<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28933

Description Mediator complex subunit 14
SequenceMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLRQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLDILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLSVWNQQVLGKKTGTAPVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKTSNPSDNSFIETALPTLVVPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTINEDMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCTDVLHLSNSTSHPVGSLSKHKLFIKLTRLPQCYIVVEMLDVPCNPTALQYKYSFLSVSQLEGEDGLLCAQLLQHFKPNLEHLVQDAIVHKELRSGTKRKSSGDQCDTEPKKPKRSGEMCAFNKELAHLVAICDTNMPFVSLRTELSNMEIPSQGVQVEVDGSGHAIRLLKIPPCKGVGEETRRALERSLLDCTFRLQGRNNRTWVAELVLASCPLNSTNSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNAISQLYQCVLNFSCVLPEMPSYLNLFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSSSQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVLQLLQVLYDTLAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGGDMDSLINQLQAPQQPQSMRGAAGGVYPPLTSPPPNYHTNVTPSPSMMPTQSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGPLDPSSPYAMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPHSPRAGTSSQVMPTSMPPPRKLPQRPWAASIPTILTHSALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEANLTIVNSNEPGVIMFKTDVLKCRVALNPKNYQTLQLKVTPENTGPWSQEELQVLERFFETRVAGPPFKFNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRIPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPPRQGECTIFASVHDLMVNLTFPPGTR
Length1368
PositionTail
OrganismOryzias latipes (Japanese rice fish) (Japanese killifish)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias.
Aromaticity0.06
Grand average of hydropathy-0.178
Instability index51.62
Isoelectric point8.69
Molecular weight152023.12
Publications
PubMed=17554307

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28933
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     114.92|      22|      29|     972|     993|       1
---------------------------------------------------------------------------
  960-  982 (25.71/ 7.97)	..PTQSPGNIhasG.........SPSGALRAP..SP
  983- 1013 (34.04/13.26)	FGPTPSPSSL...GiamgqtsfaSPHGPLDPS..SP
 1014- 1031 (29.43/10.33)	YAMV.SPSHR...G.........QWPG...SP..QV
 1032- 1057 (25.75/ 8.00)	SGPSPGARIP...G.......msPGNPSLHSPipDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     345.20|     111|     230|     451|     680|       2
---------------------------------------------------------------------------
  333-  452 (176.44/176.82)	QKLQELKAILKTSNPSDNsfIETALPTLVVP....ILEPCGRSECLHIF.VDLHSGMFQPMLYGLDQSMLDDIEKTINEDMKriiSWLQQLKFwlgeQRC.RQSVKHLPTVCTDVLHLS..NSTSHPV
  561-  679 (168.76/184.78)	KELAHLVAICDTNMPFVS..LRTELSNMEIPsqgvQVEVDGSGHAIRLLkIPPCKGVGEETRRALERSLLDCTFRLQGRNNR...TWVAELVL....ASCpLNSTNSKEQASTRHVYLTyeNPLSEPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.65|      19|      52|     691|     711|       3
---------------------------------------------------------------------------
  691-  711 (31.59/25.05)	DWNAISQLYQcvLNFSCVLPE
  745-  763 (36.06/21.12)	QWNSSSQRFH..LALGTVGPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.11|      19|     128|     928|     946|       4
---------------------------------------------------------------------------
  908-  942 (27.66/11.36)	S.PvggdmdslinqlqapqQP..QSMRGAAGGVYPPLT
 1072- 1093 (27.45/11.21)	SmP................PPrkLPQRPWAASIPTILT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.25|      67|     386|     826|     906|       8
---------------------------------------------------------------------------
  826-  906 (96.47/92.73)	FSILPQSPTHIrlaFRNmyCIDIYcrsrGVVAIRDGAYSLFDNTKIVEGFYPA......PG.....LKTFLNMFVdsnQDARRRSVNEDdnP
 1218- 1295 (110.78/66.51)	FTKLLGAPTNI...LRD..CVRIM....KLELFPDQAAQLKWNVQFCLTIPPSappiapPGtiavvLKSKMLFFL...QLTQRIPVPQD..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.77|      23|    1016|     153|     175|      13
---------------------------------------------------------------------------
  153-  175 (40.04/24.51)	EATLTVM.GDDPDIPWRLLKLDIL
 1142- 1163 (29.13/15.69)	EANLTIVnSNEPGVI..MFKTDVL
 1176- 1197 (35.60/20.92)	TLQLKVT.PENTG.PWSQEELQVL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28933 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPVGGDMDSLINQLQAPQQPQSMRGAAGGVYPPLTSPPPNYHTNVTPSPSMMPTQSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGPLDPSSPYAMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPHSPRAGTSSQVMPTSMPPPRKLPQRPWA
892
1085










Molecular Recognition Features






MoRF SequenceStartStop




NANANA