<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29038

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTEMFSTLFGQNEAQGPPGSSSLGFGPSKPPPPLPQSQVPLAAQMPPQLGDEGPALRKPGAMNEPFYLLRELPGNELTGNTNLITHYNLEHAYNKFCGKKVKEKLSNFLPELPMIDCPGTQDGSSLRSLIDKPPVCGNSFSPLTGALLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHKHHRPQDPLPQTPSDTDPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDHPGLTGSQPNSSSLR
Length241
PositionHead
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.05
Grand average of hydropathy-1.089
Instability index54.68
Isoelectric point9.81
Molecular weight26746.35
Publications
PubMed=21551351

Function

Annotated function 
GO - Cellular Component
nuclear MIS12/MIND complex	GO:0000818	IEA:InterPro

GO - Biological Function
GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
cell division	GO:0051301	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29038
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.57|      27|     113|      99|     127|       1
---------------------------------------------------------------------------
   99-  127 (44.47/26.61)	KKVKEKLSN.FLPELPMIdcPGTQ.DGSSLR
  213-  241 (41.10/18.58)	KKDKKKKKNrHSPDHPGL..TGSQpNSSSLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.31|      17|      18|     170|     186|       2
---------------------------------------------------------------------------
  170-  186 (33.39/14.39)	PKKKSKHKHKHHRPQDP
  191-  207 (30.92/12.86)	PSDTDPKKKKKKRDDDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29038 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FLPELPMIDCPGTQDGSSLRSLIDKPPVCG
2) LLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHKHHRPQDPLPQTPSDTDPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDHPGLTGSQPNSSSLR
3) MFSTLFGQNEAQGPPGSSSLGFGPSKPPPPLPQSQVPLAAQMPPQLGDEGPALR
108
147
4
137
241
57










Molecular Recognition Features






MoRF SequenceStartStop




1) DPKKKKKKRDDDPDRKKKKKDKKKKKNRHS
2) FYLLREL
3) YRLMHIQ
195
66
162
224
72
168