<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29031

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSYVPNGASLEDCHSNLFCLADLTGIKWKRFVWQGPTSAPMLFPVTEEDPILCSFSRCLKADVLCVWRRSQRQGRRELWMFWWGDDPNFADLIHHELAAEDDGLWENGLSYECRTLLFKAIHNLLERCLMNRSFVRIGKWFVKPYEKDEKPINKSEHLSCAFTFFLHGDSNVCTSVEVNQHQPVYHLTEEHLTLAQQSSSPFQVILSPFGLNGTLTGQSFKMSDPPTQKLIEEWNQFYPISSKAKEGVSEDKLEDMDWEDDSLASVEVLVGGVRMVYPACLVLVPQSDIPVVAPVGSSQCTTVYSSGHQVPASQREPAMSLVTLTPPTSPEEVQTLDSHSAQKWVKMPSTSDLFSVDRPSHHGGKIPQRLASQMVERVWQECNTNRAQNKRKFSAAATGTCEEDLKEKIGSWNFVEHSRRPYCSCCRYKSLKQRVSSTPGQAQTTGQLSQPPSKHKTGEGKADKVDKQQKRPHTPFHHRSLTSDDSSIETETTAGQNLTMRAQDGARFTGIRSSDMSSIQKAPQLHTGVVNTGPSEQTNSPQPPPLSPHPSERNDESGEVTKNLSSPNSQHFYQPPPEPCLVGVKTVGSSEEHGGSDSLNQHFQSHHLNPGISSFSEPPEPTIYVGTGLNLEDDSLHMPWRLFKLPHRKEANLPTPLLPGDKLREEASGFHDSLLTATEVMSTSKRHLKVSDERIQMYLARRNQYLCAVLTDGGHEPEVDPYAFEEGDVKFTFSNKKDKTGGEREPGKKHKAEDGGLGPSDDAQRGAAHNRMASTSLIHETDLVVSINDLDNLFNSDEDDLAPGLKRPVNGTDDKFSGKEPKPSSLDSVPCDLHQMFPTPPSLEQHIMGYSPMNMCSKEYGSMEANSGMTSLDGTSSLGGHFKIEVEESFCSPKPSEIKDYSFVYKPELCQAFVGCSMFAPLKTLPSQCLAPIKIPDDCIYKPSWTMGRELLNPMSVMTFLNKDSNIPSVGSTMDQDYNQTYTPQTHTPFMSNSAPPSNSGTGILPSPATPRFSAPTPRTPRTPRTPRGPASVQGSLKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVTLILSESVMNLFKDCNFDSCCICVCNMNIKGADMGVYLSDPVGEAQEPCSCGFSSVVNRRYGNGCGLFLEDELDIIGRGSDISREAEKRFEELRLSSLERAGVGRSEHVPDEIILLLQDQCTNPFSPILTLEQDIVARGANGAPVSPCVRVEERDYCSDCYMALEHGRQFMDNMSGGKVDEALVKSSCLHKWTKQNAVDVSALCSQDVLHVLLSLQPLLQDAIQKKKTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDIGYMVVCPDNEALLSNAKSFFRDLTAVYESCRLGQHRPISKGYPDGIVLVGGSDAKTLVDQPVSDWFLKAASSNGDAFTRLKLYAQVCRHNLAPYLASQPLDSSLLSQPFPSPTQSSSTQTSSSTSSQQGPGNTGGSSISSSSISGSVNGSTSSSSLMTSAGQPSSGMPSSKPTSFPPFGSMSTQAQGGAPQSGQLGQQASAHNTGSSGESSSSHALGPTEPPESTLEREKIGIPTDGESHAITYPPAIVVYIVDPFSYDEANGATGPVPTHSSVWTLGLLRCYLEMLQFLPPHIRNIISVQIVPCQYLLQPVRGEDRHIYAQHLKSFAFSVYAQCRRPLPTTTNVKSLTGFGPGLAIDTALRVPERPECLRLYTPPFILAPVKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLATCTDLYGELLETCIINIDVPNRARRKKGSVRRLGLQKLWDWCLGLVQMTSVPWRIVIGRLGRIGHGELKDWSILLSRRNLQSLSRRLKEMCRMCGISSSDTPSILSVCLVAMEPQGSFFIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSAFVQVASSSYTNIDTNIDILNATTDGSDAIGIFDLLDQENDLVDPDIINISPTTSPVHSPGSHYHHGGDGSKGQSTDRMESHEEVPNLLQQPLSLGYLVSTVKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVSSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQLYNFIMNML
Length2159
PositionMiddle
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.07
Grand average of hydropathy-0.412
Instability index55.82
Isoelectric point5.68
Molecular weight237658.97
Publications
PubMed=21551351

