<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28961
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRRIHILDTEHPWDLHSIPSEHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVKDPIVALSLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASETQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVLSMLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPNMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQAPGQPKIDHLRRLHLGACPTGECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCGPDACVTNRAAEEAPAFVQLSPRSTYRPPRTPRSLDRAHPEDHP |
Length | 725 |
Position | Tail |
Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae>
Pongo.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.037 |
Instability index | 48.65 |
Isoelectric point | 8.40 |
Molecular weight | 80360.27 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | |
GO - Biological Process | |
Interaction
Repeat regions
Repeats |
>MDP28961
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 108.03| 36| 363| 292| 348| 1
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96- 131 (64.10/31.02) LL..SADADGQIKCWSM.ADHL.ANSWESSVGSLV..KDPIV
293- 334 (43.92/61.54) LLcaSSQTSSIVECWSLrKEGLpVNNIFQQISPVVgdKQPTI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 102.24| 27| 132| 22| 48| 2
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22- 48 (53.17/31.98) EKWSKSTHCPSVPLACAWSCRNLIAFT
155- 181 (49.06/28.94) EKFSRVKFSPSLTLFGGKPMEGWIAVT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.39| 14| 318| 194| 207| 6
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194- 207 (24.38/15.74) SGQVLTSTESLCRL
514- 527 (24.01/15.39) STRILAMKASLCKL
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