<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28939

Description Cyclin-dependent kinase 19
SequenceMDYDFKTKLAAERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFTVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYTNSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPNKRITSELALQDPYFLEDPLPTTDVFAGCQIPYPKREFLNEDEPEEKTEKVITQTQNQQQTTAQQAPSQQSSAQTNGTTGGAGATGGGGLQHSQDQGPPNKKPRLGPSGASSGTGVLQSEYQHSSSRLGYQSNTQSSTQSQNTMGYSSSSQQSSQYPRY
Length435
PositionKinase
OrganismOryzias latipes (Japanese rice fish) (Japanese killifish)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias.
Aromaticity0.09
Grand average of hydropathy-0.757
Instability index50.67
Isoelectric point8.54
Molecular weight49519.36
Publications
PubMed=17554307

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28939
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     231.89|      71|     151|      12|      85|       1
---------------------------------------------------------------------------
   12-   85 (113.45/75.10)	ERERVE.DLFEYeGCKVGR.GTYGHVYKAKRKDGKDEKEYALKQIEG..TGISMSACREIALLRelKHPNVIALQKVF
  165-  239 (118.43/69.35)	ERGRVKiDIWAI.GCIFAElLTSEPIFHCRQEDIKTSNPFHHDQLDRifTVMGFPADKDWEDIR..KMPEYPTLQKDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.90|      12|      15|     404|     415|       2
---------------------------------------------------------------------------
  404-  415 (22.32/11.87)	LGYQSNTQSSTQ
  420-  431 (22.58/12.08)	MGYSSSSQQSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.74|      24|      24|     346|     369|       6
---------------------------------------------------------------------------
  346-  369 (42.25/27.23)	QSSAQTNGTTGGAGATGGGGLQHS
  372-  395 (43.48/28.23)	QGPPNKKPRLGPSGASSGTGVLQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28939 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKTEKVITQTQNQQQTTAQQAPSQQSSAQTNGTTGGAGATGGGGLQHSQDQGPPNKKPRLGPSGASSGTGVLQSEYQHSSSRLGYQSNTQSSTQSQNTMGYSSSSQQSSQYPRY
307
435










Molecular Recognition Features






MoRF SequenceStartStop




1) PPNKKPRLGP
2) QSSQYPRY
3) SRLGYQS
4) VLQSEYQH
374
428
402
392
383
435
408
399