<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28959

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKDLFFLPFTMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCLELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVDNFMLDYLPYLKTAYCKTLMFYLNLRSHSAAFVMLTLFSSLFCRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGSLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1586
PositionMiddle
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pongo.
Aromaticity0.05
Grand average of hydropathy-0.664
Instability index53.99
Isoelectric point8.97
Molecular weight169636.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
embryonic placenta development	GO:0001892	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lactation	GO:0007595	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
mammary gland branching involved in pregnancy	GO:0060745	IEA:Ensembl
mammary gland branching involved in thelarche	GO:0060744	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28959
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     941.68|     108|     110|    1040|    1147|       1
---------------------------------------------------------------------------
  616-  724 (104.40/21.09)	GNG..........GS.............TIGSSP.TP....PHHTPPPVSSMAGNTKNHPMLMNllKDNPAQDF.......StlyGSSPLerqnSSSGS.P........RMEICSGSNK.TKKKKSSRLPP.EK....PKHQTEDDF.QRELFS.....MD.................VDSQ...
  743-  857 (95.07/18.60)	................T.........PAPS.QCS.TP....PTTYPQPVPHPQPSIQR...MVR..LSSSDSIG.......P...DVTDI....LSDIAE.........EASKLPSTSD.DCPAIGTPLRD.SS....SSGHSQSTLfDSDVFQ.....TNnnenpytdpadliadaaGSPSSDS
  864-  988 (63.46/10.14)	HDGvdfnpdllnsQSQSgfgeeyfdeSSQSGDND.DF....KGFASQALN..TLGVP....MLG..GDNGETKFkgnnqadT...VDFSI....ISVAGKAlapadlmeHHSGSQGSLL.TTGDL.GKEKT.QKrvkeGNGTSNSTL.S....................................
  989- 1039 (48.11/ 6.04)	...............................................................G...P...................GLD....SKPGKRS........R...TPSNDG.KSKDKPPKRKK.AD....TEGKSPSH......SS.....SN.................RPFTPPT
 1040- 1147 (179.87/41.28)	STG..........GSKS.........PGSSGRSQ.TP....PGVATPPIPKITIQIPKGTVMVG..KPSSHSQY.......T...SSGSV....SSSGSKS........HHSHSSSSSS.SSASTSGKMKS.SK....SEGSSSSKL.SSSMYS.....SQ.................GSSGSSQ
 1148- 1201 (63.06/10.04)	SKN..........SSQS.........GGKPGSSPiTK....HG............................................................................lSSGSSSTKM....K....PQGKPSSLM.NPSLSK.....PN.................ISPSHS.
 1202- 1288 (108.30/22.13)	...............RP.........PGGSDKLA.SPmkpvPG..TPPSSK.....AKSPISSG..SGGSH..............MSGTS....SSSGMK.............SSSGLG.SSGSLSQK.....T....PPSSNSCTA.SSSSFS.....SS.................GSSMSSS
 1290- 1381 (112.10/23.15)	NQH..........GSSK.........GKSPSRNK.KP....S..LTAVIDKL....KHGVVTSG...PGGEDPL............DGQM....GVSTNSS........SHPMSSKHNM.SGGEFQGKREK.SD....KD...KSKV.STS.........G.................SSVDSSK
 1384- 1476 (103.11/20.75)	SE............SKN.........VGSTG.................VAKIIISKHDG....G..SPSIKAKV.......T...LQKPG....ESSGEGL........RPQMASSKNY.GSPLISG..ST.PK....HERGSPSHS.KSPAYTpqnldSE.................SESGSSI
 1487- 1553 (64.22/10.34)	SDD..........G...............................IRPLPEYSTEKHKKHKKEK..KKVKDKDR.......D...RDRDK....DRDKKKS........H...............SIKPESwSK....SPISSDQSL...SMTS...............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     424.32|     111|     113|     166|     278|       2
---------------------------------------------------------------------------
   62-  164 (86.30/46.28)	.............LETLQK.ALKDLFFLPFTMTDR..LESIArQNGLGSHLSASGTecYITSDMFYVevqlDP.AgQLCD....VKVAH....HgENPVS.CLELvqqlreknfdEFSKHLKGLVNLYN..........
  166-  278 (181.10/114.43)	PGDNKLkTKMYLALQSLEQ.DLSKMAIMYWKATNAGPLDKIL.HGSVGYLTPRSGG..HLMNLKYYV....SP.S.DLLD....DKTASPIILH.ENNVSrSLGM..........NASVTIEGTSAMYKLPI.APLIMG
  281-  387 (156.93/91.33)	PVDNKW.TPSFSSITSANSvDLP..ACFFLKFPQPIPVSRAF....VQKLQNCTGI..PLFETQPTY....APlY.ELITqfelSKDPDPIPLN.HN.......M..........RFYAALPGQQHCYFLNKdAPLPDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.33|      20|     117|     410|     448|       3
---------------------------------------------------------------------------
  410-  429 (36.27/51.50)	LNLIRHQVAYN..TLIGSCVKR
  483-  504 (31.07/ 8.17)	LNLRSHSAAFVmlTLFSSLFCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.70|      17|      21|     545|     562|       5
---------------------------------------------------------------------------
  545-  562 (30.24/19.24)	PPASSPGYGMTTGSNpMS
  567-  583 (34.46/17.14)	PTNTFPGGPITTLFN.MS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28959 with Med1 domain of Kingdom Metazoa
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