<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28944

Description Mediator complex subunit 23
SequenceMESQLQSIFEDVVLAFSGFRMFMDTPEDERTKLISCLGAFRQYWGTLPQDSHEQCVQWIVRFIHTQRSPKRISFLYDCLAMAVETSLLPPRMVCVALISSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKGVLDKIQTVPITVSSAILQQLLAAREVVEYILDRNACLLPAYFAVTEIRKLYPEGQLSHWILGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLRGMLPYDKDLFEPQTVLLRYVLEQPYSREMVCNMLGLNKQQKQRCPVLEEQLVDLVVYAMERSETEEHFDADVGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHSFAMTCIWIHLNRKAQSDNSKLQIPIPHSLKLHHEFLQQSLRNKTLGMSDYKIALLCNAYSTNSECFTLPMGVLVETIYGNASVRTSLPGTNCMASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIHGTWCKDILHTIMSFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMAIENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQSDWHSKHMNYHKKYPEKLYFEGLADQVNPPIQQQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWGLSETYMKCGMNAREDNVWIPDDTYYCKLIGRKTPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRESITAWMNAIGLVITALPEPYWVVLHDRIVSVISSPALTSETDWVGYPFALLDFTACHQSYSEMNCSYVLALAHAVWHHSSIGQLSLTPKFLSEVLKPIVQTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQNCQHLSYMDPICDFLYHIKYMYTGDSVKEQVEKIIMTLRPAMKLRLRFITHSSLIETSSSAAAMAASTSSSSSSCGNPQPTPSLSSSNTAASPSTPSQHSHTPM
Length1378
PositionTail
OrganismOryzias latipes (Japanese rice fish) (Japanese killifish)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias.
Aromaticity0.10
Grand average of hydropathy-0.025
Instability index46.68
Isoelectric point7.45
Molecular weight157055.26
Publications
PubMed=17554307

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28944
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      35|     337|     346|       1
---------------------------------------------------------------------------
  337-  346 (18.69/12.01)	IFFVLFQFAS
  370-  379 (19.45/12.86)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     631.31|     163|     785|     382|     553|       2
---------------------------------------------------------------------------
  385-  553 (268.36/170.12)	NALA...DFL..PvmklFDLL........YPEKECIPVPDINKPQSTHSFAMTCIWIHLNRKAQSDNSKlqIPIPHS....L...KLHH...EFLQQSLRNKTLG...MSDYKIALLCN..AYSTNSECFTLP.MGVLVE.TIYGNASVRTSLPGTNCMASGSVTPLPMNLLDSLTVHA....KMSLIHS..IATRVIKLAHAKS
 1033- 1164 (148.57/80.54)	..........................................KDNRTPGWGLSETYMKCGMNAREDN....VWIPDD....TyycKL...........IGRKTPGpfpNCDWRFNEFPNpaAHALHVTCVEL..MALAVPgKDVGNALLNVVLKSQPLVPRESITAW.MNAI.GLVITAlpepYWVVLHD..RIVSVIS......
 1166- 1341 (214.37/118.85)	PALTsetDWVgyP....FALLdftachqsYSEMNCSYVLALAHAVWHHS...SIGQLSLTPKFLSEVLK...PIVQTefqlL...YVYHlvgPFLQRFQQERTRC...MLEIGVAFYEM..LQAVDQNCQHLSyMDPICD.FLY...HIKYMYTGDS..VKEQVEKIIMTLRPAMKLRL....RF.ITHSslIETSSSAAAMAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.90|      53|     786|     148|     210|       3
---------------------------------------------------------------------------
  148-  210 (71.15/66.93)	VSSAILQQllaAREVVEYIldRNACL..LPAY.FAVTEIRKLYP.....EGQLSHwiLGSLISdFVDsfRP
  939-  999 (85.74/48.26)	VNPPIQQQ...PQYLPIYF..GNVCLrfLPVFdIVIHRFLELLPvskslETLLDH..LGGLYK.FHD..RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.31|      17|     615|     727|     750|       5
---------------------------------------------------------------------------
   31-   49 (26.72/ 9.86)	TKLISCLGA.....FRQywGTLPQ
  727-  748 (27.58/18.20)	SHTLSCFPAplqafFKQ..NNVPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.35|      15|     258|     556|     571|       7
---------------------------------------------------------------------------
  556-  571 (21.14/19.47)	ALApALVETYSRLLVY
  816-  830 (27.21/18.53)	ALV.AHVRTFADFLVY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28944 with Med23 domain of Kingdom Metazoa
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