<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP29023

Description Mediator complex subunit 25
SequenceMVAASALMEASNKPGNNQVADVVFVIEGTANLGPYFESLRKNYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLAVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDRGIHFSVVAPRKLPALRALYERASSVGGAVESHPDYSQDPFHMVLVRGISLPVSSGGGPGPIKPVVPPQPLPSQPPPPINAAHPYQNAPPMTAAQVAAQMAVEAATIQKSRFPGMVGQGPQFPSQSAIPSPPVKINISTVTTGNQQIMPQPQIPPSQQQPVPPQAQPVPSQQPPPPPPPPPQQPVPTQPAVPPAQPNMPGVPGPQGQPQVANKIVAWTGVLEWQEKPKASSMDSNTKLTRSLPCQVHVNQGENLNTDQWPQKLIMQLIPQQLLTTLGHLFRNSRMVQFLFTNKDMESLKGLYRIMTNGFAGCVHFSHTTSPCEVRVLMLLYSSKKKIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRVAAQLGAAGAPMQPGQVAPNQNFLNRPPGPIPVSHGNVQQQPVVVGMPPVSQVSLMEEQQRQSSMMSMRAAVPTNQQQQAGAPPNQVAQSGQAPPQGSILRLSNPGANPQLRSLLLSQQQPQGGVAHMQGMMPHQGLGQQMVHPTPGVGAQMQGQWRQPLGGQILMSGQRGAVPQSGMPQVSSVMEDEILMDLI
Length740
PositionUnknown
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.05
Grand average of hydropathy-0.264
Instability index55.22
Isoelectric point8.48
Molecular weight79357.12
Publications
PubMed=21551351

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP29023
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.93|      23|      23|     333|     355|       1
---------------------------------------------------------------------------
  309-  346 (31.40/ 6.01)	SPPvkinistvttgnQQIMPqPqiPPSQQQPVP.PQAQP
  347-  368 (41.80/10.59)	VPS............QQPPP.P.pPPPPQQPVP...TQP
  370-  387 (31.73/ 6.15)	VPP............AQPNM.P........GVPgPQGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.20|      15|      15|     546|     560|       3
---------------------------------------------------------------------------
  244-  257 (25.19/ 6.66)	VVPPQPLPSQ.PPPP
  546-  560 (24.38/ 6.21)	RVAAQLGAAGAPMQP
  562-  576 (24.63/ 6.35)	QVAPNQNFLNRPPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.39|      20|     369|     211|     230|       5
---------------------------------------------------------------------------
  211-  230 (38.38/19.16)	SHPDYSQDP..FHMVLVRGISL
  580-  601 (33.01/15.46)	SHGNVQQQPvvVGMPPVSQVSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.29|      41|      77|     422|     466|       6
---------------------------------------------------------------------------
  422-  466 (63.38/52.21)	PCQVHVNQgeNLNTDQwpQKLIMQLIPQQ...LLTTLGHLFRNSRMVQ
  500-  543 (66.90/40.57)	PCEVRVLM..LLYSSK..KKIFMGLIPNDqsgFVNGIRQVITNHKQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.41|      18|      22|     695|     712|      10
---------------------------------------------------------------------------
  695-  712 (36.18/19.06)	GAQMQ.G..QWRQPLGGQILM
  717-  737 (23.24/ 9.63)	GAVPQsGmpQVSSVMEDEILM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP29023 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGPGPIKPVVPPQPLPSQPPPPINAAHPYQNAPPMTAAQVAAQMAVEAATIQKSRFPGMVGQGPQFPSQSAIPSPPVKINISTVTTGNQQIMPQPQIPPSQQQPVPPQAQPVPSQQPPPPPPPPPQQPVPTQPAVPPAQPNMPGVPGPQGQPQVAN
2) RVAAQLGAAGAPMQPGQVAPNQNFLNRPPGPIPVSHGNVQQQPVVVGMPPVSQVSLMEEQQRQSSMMSMRAAVPTNQQQQAGAPPNQVAQSGQAPPQGSILRLSNPGANPQLRSLLLSQQQPQGGVAHMQGMMPHQGLGQQMVHPTPGVGAQMQGQWRQPLGGQILMSGQRGAVPQSGMPQVS
236
546
391
728










Molecular Recognition Features






MoRF SequenceStartStop




NANANA