<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29037

Description Mediator complex subunit 12
SequenceMMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSARNVNFNPSKISSNFSSIIAEKLRYNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQFPNQGCSSPLPAMPADVDTAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRFLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSMGPSAAGHPGHGILAQQGNALPPTPTSQPSGGNQPQTPFTDFYICPQHRPIVYGLSCMLQSIVLCCPSALVWHYSLTDCRNKTGSPLDLLPIAPSSLPMPGGNTALTQQVRTKLREIEEQVKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFEKSDFNNSLDLLYNRIFGSGQSKDSHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSVSSGSLSAATVPVFQDVLLQFLDTQAPTLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKDQEAGSNCKNEDTSLSESMEIDHNSSANFDEMFSPPMHCESKGSPSPEKPAPEQDSKGSSKDKGMDPAFPQLYDQPRHIQYATHFPIPQEESSSHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGGEEGQKRKKSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSNLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYNSCSHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPGFMMEAIANPSAHNFNHSMVGKILNDSPVNRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVKSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHTSGLDDISEGGNVSIETASLDAYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSSNPSGNGAVGSGGSTSNSNSTASKMKPILSSSERSGVWLVAPLIAKLSTAVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQLQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTIRVDRKVNKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPVSQEPEKKMMEAVKPEKTVPGVPSDSNKKKSNKKKKNSSNKTEDGVNRAAGGVSYGPNMPPELMQNPYGRIPYGQQAMNMYTQNQPLPPGGPGLEPPYRPARNQQMNKMMPVRPNYTGMMSGMQGNMPSMMGLDKQYSMGFKPQPSMPQGQILRHQLQVRLNQSMIGQQMRQMTPNQPYTSMQASQNLSQGYTTFGSHMGMQQHPSQTGGMAPSSYGNQNFQGTHPANNPAVVDPHRQLQQRPSGYVHQQAPGYPHNMQNTQRFPHXPIQQNPIMHSMGHMGGQGVHPGMRPNQMLAEQQQQQQQQQQQQAAQQQQQYLRQQQALRQQQQQQAQQVQQQQVQPQQVPPQQQVQQQQQQQQQQVSSVPPPGQAQNQALGMQPLPPQQPMFPRQGMQQTQQQQQTAALVRQLQQQLSNSQPGQGTNSYF
Length2156
PositionKinase
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.07
Grand average of hydropathy-0.533
Instability index55.48
Isoelectric point6.80
Molecular weight241415.32
Publications
PubMed=21551351

