<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28958

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCLELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGSLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1540
PositionMiddle
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pongo.
Aromaticity0.04
Grand average of hydropathy-0.701
Instability index54.57
Isoelectric point8.99
Molecular weight163992.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28958
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     529.27|      63|      64|    1119|    1181|       2
---------------------------------------------------------------------------
  937-  990 (72.26/19.00)	S.N....STLSGPGLD......S.KPG..KRS.RTP..SNDGK.S.KDK............P....PKRKKAD.................................T.EG..KS.PSHSSSN..R.....PF.......T
  991- 1095 (50.58/10.82)	P.P....TS...TGGS......K.SPGSSGRSqTPPG.VATP....PI.PKitiqipKG..TvmvgKPSSHSQytssgsvsssgskshhshssssssssastsgkmK.SS..KS.EGSSSSKL.SssmysSQ.......G
 1096- 1135 (43.92/ 8.30)	S.SgssqSKNSSQSGG......K.PGSSP...........................................................................itK.HG..LS.SGSSSTKM.K.....PQ.......G
 1136- 1197 (98.72/28.99)	K.P....SSLMNPSLS......K.PNISPSHS.RPPG.GSDKLAS.PMKPV......PG..T....PPSSKAK.....................................spIS.SGSGGSHM.S.....GT.......S
 1198- 1251 (64.19/15.96)	S.S....SGMKSSSGL......G.SSGSLSQK.TPPS.SNSCTAS.......................SSSFS.................................S.SG..SS.MSSSQNQHgS.....SK.......G
 1252- 1318 (55.51/12.68)	KsP....SRNKKPSLTavidklK.HGVVTS....GPG.GEDPLDG.QM..........GvsT....NSSSHPM...............................ssK.HN..MS.GGEFQGKR.E.....KS.......D
 1319- 1391 (55.50/12.68)	K.D....KSKVSTSGS......S.VDSSKKTS.ESKNvGSTGVAKiIISKH......DG..G....SPSIKAK.............................vtlqK.PG..ES.SGEG...L.R.....PQmassknyG
 1392- 1437 (48.89/10.18)	S.P......LISGSTP......KhERGSPSHS.........K..S.PAY............T....PQN......................................lDS..ESeSGSSIAEK.S.....YQ.......N
 1438- 1482 (39.70/ 6.71)	S.P....SS..............................DDGI.R.PL.PE......YS..T....EKHKKHK............................kekkkV.KD..KD.RDRDRDKD.R.....DK.......K
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     476.37|      74|      76|     713|     786|       3
---------------------------------------------------------------------------
  457-  527 (91.97/33.18)	PVCMSIPVTMRAIR.RKAE...TI..QAD.T.....PALSL.IAETVEdmvkkNLPP......ASS..PGYGMTT.GS.NPMSGTTTP.T........NTFPG
  529-  581 (44.12/12.27)	PI....TTLFNM.SMSIKDrheSVghGEDFSkvsqnPILTS.LLQ....................................ITGNGGS.TIGS....S...PT
  582-  632 (59.16/18.84)	PPHHTPPPVSSM...AGNT...KN..HPMLM.....NLLKDnPAQDFS.....TLYG......SS........PLeRQ.NSSSG...................
  633-  693 (61.03/19.66)	...SP.....RMEICSGSN...KT..KK................KKSS.....RLPPekpkhqTEDD...FQREL....FSMDVDSQN.PIFDvnmtADTLDT
  713-  786 (126.22/48.14)	PVPHPQPSIQRMVRLSSSD...SI..GPDVT.....DILSD.IAEEAS.....KLPS......TSDDCPAIGTPL.RD.SSSSGHSQS.TLFD....SDVFQT
  792-  863 (93.87/34.01)	PYTDPADLIADAAGSPSSD...S....P.TN.....HFFHD.GVDFNP.....DLLN.......SQSQSGFGEEY.FDeSSQSGDNDDfKGFA....SQALNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      82.76|      19|      47|     306|     324|       4
---------------------------------------------------------------------------
  306-  321 (22.36/11.48)	..........KFPQPIPVSRA..FVQ.KL
  322-  348 (20.53/ 9.79)	QNCtgiplfeTQPTYAPLYEL..ITQfEL
  350-  367 (18.40/ 7.81)	..........KDPDPIPLNHNmrFYA.AL
  371-  388 (21.47/10.65)	QHC....yflNKDAPLPDGRS.......L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.04|      31|      47|     216|     247|       5
---------------------------------------------------------------------------
  216-  247 (51.77/32.12)	GGHLMnLKYYVSP....SDLLDDK.TAS.PIILHENNV
  261-  297 (41.27/20.50)	GTSAM.YKLPIAPlimgSHPVDNKwTPSfSSITSANSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28958 with Med1 domain of Kingdom Metazoa
Unable to open file!