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29031
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.87|      32|      32|    1015|    1046|       1
---------------------------------------------------------------------------
  984- 1015 (39.32/16.08)	..TPQT.HTPfMSNSAPPSNSGTgiLPSPATPRFS
 1016- 1047 (60.05/28.76)	APTPRTPRTP.RTPRGPASVQGS..LKYENSDLYS
 1049- 1076 (46.50/20.47)	ASTPSTCR.P.LNSVEPATVP.S..IP.EAHSLY.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.21|      29|      33|     543|     573|       2
---------------------------------------------------------------------------
  543-  565 (35.40/16.98)	.......................QPPP...L....SPHPSERNDESGEVTKNL
  567-  598 (17.58/ 9.83)	SPNsQHF...............yQPPPepcLvgvkTVGSSEEHGGSD......
  599-  643 (39.24/17.16)	SLN.QHFqshhlnpgissfseppEPTI...Y....VGTGLNLEDDSLHMPWRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.92|      37|      37|    1476|    1512|       3
---------------------------------------------------------------------------
 1476- 1512 (66.24/24.97)	LDSSLLSQP..FPSPTQSSSTQT......SSSTSSQQGPGNTGGS
 1514- 1542 (35.11/10.06)	ISSSSISGS..VNGSTSSSSLMT......SAGQPSSG........
 1544- 1583 (42.56/13.63)	....PSSKPtsFP.PFGSMSTQAqggapqSGQLGQQASAHNTGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     461.90|     120|     513|    1197|    1317|       4
---------------------------------------------------------------------------
 1197- 1317 (206.16/132.19)	QCTNPFSPILTLE..QDIVAR........GANGAPVSPCVRVEERDYCSDCY.....MALE.HGRQFM..DNMSGGKVDE...ALVKSSCL.H..KWTKQNAVDVSALCSqDVLHVLLSLQPLLQDAIQKKKTVRSWGVQGPLTW
 1710- 1835 (170.36/104.35)	QCRRPL.PTTTNV..KSLTGF........GP.GLAIDTALRVPERPECLRLYtppfiLAPV.KDKQTE..LGETFGEASQkynVLFVGYCLsHdqRWLLATCTDLYG....ELLETCIINIDVPNRARRKKGSVRRLGLQKLWDW
 1860- 1950 (85.39/48.06)	GELKDWSILLSRRnlQSLSRRlkemcrmcGISSSD.TPSI.......LSVCL.....VAMEpQGSFFImpDSVSTGSV......FGRSTTL.N..MQTSQLNTPQDTSCT....HIL............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.15|      29|      37|      20|      56|       5
---------------------------------------------------------------------------
   20-   51 (48.50/42.44)	CL.ADLTGIkWKRFVWQGPTSAPMLFpvTEEDP
   59-   88 (57.64/27.41)	CLkADVLCV.WRRSQRQGRRELWMFW..WGDDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     247.55|      77|     513|     227|     366|       6
---------------------------------------------------------------------------
  278-  358 (128.56/126.59)	YPA......CLVLVPQSDIPVVAPVG..SSQCTTVYSSGHQVPASQREPAMSLVTLTPPTSPEEvqtlDSHSAQKWVKMPSTSDLFSVD
  699-  783 (119.00/40.30)	YLArrnqylCAVLTDGGHEPEVDPYAfeEGDVKFTFSNKKDKTGGEREPGKKHKAEDGGLGPSD....DAQRGAAHNRMASTSLIHETD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.73|      28|      33|    1092|    1124|       7
---------------------------------------------------------------------------
 1092- 1124 (43.64/39.96)	CNFDSccicVCNMNIkGADMGVYLSDP...VGEAQE
 1128- 1158 (48.09/26.90)	CGFSS....VVNRRY.GNGCGLFLEDEldiIGRGSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.03|      33|      33|     458|     490|       8
---------------------------------------------------------------------------
  433-  465 (38.79/17.93)	...KQRVSSTPGQAQTtgqLSQPPSKHK......TGEGKADK
  466-  497 (56.70/29.77)	VDKQQKRPHTPFHHRS...LTSDDSSIE......T.ETTAGQ
  501-  529 (26.54/ 9.83)	MRAQDGARFTGI..RS.....SDMSSIQkapqlhTG......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.96|      19|      33|     905|     923|       9
---------------------------------------------------------------------------
  842-  854 (21.90/10.46)	...PSLEQHIMG...YSPM
  905-  923 (36.33/22.81)	VYKPELCQAFVGCSMFAPL
  941-  956 (32.73/19.73)	IYKPSWT...MGRELLNPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.23|       8|      25|    1589|    1598|      11
---------------------------------------------------------------------------
 1589- 1598 (12.31/11.50)	SHALgpTEPP
 1615- 1622 (17.92/ 7.82)	SHAI..TYPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.82|      12|     514|     808|     827|      13
---------------------------------------------------------------------------
  808-  824 (13.34/17.43)	RPVNgTDDKFsgkePKP
  830-  841 (25.48/ 6.18)	VPCD.LHQMF....PTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.06|      13|      37|    1383|    1395|      15
---------------------------------------------------------------------------
 1383- 1395 (22.74/13.60)	PDNEALL....SNAKSF
 1419- 1433 (15.45/ 6.58)	PDGIVLV..ggSDAKTL
 1437- 1453 (17.87/ 8.91)	PVSDWFLkaasSNGDAF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29031 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIINISPTTSPVHSPGSHYHHGGDGSKGQSTDRMESHEEV
2) FSNKKDKTGGEREPGKKHKAEDGGLGPSDDAQRGAAHNRMAST
3) NSDEDDLAPGLKRPVNGTDDKFSGKEPKPSS
4) PSVGSTMDQDYNQTYTPQTHTPFMSNSAPPSNSGTGILPSPATPRFSAPTPRTPRTPRTPRGPASVQGSLK
5) RVSSTPGQAQTTGQLSQPPSKHKTGEGKADKVDKQQKRPHTPFHHRSLTSDDSSIETETTAGQNLTMRAQDGARFTGIRSSDMSSIQKAPQLHTGVVNTGPSEQTNSPQPPPLSPHPSERNDESGEVTKNLSSPNSQHFYQPPPEPCLVGVKTVGSSEEHGGSDSLNQHFQSHHLNPGISSFSEPPEPTIYVGTGLN
6) SSLLSQPFPSPTQSSSTQTSSSTSSQQGPGNTGGSSISSSSISGSVNGSTSSSSLMTSAGQPSSGMPSSKPTSFPPFGSMSTQAQGGAPQSGQLGQQASAHNTGSSGESSSSHALGPTEPPESTLEREKIGIPTDGE
2001
734
796
969
435
1478
2040
776
826
1039
631
1614










Molecular Recognition Features






MoRF SequenceStartStop




NANANA