<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28940

Description Cyclin-dependent kinase 19
SequenceMDYDFKTKLAAERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFTVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYTNSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPNKRITSELALQDPYFLEDPLPTTDVFAGCQIPYPKREFLNEDEPEEKTEKHQQTAGQTQTQNQQQTTAQQAPSQQSSAQTNGTTGGAGATGGGGLQHSQDQGPPNKKPRLGPSGASSGTGVLQSEYQHSSSRLGYQSNTQSSTQSQNTMGYSSSSQQSSQYPRY
Length484
PositionKinase
OrganismOryzias latipes (Japanese rice fish) (Japanese killifish)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias.
Aromaticity0.09
Grand average of hydropathy-0.704
Instability index49.19
Isoelectric point8.66
Molecular weight55014.60
Publications
PubMed=17554307

Function

Annotated function 
GO - Cellular Component
cytosol	GO:0005829	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28940
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.06|      30|      36|     135|     165|       1
---------------------------------------------------------------------------
  135-  165 (52.24/39.05)	ILD.GIHYLHaNWVLH..RDLKPANILVMGEGPE
  171-  203 (45.82/29.35)	IADmGFARLF.NSPLKplADLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.90|      12|      15|     453|     464|       2
---------------------------------------------------------------------------
  453-  464 (22.32/13.34)	LGYQSNTQSSTQ
  469-  480 (22.58/13.58)	MGYSSSSQQSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.35|      23|      23|     399|     421|       3
---------------------------------------------------------------------------
  367-  389 (35.75/20.94)	KTEKHQQTAGQTQTQNQ.....QQTTAQ
  399-  421 (40.63/24.79)	QTNGTTGGAGATGGGGL.....QHSQDQ
  425-  449 (21.96/10.06)	NKKPRLGPSGASSGTGVlqseyQHS...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28940 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKTEKHQQTAGQTQTQNQQQTTAQQAPSQQSSAQTNGTTGGAGATGGGGLQHSQDQGPPNKKPRLGPSGASSGTGVLQSEYQHSSSRLGYQSNTQSSTQSQNTMGYSSSSQQSSQYPRY
351
484










Molecular Recognition Features






MoRF SequenceStartStop




1) GPPNKKPRLGPS
2) QSSQYPRY
3) SRLGYQS
422
477
451
433
484
457