFASPHGSQIMPTSMPPPRKLPQRPWA
586
957
620
1092










Molecular Recognition Features






MoRF SequenceStartStop




NANANA