<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28966

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAKKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQVANNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLMGQPQQPGFFLQNQSLAPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQNMPQGYTMYGTQMPLQQTSQQQAGSVVVSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2144
PositionKinase
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pongo.
Aromaticity0.07
Grand average of hydropathy-0.433
Instability index58.47
Isoelectric point8.04
Molecular weight239980.77
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:Ensembl

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28966
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     308.60|      27|      27|    2044|    2070|       1
---------------------------------------------------------------------------
 1833- 1862 (25.82/ 7.31)	PggsrLDPAGS.F.VP......TNTKQ....AL....SNML..QRRSG
 1865- 1890 (31.83/10.83)	M....Q.P..P.S.LHA.....ITSQQ....QL....IQMKllQQQQQ
 1895- 1922 (32.63/11.29)	R....QAQTRPfQ.QGQ.....PGDQA....AL....FAAQ..ARPSP
 1925- 1951 (37.83/14.34)	P....QYPGLQ.Q.AQN.....MPQGY....TM....YGTQ..MPLQQ
 1964- 1993 (29.47/ 9.45)	P....SYNSRA...YPA.....AHSNPvlmeRL....RQIQ..QQPSG
 1995- 2021 (24.97/ 6.82)	V....QQQASP.YlQP......LTGSQ....RLnhqaLQ......QSP
 2044- 2070 (55.24/24.51)	P....QDPMRP.R.QPQ.....VRQQQ....RL....LQMQ..QPQQP
 2072- 2099 (45.68/18.92)	P....QQPPQP.Q.QSS.....QPQSQ....TL...gLQAM..QPQQP
 2103- 2133 (25.12/ 6.90)	R....QGLQQT.Q.QQQqtaalVRQLQ....KQ....LSSN..QPQQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     267.52|      88|     150|    1052|    1201|       2
---------------------------------------------------------------------------
 1052- 1153 (135.31/218.28)	LKALCCSSN..HVWGF..NDVLCTVDVS..DLSFHDsLATFIAILIARQcfslEDVVQH.VALPSLLaaaCGDAD..AEPG.ARMTCRLLLHLFrapqaCFlPQATGKPFPG
 1205- 1302 (132.21/81.27)	MRGLRCDGNadDIWTAsqNPKSCGKSISieTANLRE.YARYVLRTICQQ....EWVGEHcLKEPERL...CTDKEliLDPVlSNMQAQKLLQLI.....CY.PHGIKECTEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     299.43|      95|     251|     554|     712|       7
---------------------------------------------------------------------------
  558-  665 (145.36/213.91)	SSSLAGS...SLPV.FQNVLLRFldtQAPSLSDPNsECEKVeFVNLvllfCEFIRHDVFSHD...AYMCTLISRGDLSVTAStRPRSPVGenaDEHYSKDHDVKMEIFSP.MPGES
  867-  969 (154.07/86.06)	SSSLAGSyttGLCVcIVAVLRRY...HSCLILNPD.QTAQV.FEGL....CGVVKHVVNPSEcssPERCILAYLYDLYVSCS.HLRSKFG...DLFSSACSKVKQTIYNNvMPANS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28966 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QPGFFLQNQSLAPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAI
2) QQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQNMPQGYTMYGTQMPLQQTSQQQAGSVVVSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
3) RSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLMGQP
1821
1890
1720
1873
2144
1819










Molecular Recognition Features






MoRF SequenceStartStop




NANANA