<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28963

Description Mediator complex subunit 25
SequenceMAAFPAALNRPTRVRARRRRISAHSAVSAAAAVVVAGTARGMVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPATPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQSQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPDGARRSDAAEWGSPGPGRSPQSPPLPLGSPVRQRVTAFHVSITSGKTKERRRGPRVSRKVGASLFLCGSEEHAYVFNMQTNRVCVERIQPETPL
Length834
PositionUnknown
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pongo.
Aromaticity0.05
Grand average of hydropathy-0.288
Instability index60.28
Isoelectric point9.62
Molecular weight87654.35
Publications









Function






Annotated function


GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28963
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.03|      39|      40|     627|     666|       1
---------------------------------------------------------------------------
  627-  666 (75.91/23.86)	PPQPQPQGTVGASGAT.GQSQPQGTA...QPPPgAPQ.G.PPGAAS
  668-  706 (49.72/11.08)	PPPPGPILRPQNPGA.....NPQLRSlllNPPP..PQtGvPPPQAS
  737-  770 (37.40/ 6.26)	..HPPPDGARRSDAAEwGSPGPGRSP...QSPP.LPL.G.SP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     237.13|      59|      60|     265|     323|       3
---------------------------------------------------------------------------
  185-  279 (73.60/19.46)	LICNSPP.YLLPAvestTYS.GCTTENLVQQ.IGERGIHFSIvsPRKLPALRllfekaappalleplqpptdvsqdprhmvlvRGLV...........................LPVGGGSAP.GP
  280-  342 (94.76/27.43)	LQSKQPV.PLPPA....TPS.GATLSAAPQQPLPPVPPQYQV..PGNLSAAQ............................vaaQNAV...........................EAAKNQKAGlGP
  343-  422 (68.78/17.64)	..RFSPItPLQQA....APGvGPPFSQAPAPQLPPGPPG..A..PKPPPASQ...................................pslvstvapgsglaptaqpgapsmagtVAPGGVSGP.SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.87|      21|      26|      27|      51|       4
---------------------------------------------------------------------------
   27-   48 (31.29/30.15)	VSAAAAVVVAGTArGMVPGSEG
   55-   75 (37.58/20.00)	VVADVVFVIEGTA.NLGPYFEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|      25|     505|     528|       5
---------------------------------------------------------------------------
  505-  528 (34.11/29.71)	LFrnSRMVQF.HFTNKDLESLKGLY
  534-  556 (37.50/25.23)	GF..AGCVHFpHTAPCEVRVLMLLY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28963 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSAPGPLQSKQPVPLPPATPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQQRGMGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQSQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPDGARRSDAAEWGSPGPGRSPQSPPLPLGSPVRQRVTAFHVSITSGKTKERRRGPRVSRKVGA
274
585
431
802










Molecular Recognition Features






MoRF SequenceStartStop




NANANA