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     345.46|      53|      53|    2028|    2080|       1
---------------------------------------------------------------------------
 1864- 1912 (73.96/25.53)	KQY...............SMGFKPQPSMPQGQILRHQLQVRLNQSMIGQQ.....M..............RQMTPNQ..PYTS...MQ
 1913- 1967 (47.39/13.87)	ASQnlsqgyttfgshmgmQQHPSQTGGMAPSSY..........GNQNFQG.....THP............AN.NPAVVDPHRQ.....
 1970- 2029 (40.19/10.71)	...........................QRPSGYVHQQAPGYPHNMQNTQRfphxpIQQnpimhsmghmggQGVHPGMRPNQML.aeQQ
 2030- 2083 (93.12/33.93)	QQQ...............QQQQQQQAAQQQQQYLRQQQALRQQQQQQAQQ.....VQQ............QQVQPQQVPPQQQ..vQQ
 2084- 2121 (56.40/17.82)	QQQ...............QQQQQV..S...........SVPPPGQA..........QN............QALGMQPLPPQQPmfpRQ
 2122- 2150 (34.41/ 8.17)	GMQ...............QTQQQQQTA...........ALVRQLQQQLSN.....SQP............GQ................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.09|      15|      15|     836|     850|       5
---------------------------------------------------------------------------
  836-  850 (26.84/16.86)	LEQITSFALG.MSYHL
  852-  867 (23.25/13.61)	LVQHIQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.69|      30|      90|    1723|    1752|       6
---------------------------------------------------------------------------
 1723- 1752 (53.52/28.54)	EEEPLTPVSQEPEKKMMEAVKPEKTVPGVP
 1801- 1821 (35.10/16.03)	......PYGQQ.AMNMYTQNQP..LPPGGP
 1823- 1846 (40.06/19.40)	LEPPYRPARNQQMNKMM.PVRPNYT.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     205.73|      36|      81|     710|     745|       7
---------------------------------------------------------------------------
  627-  652 (39.75/18.24)	RG...DLASDSHLP......RPRS...PSDEPSDES.ER
  656-  694 (46.95/22.93)	EAGSNCKNEDTSLSESMeiDHNSSANFDEMFSPPMHcES
  710-  745 (63.37/33.63)	KGSSKDKGMDPAFPQLY..DQPRHIQYATHFPIPQE.ES
  794-  829 (55.66/28.61)	EGQKRKKSKPEAFPTAE..DIFSKFQHLSHFDQHQV.TS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     142.06|      28|      48|     963|     990|      10
---------------------------------------------------------------------------
  963-  990 (49.29/33.32)	NSCSHLKN..K..FGEIFSEFCSKV.K......NSIYCN
 1011- 1039 (34.76/21.04)	NPSAHNFN..HsmVGKILND..SPVnR......YSFVCN
 1043- 1069 (34.06/20.45)	DVCVDHRDpeR..VNDI.GILCAEL.........TAYCR
 1071- 1099 (23.95/11.90)	.....LSA..E..WLGILKALCCSS.NngncgfNDLLCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.78|      41|     320|     244|     302|      19
---------------------------------------------------------------------------
  248-  292 (68.90/84.64)	MLDRHEFLTWVLECFEkvrpGEDE....LLRFLLPLLLQYSGEFVQSAY
 1454- 1498 (66.89/36.08)	LLSQQPFLSLVLTCLK....GQDEqregLLTSLYSQLQQIVTNWREDQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.21|      24|     107|    1565|    1590|      20
---------------------------------------------------------------------------
 1541- 1564 (39.25/23.96)	LDIISSGTV..DMQSNNELFTTVLDM
 1565- 1590 (33.95/25.97)	LSVLINGTLaaDMSSISQGSMEENKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29037 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASDSHLPRPRSPSDEPSDESERKDQEAGSNCKNEDTSLSESMEIDHNSSANFDEMFSPPMHCESKGSPSPEKPAPEQDSKGSSKDKGMDPAFPQLYDQPRHIQYATHFPIPQEESS
2) FQKSAEMNSSNPSGNGAVGSGGSTSNSNSTASKMKP
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSARNVNF
4) SYYLEPLPLPPEEEEPLTPVSQEPEKKMMEAVKPEKTVPGVPSDSNKKKSNKKKKNSSNKTEDGVNRAAGGVSYGPNMPPELMQNPYGRIPYGQQAMNMYTQNQPLPPGGPGLEPPYRPARNQQMNKMMPVRPNYTGMMSGMQGNMPSMMGLDKQYSMGFKPQPSMPQGQILRHQLQVRLNQSMIGQQMRQMTPNQPYTSMQASQNLSQGYTTFGSHMGMQQHPSQTGGMAPSSYGNQNFQGTHPANNPAVVDPHRQLQQRPSGYVHQQAPGYPHNMQNTQRFPHXPIQQNPIMHSMGHMGGQGVHPGMRPNQMLAEQQQQQQQQQQQQAAQQQQQYLRQQQALRQQQQQQAQQVQQQQVQPQQVPPQQQVQQQQQQQQQQVSSVPPPGQAQNQALGMQPLPPQQPMFPRQGMQQTQQQQ
631
1359
16
1711
746
1394
65
2130










Molecular Recognition Features






MoRF SequenceStartStop




1) KPIPVEVKKEPEAPTEVVKQEEREPGTKSAAPAAPSKQPPEKRARLQ
2) LLLDLR
200
180
246
185